Bo Liu, Shuang Song, Inmaculada Ruz Maldonado, Attilio Pingitore, Guo C Huang, David Baker, Peter M Jones, Shanta J Persaud
AIMS: The novel cannabinoid receptor GPR55 is expressed by rodent islets and it has been implicated in β-cell function in response to a range of ligands. This study evaluated the effects of GPR55 ligands on intracellular calcium ([Ca(2+) ]i ) levels and insulin secretion from islets isolated from GPR55 knockout (GPR55(-/-) ) mice, age-matched wildtype (WT) mice, and human pancreas. MATERIALS AND METHODS: GPR55 expression was determined by western blotting and fluorescent immunohistochemistry...

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