from NIH PubMed

Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.

Extensive research within the past two decades has revealed that obesity, a major risk factor for type 2 diabetes, atherosclerosis, cancer, and other chronic diseases, is a proinflammatory disease. Several spices have been shown to exhibit activity against obesity through antioxidant and anti-inflammatory mechanisms. Among them, curcumin, a yellow pigment derived from the spice turmeric (an essential component of curry powder), has been investigated most extensively as a treatment for obesity and obesity-related metabolic diseases. Curcumin directly interacts with adipocytes, pancreatic cells, hepatic stellate cells, macrophages, and muscle cells. There, it suppresses the proinflammatory transcription factors nuclear factor-kappa B, signal transducer and activators of transcription-3, and Wnt/beta-catenin, and it activates peroxisome proliferator-activated receptor-gamma and Nrf2 cell-signaling pathways, thus leading to the downregulation of adipokines, including tumor necrosis factor, interleukin-6, resistin, leptin, and monocyte chemotactic protein-1, and the upregulation of adiponectin and other gene products. These curcumin-induced alterations reverse insulin resistance, hyperglycemia, hyperlipidemia, and other symptoms linked to obesity.

from NIH PubChem

Therapeutic Uses

EXPL THER Curcumin (Cum) has been reported to have potential chemo-preventive and chemotherapeutic activity through influencing various processes, inducing cell cycle arrest, differentiation and apoptosis in a series of cancers. However, the poor solubility of Cum limits its further applications in the treatment of cancer. /The authors/ have previously reported Cum-loaded nanoparticles (Cum-NPs) prepared with amphilic methoxy poly(ethylene glycol)-polycaprolactone (mPEG-PCL) block copolymers. The current study demonstrated superior antitumor efficacy of Cum-NPs over free Cum in the treatment of lung cancer. In vivo evaluation further demonstrated superior anticancer effects of Cum-NPs by delaying tumor growth compared to free Cum in an established A549 transplanted mice model. Moreover, Cum-NPs showed little toxicity to normal tissues including bone marrow, liver and kidney at a therapeutic dose. These results suggest that Cum-NPs are effective to inhibit the growth of human lung cancer with little toxicity to normal tissues, and could provide a clinically useful therapeutic regimen. They thus merit more research to evaluate the feasibility of clinical application./ Curcumin-loaded nanoparticles/ Abstract:PubMed

Yin HT et al; Asian Pac J Cancer Prev 14 (1): 409-12 (2013)

EXPL THER Accumulation of amyloid peptide (Abeta) in senile plaques is a hallmark lesion of Alzheimer disease (AD). The design of molecules able to target the amyloid pathology in tissue is receiving increasing attention, both for diagnostic and for therapeutic purposes. Curcumin is a fluorescent molecule with high affinity for the Abeta peptide but its low solubility limits its clinical use. Curcumin-conjugated nanoliposomes, with curcumin exposed at the surface, were designed. They appeared to be monodisperse and stable. They were non-toxic in vitro, down-regulated the secretion of amyloid peptide and partially prevented Abeta -induced toxicity. They strongly labeled Abeta deposits in post-mortem brain tissue of AD patients and APPxPS1 mice. Injection in the hippocampus and in the neocortex of these mice showed that curcumin-conjugated nanoliposomes were able to specifically stain the Abeta deposits in vivo.Curcumin-conjugated nanoliposomes could find application in the diagnosis and targeted drug delivery in AD. In this preclinical study, curcumin-conjugated nanoliposomes were investigated as possible diagnostics and targeted drug delivery system in Alzheimer's disease, demonstrating strong labeling of Abeta deposits both in human tissue and in mice, and in vitro downregulation of amyloid peptide secretion and prevention of Abeta -induced toxicity./ Curcumin-conjugated nanoliposomes/ Abstract: PubMed

