Atheer Zgair, Jonathan Cm Wong, Jong Bong Lee, Jatin Mistry, Olena Sivak, Kishor M Wasan, Ivo M Hennig, David A Barrett, Cris S Constantinescu, Peter M Fischer, Pavel Gershkovich
There has been an escalating interest in the medicinal use of Cannabis sativa in recent years. Cannabis is often administered orally with fat-containing foods, or in lipid-based pharmaceutical preparations. However, the impact of lipids on the exposure of patients to cannabis components has not been explored. Therefore, the aim of this study is to elucidate the effect of oral co-administration of lipids on the exposure to two main active cannabinoids, Δ(9)-tetrahydrocannabinol (THC) and cannabidiol (CBD). In this study, oral co-administration of lipids enhanced the systemic exposure of rats to THC and CBD by 2... Click Below for More