Lazar AN et al; Nanomedicine 9 (5): 712-21 (2013)
EXPL THER The anti-inflammatory agent curcumin can selectively eliminate malignant rather than normal cells. The present study examined the effects ofcurcumin on the Lewis lung carcinoma (LLC) cell line and characterized a subpopulation surviving curcumin treatments. Cell density was measured aftercurcumin was applied at concentrations between 10 and 60 uM for 30 hours. Because of the high cell loss at 60 uM, this dose was chosen to select for surviving cells that were then used to establish a new cell line. The resulting line had approximately 20% slower growth than the original LLC cell line and based on ELISA contained less of two markers, NF-kB and ALDH1A, used to identify more aggressive cancer cells. /The authors/ also injected cells from the original and surviving lines subcutaneously into syngeneic C57BL/6 mice and monitored tumor development over three weeks and found that the curcuminsurviving-line remained tumorigenic. Because curcumin has been reported to kill cancer cells more effectively when administered with light, /the authors/ examined this as a possible way of enhancing the efficacy of curcumin against LLC cells. When LLC cells were exposed to curcumin and light from a fluorescent lamp source, cell loss caused by 20 uM curcumin was enhanced by about 50%, supporting a therapeutic use of curcumin in combination with white light. This study is the first to characterize a curcumin-surviving subpopulation among lung cancer cells. It shows that curcumin at a high concentration either selects for an intrinsically less aggressive cell subpopulation or generates these cells. The findings further support a role for curcumin as an adjunct to traditional chemical or radiation therapy of lung and other cancers.[Yan D et al; J Cancer 3: 32-41 (2012)] Full text: PMC3253430 Abstract: PubMed
EXPL THER 5-Fluorouracil (5-FU) is the first rationally designed antimetabolite, which achieves its therapeutic efficacy through inhibition of the enzymethymidylate synthase (TS), which is essential for the synthesis and repair of DNA. However, prolonged exposure to 5-FU induces TS overexpression, which leads to 5-FU resistance in cancer cells. Several studies have identified curcumin as a potent chemosensitizer against chemoresistance induced by various chemotherapeutic drugs. In this study, /investigators/ report for the first time, with mechanism-based evidences, that curcumin can effectively chemosensitize breast cancer cells to 5-FU, thereby reducing the toxicity and drug resistance. /The authors/ found that 10 uM 5-FU and 10 uM curcumin induces a synergistic cytotoxic effect in different breast cancer cells, independent of their receptor status, through the enhancement of apoptosis. Curcumin was found to sensitize the breast cancer cells to 5-FU through TS-dependent downregulation of nuclear factor-kB (NF-kB), and this observation was confirmed by silencing TS and inactivating NF-kB, both of which reduced the chemosensitizing efficacy of curcumin. Silencing of TS suppressed 5-FU-induced NF-kB activation, whereas inactivation of NF-kB did not affect 5-FU-induced TS upregulation, confirming that TS is upstream of NF-kB and regulates the activation of NF-kB in 5-FU-induced signaling pathway. Although Akt/PI3kinase and mitogen-activated protein kinase pathways are activated by 5-FU and downregulated by curcumin, they do not have any role in regulating the synergism. As curcumin is a pharmacologically safe and cost-effective compound, its use in combination with 5-FUmay improve the therapeutic index of 5-FU, if corroborated by in vivo studies and clinical trials.[Vinod BS et al; Cell Death Dis 4: e505 (2013)] Full text:PMC3734809 Abstract: PubMed

EXPL THER This study was carried out to evaluate the anti parasitic potential of silver, chitosan, and curcumin nanoparticles as anti-Giardia agents. Non-treated infected control rats were inoculated with Giardia lamblia cysts in a dose of 2x10+5 cysts/rat. Experimental group was infected then treated withcurcumin, curcumin nanoparticles, chitosan, chitosan nanoparticles, and silver nanoparticles as single or combined therapy. The number of Giardia cysts in stools and trophozoites in intestinal sections were detected. Toxicity of nanoparticles was evaluated by comparing hematological and histopathological parameters of the normal control group and treated non-infected control group. The amount of silver was also measured in the liver, kidney, small intestine, lung, and brain of rats treated with silver nanoparticles. The number of the parasites in stool and small intestinal sections decreased in treated infected rats compared with infected non-treated ones. The effect in the single therapy was better with nanoparticles, and the best effect was detected in nano-silver. The combined therapy gave better results than single. Combination between nanoparticles was better than the combination of nano-forms and native chitosan andcurcumin. The best effect was detected in combinations of nano-silver and nano-chitosan but with no full eradication. In conclusion, the highest effect and complete cure was gained by combining the three nano-forms. The parasite was successfully eradicated from stool and intestine. None of the treatments exhibited any toxicity. Accumulated silver in different organs was within the safe limits./ Curcumin nanoparticles/ Abstract: PubMed

Said DE et al; Parasitol Res 111 (2): 545-54 (2012)
EXPL THER Radiation pneumonitis (RP) is an important dose-limiting toxicity during thoracic radiotherapy. Previous investigations have shown that curcumin is used for the treatment of inflammatory conditions and cancer, suggesting that curcumin may prevent RP and sensitize cancer cells to irradiation. However, the clinical advancement of curcumin is limited by its poor water solubility and low bioavailability after oral administration. Here, a water-soluble liposomalcurcumin system was developed to investigate its prevention and sensitizing effects by an intravenous administration manner in mice models. The results showed that liposomal curcumin inhibited nuclear factor-kappaB pathway and downregulated inflammatory factors including tumor necrosis factor-alpha, interleukin (IL)-6, IL-8, and transforming growth factor-beta induced by thoracic irradiation. Furthermore, the combined treatment with liposomal curcumin and radiotherapy increased intratumoral apoptosis and microvessel responses to irradiation in vivo. The significantly enhanced inhibition of tumor growth also was observed in a murine lung carcinoma (LL/2) model. There were no obvious toxicities observed in mice. The current results indicate that liposomal curcumin can effectively mitigate RP, reduce the fibrosis of lung, and sensitize LL/2 cells to irradiation. This study also suggests that the systemic administration of liposomalcurcumin is safe and deserves to be investigated for further clinical application./Liposomal curcumin/[Shi HS et al; Int J Nanomedicine 7: 2601-11 (2012)] Full text: PMC3368513 Abstract: PubMed

EXPL THER The up regulation of gut mucosal cytokines such as tumor necrosis factor (TNF)-alpha and oxidative stress have been related to inflammatory bowel diseases (IBD) such as ulcerative colitis (UC) and Crohn's disease (CD). This study investigated an immune-mediated model of colitis. TNF-alpha injected intraperitonally to mice induced a dose-dependent recruitment of neutrophils into abdominal mesentery. The leukocytes influx induced by TNF-alpha (10 ug/kg body weight) increased by 3 fold liver and colon damage scores. TNF-alpha-colitis was characterized by hemorrhagic edemas and crypt abscesses massively infiltrated by inflammatory cells, namely neutrophils. Moreover, TNF-alpha-toxicity resulted in liver steatosis and foci of necrosis infiltrated by Kupffer cells and neutrophils in parenchyma and around the centrilobular veins. The involvement of oxidative stress was evaluated using aminoguanidine (AG) as selective inhibitor of inducible NO synthase (iNOS) and curcumin (Cur), the polyphenolic antioxidant of turmeric (Curcuma longa L.). TNF-alpha-toxicity led to significant increase in myeloperoxidase (MPO, an index of neutrophils infiltration), nitrites (stable nitric oxide metabolites) and malondialdehyde (MDA, a marker of lipid peroxides) levels and cell apoptosis in liver and colon. AG and Cur treatments significantly attenuated the hallmarks of oxidative stress, neutrophils influx and ROS-related cellular and histological damages, in TNF-alpha-treated mice. Taken together, /these/ results provide insights into the role of phagocytes-derived oxidants in TNF-alpha-colitis in mice. Cur and AG, by inhibiting neutrophils priming and iNOsynthase could be effective against oxidative bowel damages induced in IBD by imbalanced gut immune response. Abstract: PubMed

Mouzaoui S et al; Int Immunopharmacol 12 (1): 302-11 (2012)

EXPL THER Photodynamic therapy is a technique that involves the activation of photosensitizers by light in the presence of tissue oxygen, resulting in the production of reactive radicals capable of inducing cell death. The present study assessed the overall susceptibility of pathogens of salivary flora to photodynamic therapy after sensitization with curcumin and exposure to blue light at 450 nm. A randomized trial was executed with 13 adult volunteers. Three different groups were analyzed: L-D- (no light, no drug; control group), L-D+ (treated only with the drug; curcumin group) and L+D+ (treated with drug and light; photodynamic therapy group). Non-stimulated saliva samples were collected for bacterial counts at baseline and after the experimental phase, and adverse events experienced were recorded. Serial dilutions were performed, and the resulting samples were cultured on blood agar plates in microaerophilic conditions. The number of colony-forming units was then determined. There was a considerable difference between the two experimental groups with regard to effectiveness of bacterial reduction. In the L-D+ group, the bacterial decline was considerably smaller (9%) than in the L+D+ group, with a 68% decrease in bacteria. A statistically significant reduction in the bacterial population was observed only in the photodynamic therapy group (p<0.05). Photodynamic therapy was found to be effective in the reduction of salivary microorganisms. No significant reduction was found for the group in which only curcumin was used, proving the absence of dark toxicity of the drug. This work shows that overall disinfection of the mouth can be done with a simple procedure involving photodynamic action. Abstract: PubMed

Araujo NC et al; Photomed Laser Surg 30 (2): 96-101 (2012)

EXPL THER Previous studies suggested that curcumin is a potential agent against glioblastomas (GBMs). However, the in vivo efficacy of curcumin in gliomas remains not established. In this work, /the authors/ examined the mechanisms underlying apoptosis, selectivity, efficacy and safety of curcumin from in vitro (U138MG, U87, U373 and C6 cell lines) and in vivo (C6 implants) models of GBM. In vitro, curcumin markedly inhibited proliferation and migration and induced cell death in liquid and soft agar models of GBM growth. Curcumin effects occurred irrespective of the p53 and PTEN mutational status of the cells. Interestingly, curcumin did not affect viability of primary astrocytes, suggesting that curcumin selectivity targeted transformed cells. In U138MG and C6 cells,curcumin decreased the constitutive activation of PI3K/Akt and NFkappaB survival pathways, down-regulated the antiapoptotic NFkappaB-regulated protein bcl-xl and induced mitochondrial dysfunction as a prelude to apoptosis. Cells developed an early G2/M cell cycle arrest followed by sub-G1 apoptosis and apoptotic bodies formation. Caspase-3 activation occurred in the p53-normal cell type C6, but not in the p53-mutant U138MG. Besides its apoptotic effect,curcumin also synergized with the chemotherapeutics cisplatin and doxorubicin to enhance GBM cells death. In C6-implanted rats, intraperitoneal curcumin(50 mg/kg/d) decreased brain tumors in 9/11 (81.8%) animals against 0/11 (0%) in the vehicle-treated group. Importantly, no evidence of tissue (transaminases,creatinine and alkaline phosphatase), metabolic (cholesterol and glucose), oxidative or hematological toxicity was observed. In summary, data presented here suggest curcumin as a potential agent for therapy of GBMs. Abstract: PubMed

Zanotto-Filho A et al; J Nutr Biochem 23 (6): 591-601 (2012)

EXPL THER Curcumin has been shown to have high cytotoxicity towards various cancer cell lines, but its water insolubility and instability make its bioavailability exceedingly low and, thus, it is generally inactive in in vivo anticancer tests. Here, we report an intracellular-labile amphiphilic surfactant-likecurcumin prodrug--curcumin conjugated with two short oligo(ethylene glycol) (Curc-OEG) chains via beta-thioester bonds that are labile in the presence of intracellular glutathione and esterase. Curc-OEG formed stable nanoparticles in aqueous conditions and served two roles--as an anticancer prodrug and a drug carrier. As an anticancer prodrug, the formed nanoparticles had a high and fixed curcumin-loading content of 25.3 wt%, and released active curcumin in the intracellular environment. Curc-OEG had high inhibition ability to several cancer cell lines due to apoptosis. Intravenously injected Curc-OEG significantly reduced the tumor weights and tumor numbers in the athymic mice xenografted with intraperitoneal SKOV-3 tumors and subcutaneous (mammary fat pad) MDA-MB-468 tumors. Preliminary systemic toxicity studies found that Curc-OEG did not cause acute and subchronic toxicities to mouse visceral organs at high doses. As drug carriers, Curc-OEG nanoparticles could carry other anticancer drugs, such as doxorubicin and camptothecin, and ship them into drug-resistant cells, greatly enhancing the cytotoxicity of the loaded drug. Thus, Curc-OEG is a promising prototype that merits further study for cancer therapy./ Molecular carrier system/ Abstract: PubMed

Tang H et al; Nanomedicine (Lond) 5 (6): 855-65 (2010)

EXPL THER This study aims at the formulation of curcumin with biodegradable thermoresponsive chitosan-g-poly (N-vinylcaprolactam) nanoparticles (TRC-NPs) for cancer drug delivery. The spherical curcumin-loaded nanoparticles of size 220 nm were characterized, and the biological properties were studied using flow cytometry and cytotoxicity by MTT assay. The in vitro drug release was higher at above LCST compared to that at below LCST. TRC-NPs in the concentration range of 100-1000 ug/mL were non-toxic to an array of cell lines. The cellular localization of the curcumin-loaded TRC-NPs was confirmed from green fluorescence inside the cells. The time-dependent curcumin uptake by the cells was quantified by UV spectrophotometer. Curcumin-loaded TRC-NPs showed specific toxicity to cancer cells at above their LCST. Flow cytometric analysis showed increased apoptosis on PC3 compared to L929 by curcumin-loaded TRC-NPs. These results indicate that novel curcumin-loaded TRC-NPs could be a promising candidate for cancer drug delivery. /Curcumin-loaded biocompatible thermoresponsive polymeric nanoparticles/ Abstract: PubMed

Rejinold NS et al; J Colloid Interface Sci 360 (1): 39-51 (2011)

EXPL THER Inflammatory bowel disease (IBD) is a major source of morbidity in children and adults. Its incidence is rising, particularly in young people. IBD carries a lifelong risk of cancer, which is proportional to disease duration. Drug and surgical treatments rarely offer cure and often carry a high side effect burden. Dietary therapy is highly effective in Crohn's disease. For these reasons, there is much interest in developing novel dietary treatments in IBD.Curcumin, a component of the spice turmeric, and an anti-inflammatory and anti-cancer agent, shows preclinical and clinical potential in IBD. Its mechanisms of action are unknown. /This study's/ aim was to assess the effect of curcumin on key disease mediators p38 mitogen-activated protein kinase (MAPK), IL-1beta, IL-10 and matrix metalloproteinase-3 (MMP-3) in the gut of children and adults with IBD. Colonic mucosal biopsies and colonic myofibroblasts (CMF) from children and adults with active IBD were cultured ex vivo with curcumin. p38 MAPK, NF-kappaB and MMP-3 were measured by immunoblotting. IL-1beta and IL-10 were measured by ELISA. /Investigators/ show reduced p38 MAPK activation in curcumin-treated mucosal biopsies, enhanced IL-10 and reduced IL-1beta. /They/ demonstrate dose-dependent suppression of MMP-3 in CMF with curcumin. /They/ conclude that curcumin, a naturally occurring food substance with no known human toxicity, holds promise as a novel therapy in IBD. Abstract: PubMed

Epstein J et al; Br J Nutr 103 (6): 824-32 (2010)

EXPL THER Curcumin (CCM), a yellow natural polyphenol extracted from turmeric (Curcuma longa), has potent anti-cancer properties as has been demonstrated in various human cancer cells. However, the widespread clinical application of this efficient agent in cancer and other diseases has been limited by its poor aqueous solubility and bioavailability. In this study, we prepared novel CCM-loaded human serum albumin (HSA) nanoparticles (CCM-HSA-NPs) for intravenous administration using albumin bound technology. Field emission scanning electron microscopy (FE-SEM) and dynamic light scattering (DLS) investigation confirmed a narrow size distribution in the 130-150nm range. Furthermore, CCM-HSA-NPs showed much greater water solubility (300-fold) than free CCM, and on storage, the biological activity of CCM-HSA-NPs was preserved with negligible activity loss. In vivo distributions and vascular endothelial cells transport studies demonstrated the superiority of CCM-HSA-NPs over CCM. Amounts of CCM in tumors after treatment with CCM-HSA-NPs were about 14 times higher at 1hr after injection than that achieved by CCM. Furthermore, vascular endothelial cell binding of CCM increased 5.5-fold, and transport of CCM across a vascular endothelial cell monolayer by Transwell testing was 7.7-fold greater for CCM-HSA-NPs than CCM. Finally, in vivo antitumor tests revealed that CCM-HSA-NPs (10 or 20mg/kg) had a greater therapeutic effect (50% or 66% tumor growth inhibition vs. PBS-treated controls) than CCM (18% inhibition vs. controls) in tumor xenograft HCT116 models without inducing toxicity. /Investigators/ attribute this potent antitumor activity of CCM-HSA-NPs to enhanced water solubility, increased accumulation in tumors, and an ability to traverse vascular endothelial cell. / curcumin-loaded human serum albumin (HSA) nanoparticles/ Abstract: PubMed

Kim TH et al; Int J Pharm 403 (1-2): 285-91 (2011)

EXPL THER In-stent restenosis is the major problem of percutaneous coronary interventions. Drug-eluting stent became a landmark in the treatment of coronary disease. Curcumin could be used for drug-eluting stent due to its antithrombogenity and antiproliferative properties. In this paper, 3-(4, 5-Dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide (MTT) assays were performed to decide the optimal concentration of curcumin for inhibiting the proliferation of vascular smooth muscle cells (VSMC). The result disclosed that more than 80% of VSMC were inhibited when the concentration of curcuminranged from 2.5 ug/mL to 10 ug/mL (P < 0.05, compared to ethanol). Three weight percent curcumin-loaded films (3wt%, 5wt%, 8wt%) were prepared using a biodegradable polymer (poly (lactic acid-co-glycol acid), PLGA) as the carrier of curcumin. The release of lactate dehydrogenase (LDH) was used to evaluate the immediate toxicity of the curcumin-loaded PLGA films, and the three concentration curcumin-loaded films were revealed to be of no acute toxicity to the smooth muscle cells. The results of Alamar Blue test indicated that the curcumin-loaded films had better antiproliferation effect than did the 316 stainless steel (SS). Therefore, these films may be used for stent coating to inhibit the in-stent restenosis induced by VSMC proliferation./ curcumin-loaded films/ Abstract:PubMed

Ren L et al; Sheng Wu Yi Xue Gong Cheng Xue Za Zhi 25 (4): 874-8 (2008)

EXPL THER The present work is aimed at evaluating the radioprotective effect of curcumin, a naturally occurring phenolic compound on gamma-radiation induced toxicity. The cellular changes were estimated by using lipid peroxidative indices like thiobarbituric acid reactive substances (TBARS), the antioxidantssuperoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH). The DNA damage was analyzed by using cytokinesis blocked micronucleus assay and dicentric aberration (DC). The gamma-radiation at different doses (1, 2 and 4Gy) were found to significantly increase micronuclei (MN), DC frequencies and TBARS level whereas the levels of GSH and antioxidant enzymes were significantly decreased. The maximum damage to lymphocytes was observed at 4Gy irradiation. Curcumin pretreatment (1, 5 and 10 ug/mL) significantly decreased the frequency of MN and DC. The levels of TBARS decreased and activities of SOD, CAT and GPx significantly increased along with GSH levels. At 1Gy irradiation all the concentrations ofcurcumin (1, 5 and 10 ug/mL) significantly protected the lymphocytes from radiation damage. At 2Gy irradiation, 5 and 10 ug/mL of curcumin showed significant radioprotection. Since the highest damage was observed at 4Gy irradiation both 1 and 5 ug/mL of curcumin pretreatment were not sufficient to protect the lymphocytes from radiation damage but 10 ug/mL of curcumin significantly protected the cultured lymphocytes from radiation damage. Thus, pretreatment with curcumin gives protection to lymphocytes against gamma-radiation induced cellular damage. Abstract: PubMed

Srinivasan M et al; Mutat Res 611 (1-2): 96-103 (2006)

EXPL THER In recent years, considerable interest has been focused on curcumin a compound, isolated from turmeric. Curcumin is used as a coloring, flavoring agent and has been traditionally used in medicine and cuisine in India. The varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. This chapter reviews the data on the use of curcumin for the chemoprevention and treatment of various skin diseases like scleroderma, psoriasis and skin cancer. Curcumin protects skin by quenching free radicals and reducing inflammation through nuclear factor-KB inhibition. Curcumin treatment also reduced wound-healing time, improved collagen deposition and increased fibroblast and vascular density in wounds thereby enhancing both normal and impaired wound-healing. Curcumin has also been shown to have beneficial effect as a proangiogenic agent in wound-healing by inducing transforming growth factor-beta, which induces both angiogenesis and accumulation of extracellular matrix, which continues through the remodeling phase of wound repair. These studies suggest the beneficial effects of curcumin and the potential of this compound to be developed as a potent nontoxic agent for treating skin diseases.Abstract: PubMed

Thangapazham RL et al; Adv Exp Med Biol 595: 343-57 (2007)

EXPL THER Curcumin is a food chemical present in tumeric (Curcuma longa) that has pharmacological activity to suppress carcinogenesis and inhibits multiple signaling pathways such as nuclear factor kappaB (NF-kappaB), cyclooxygenase-2 (Cox-2) and interleukin-8 (IL-8). Oral curcumin has poor oral bioavailability limiting its clinical activity; however, a patent pending liposomal formulation of curcumin was developed to improve drug delivery and has demonstrated activity in multiple cancers. This study was designed to determine the minimum effective dose (MED) as well as the optimal dosing schedule of liposomalcurcumin in a xenograft mouse model of human pancreatic cancer. The MED determination and optimal schedule was evaluated in female athymic nude mice injected subcutaneously with MiaPaCa-2 cells. Dosing was initiated at an average tumor size of 5mm. For the MED, mice were treated with the following dose levels of liposomal curcumin: no treatment, liposome only, 1 mg/kg, 2 mg/kg, 5 mg/kg, 10 mg/kg, 20 mg/kg and 40 mg/kg given by tail vein injection three times weekly for 28 days. For the optimum dosing schedule, three additional schedules were evaluated and compared to the control of three times weekly; daily (five days per week), every four days, and weekly for 28 days. All mice were weighed and tumor measurements taken three times weekly to evaluate toxicity and efficacy. The 20 mg/kg dose had the greatest decrease in tumor growth at 52% decrease in tumor growth when compared to no treatment control mice. MED was determined to be 20 mg/kg and was used for the optimal dosing schedule determination. Daily dosing and three times per week dosing had greater inhibition of tumor growth with no discernable difference than once weekly or every 4 day dosing. No toxicity was observed at any dose or schedule. The MED for liposomal curcumin is 20 mg/kg given once daily three times per week to achieve optimal tumor growth inhibition. This was dose recommended for additional preclinical studies to define safety and tolerability of liposomal curcumin in rat and dog models. /Liposomal curcumin/ Abstract: PubMed

Mach CM et al; Anticancer Res 29 (6): 1895-9 (2009)

EXPL THER Ionizing radiation is known to induce oxidative stress through generation of reactive oxygen species (ROS) resulting in imbalance of the pro-oxidant and antioxidant in the cells, which is suggested to culminate in cell death. The present work was aimed to evaluate the radioprotective effect ofcurcumin, a yellow pigment of turmeric on gamma-radiation-induced toxicity in primary cultures of isolated rat hepatocytes. Hepatocytes were isolated from the liver of rats by collagenase perfusion. The cellular changes were estimated using lipid peroxidative indices like thiobarbituric acid reactive substances (TBARS), the antioxidants superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and reduced glutathione (GSH), ceruloplasmin, vitamins A, E and C and uric acid. The comet assay is a sensitive and rapid technique for quantifying and analyzing DNA damage in individual cells was exposed under gamma-radiation. The increase in the severity of DNA damage was observed with the increase dose (1, 2 and 4Gy) of gamma-radiation in cultured hepatocytes. TBARS were increased significantly, whereas the levels of GSH, vitamins C, E and A, ceruloplasmin, uric acid and antioxidant enzymes were significantly decreased in gamma-irradiated hepatocytes. The maximum damage to hepatocytes was observed at 4Gy irradiation. On pretreatment withcurcumin (1, 5 and 10ug/mL) showed a significant decrease in the levels of TBARS and DNA damage. The antioxidant enzymes were increased significantly along with the levels of GSH, vitamins A, E and C, uric acid and ceruloplamin. The maximum protection of hepatocytes was observed at 10ug/mL of curcuminpretreatment. Thus, pretreatment with curcumin helps in protecting the hepatocytes against gamma-radiation-induced cellular damage and can be developed as an effective radioprotector during radiotherapy in near future. Abstract: PubMed

Srinivasan M et al; Environ Toxicol Pharmacol 24 (2): 98-105 (2007)

EXPL THER Increasing evidence suggests that many neurons may die through apoptosis in Alzheimer's disease (AD). Mitochondrial dysfunction has been implicated in this process of neuronal cell death. One promising approach for preventing AD is based upon anti-apoptosis to decrease death of nerve cells. In this study, /the authors/ observed the memory improving properties of curcumin in mice and investigated the neuroprotective effect of curcumin in vitro and in vivo. The mice were given AlCl(3) orally and injections of D-galactose intraperitoneally for 90 days to establish the AD animal model. From day 45, the curcumingroup was treated with curcumin for 45 days. Subsequently, the step-through test, neuropathological changes in the hippocampus and the expression of Bax and Bcl-2 were carried out to evaluate the effect of curcumin on the AD model mice. In cultured PC12 cells, AlCl(3) exposure induced apoptosis. The MTT assay was used to measure cell viabilities; flow cytometric analysis to survey the rate of cell apoptosis; DNA-binding fluorochrome Hoechst 33258 to observe nuclei changes in apoptotic cells and Western blot analysis of Bax, Bcl-2 to investigate the mechanisms by which curcumin protects cells from toxicity.Curcumin significantly improved the memory ability of AD mice in the step-through test, as indicated by the reduced number of step-through errors (P < 0.05) and prolonged step-through latency (P < 0.05). Curcumin also attenuated the neuropathological changes in the hippocampus and inhibited apoptosis accompanied by an increase in Bcl-2 level (P < 0.05), but the activity of Bax did not change (P > 0.05). AlCl(3) significantly reduced the viability of PC12 cells (P < 0.01). Curcumin increased cell viability in the presence of AlCl(3) (P < 0.01). The rate of apoptosis decreased significantly in the curcumin group (P < 0.05) when measured by flow cytometric analysis. Curcumin protected cells by increasing Bcl-2 level (P < 0.05), but the level of Bax did not change (P > 0.05). This study demonstrates that curcumin improves the memory ability of AD mice and inhibits apoptosis in cultured PC12 cells induced by AlCl(3). Its mechanism may involve enhancing the level of Bcl-2. Abstract: PubMed

Pan R et al; Chin Med J (Engl) 121 (9): 832-9 (2008)

EXPL THER Alzheimer's disease (AD) involves amyloid beta (Abeta) accumulation, oxidative damage, and inflammation, and risk is reduced with increased antioxidant and anti-inflammatory consumption. The phenolic yellow curry pigment curcumin has potent anti-inflammatory and antioxidant activities and can suppress oxidative damage, inflammation, cognitive deficits, and amyloid accumulation. Since the molecular structure of curcumin suggested potential Abeta binding, we investigated whether its efficacy in AD models could be explained by effects on Abeta aggregation. Under aggregating conditions in vitro,curcumin inhibited aggregation (IC(50) = 0.8 uM) as well as disaggregated fibrillar Abeta40 (IC(50) = 1 uM), indicating favorable stoichiometry for inhibition.Curcumin was a better Abeta40 aggregation inhibitor than ibuprofen and naproxen, and prevented Abeta42 oligomer formation and toxicity between 0.1 and 1.0 uM. Under EM, curcumin decreased dose dependently Abeta fibril formation beginning with 0.125 uM. The effects of curcumin did not depend on Abeta sequence but on fibril-related conformation. AD and Tg2576 mice brain sections incubated with curcumin revealed preferential labeling of amyloid plaques. In vivo studies showed that curcumin injected peripherally into aged Tg mice crossed the blood-brain barrier and bound plaques. When fed to aged Tg2576 mice with advanced amyloid accumulation, curcumin labeled plaques and reduced amyloid levels and plaque burden. Hence, curcumin directly binds small beta-amyloid species to block aggregation and fibril formation in vitro and in vivo. These data suggest that low dose curcumin effectively disaggregates Abeta as well as prevents fibril and oligomer formation, supporting the rationale for curcumin use in clinical trials preventing or treating AD. Abstract: PubMed

Yang F et al; J Biol Chem 280 (7): 5892-901 (2005)

EXPL THER The true therapeutic benefit of the use of natural products, especially acceptable dietary components such as curcumin, which can spare the normal cells and boost host immunity, has opened new horizons in cancer prevention and treatment. In our model system we used Ehrlich's ascites carcinoma cells grown in peritoneal carity of Swiss albino mice and curcumin was fed every alternative day. Here, /the authors/ report that curcumin administration to tumor-bearing mice decreased tumor cell number significantly in a dose-dependent manner. Furthermore, tumor-induced depletion of immune cell number of the host, as was evidenced from the decrease in bone marrow progenitor as well as thymic and splenic mononuclear cell numbers, was reintrated bycurcumin. In fact, curcumin inhibited tumor-induced apoptosis of both thymocytes and splenocytes thereby restoring immune cell numbers to normal level in treated Ehrlich's ascites carcinoma-bearing mice. Moreover, curcumin was not toxic to the host; rather in tumor-bearing mice it inhibited hematopoietic toxicity, acted as a hepatoprotective agent and activated depressed anti-oxidant and detoxification systems. The ability of curcumin to regress tumor as well as to protect the host from tumor-induced immunosuppression and toxicity strongly supports the candidacy of curcumin as a potential agent for the dietary therapy of cancer. Abstract: PubMed

Pal S et al; Cancer Detect Prev 29 (5): 470-8 (2005)

EXPL THER Disseminated intravascular coagulation (DIC) is a lethal situation in severe infections, characterized by the systemic formation of microthrombi complicated with bleeding tendency and organ dysfunction. Current clinical trials are not promising. In this study, /researchers/ investigated the protective effect of curcumin in a lipopolysaccharide (LPS)-induced DIC model in rats. Experimental DIC was induced by sustained infusion of LPS (10 mg/kg body weight) for 4 hr through the tail vein. Curcumin (60 mg/kg body weight) was given intraperitoneally 3 hr before LPS infusion. Results showed that, in vivo,curcumin reduced the mortality rate of LPS-infused rats by decreasing the circulating TNF-alpha levels and the consumption of peripheral platelets and plasma fibrinogen. Furthermore, in vivo curcumin also has the effect of preventing the formation of fibrin deposition in the glomeruli of kidney. These results reveal the therapeutic potential of curcumin in infection-related coagulopathy of DIC. Abstract: PubMed

Chen HW et al; J Endotoxin Res 13 (1): 15-23 (2007)

EXPL THER The present investigation was an attempt to evaluate the possible ameliorative effect of curcumin on aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice in vitro. Tissues were collected from healthy Swiss strain male albino mice Mus musculus weighing 30-35 g. The homogenates were treated with aflatoxin (2-10 mg/mL) with and without curcumin (25-200 mg/mL). The results revealed that addition of aflatoxin (2-10 mg/mL) to homogenates caused significant increase in lipid-peroxidation which was maximal at 6 mg/mL aflatoxin concentration. However, concurrent addition of aflatoxin (6 mg/mL) and curcumin (25-200 mg/mL) caused concentration-dependent amelioration in aflatoxin-induced lipid peroxidation. Abstract: PubMed

Mathuria N, Verma RJ; Acta Pol Pharm 64 (5): 413-6 (2007)


Iv & ip doses of (3)H-curcumin excreted in bile of cannulated rats. Major metab were glucuronides of tetrahydrocurcumin & hexahydrocurcumin. Minor metab was dihydroferulic acid together with traces of ferulic acid.

Mechanism of Action

Curcumin, a polyphenolic natural product, exhibits therapeutic activity against a number of diseases, attributed mainly to its chemical structure and unique physical, chemical, and biological properties. It is a diferuloyl methane molecule [1,7-bis (4-hydroxy-3- methoxyphenyl)-1,6-heptadiene-3,5-dione)] containing two ferulic acid residues joined by a methylene bridge. It has three important functionalities: an aromatic o-methoxy phenolic group, alpha, beta-unsaturated beta-diketo moiety and a seven carbon linker. Extensive research in the last two decades has provided evidence for the role of these different functional groups in its crucial biological activities. A few highlights of chemical structural features associated with the biological activity of curcumin are: The o-methoxyphenol group and methylenic hydrogen are responsible for the antioxidant activity of curcumin, and curcumin donates an electron/ hydrogen atom to reactive oxygen species. Curcumin interacts with a number of biomolecules through non-covalent and covalent binding. The hydrogen bonding and hydrophobicity of curcumin, arising from the aromatic and tautomeric structures along with the flexibility of the linker group are responsible for the non-covalent interactions. The alpha, beta-unsaturated beta-diketone moiety covalently interacts with protein thiols, through Michael reaction. The beta-diketo group forms chelates with transition metals, thereby reducing the metal induced toxicity and some of the metal complexes exhibit improved antioxidant activity as enzyme mimics. New analogues with improved activity are being developed with modifications on specific functional groups of curcumin... Abstract:PubMed

Priyadarsini KI; Curr Pharm Des 19 (11): 2093-100 (2013)

The present study demonstrates that curcumin acts as pro-oxidant and sensitizes human lung adenocarcinoma epithelial cells (A549) to apoptosis via intracellular redox status mediated pathway. Results indicated that curcumin induced cell toxicity (light microscopy and MTT assay) and apoptosis (AnnexinV-FITC/PI labeling and caspase-3 activity) in these cells. These events seem to be mediated through generation of reactive oxygen species (ROS) and superoxideradicals (SOR) and enhanced levels of lipid peroxidation. These changes were accompanied by increase in oxidized glutathione (GSSG), reduced glutathione (GSH) and gamma-glutamylcysteine synthetase (gamma-GCS) activity, but decrease in GSH/GSSG ratio. The induction of apoptosis and decrease inGSH/GSSG ratio was also accompanied by sustained phosphorylation and activation of p38 mitogen activated protein kinase (MAPK). On the other hand, addition of N-acetyl cysteine (NAC), an antioxidant, blocked the curcumin-induced ROS production and rescued malignant cells from curcumin-induced apoptosis through caspase-3 deactivation. However, L-buthionine sulfoximine (BSO), a GSH synthesis blocking agent, further enhanced curcumin-induced ROS production and apoptosis in A549 cells. Decreased GSH/GSSG ratio seems to be a crucial factor for the activation of MAPK signaling cascade bycurcumin. The study therefore, provides an insight into the molecular mechanism involved in sensitization of lung adenocarcinoma cells to apoptosis bycurcumin. Abstract: PubMed

Kaushik G et al; Indian J Exp Biol 50 (12): 853-61 (2012)
Curcumin has many pharmaceutical applications, many of which arise from its potent antioxidant properties. The present research examined the antioxidant activities of curcumin in polar solvents by a comparative study using ESR, reduction of ferric iron in aqueous medium and intracellular ROS/toxicity assays. ESR data indicated that the steric hindrance among adjacent big size groups within a galvinoxyl molecule limited the curcumin to scavenge galvinoxyl radicals effectively, while curcumin showed a powerful capacity for scavenging intracellular smaller oxidative molecules such as H2O2, HO-, ROO-. Cell viability and ROS assays demonstrated that curcumin was able to penetrate into the polar medium inside the cells and to protect them against the highly toxic and lethal effects of cumene hydroperoxide. Curcumin also showed good electron-transfer capability, with greater activity than trolox in aqueous solution. Curcumin can readily transfer electron or easily donate H-atom from two phenolic sites to scavenge free radicals. The excellent electron transfer capability of curcumin is because of its unique structure and different functional groups, including a beta-diketone and several pi electrons that have the capacity to conjugate between two phenyl rings. Therefore, since curcumin is inherently a lipophilic compound, because of its superb intracellular ROS scavenging activity, it can be used as an effective antioxidant for ROS protection within the polar cytoplasm.[Barzegar A, Moosavi-Movahedi AA; PLoS One 6 (10): e26012 (2011)] Full text:PMC3189944 Abstract: PubMed

Curcumin (diferuloylmethane), the yellow pigment in Indian saffron (Curcuma longa; also called turmeric, haldi, or haridara in the East and curry powder in the West), has been consumed by people for centuries as a dietary component and for a variety of proinflammatory ailments. Extensive research within the last decade in cell culture and in rodents has revealed that curcumin can sensitize tumors to different chemotherapeutic agents including doxorubicin, 5-FU,paclitaxel, vincristine, melphalan, butyrate, cisplatin, celecoxib, vinorelbine, gemcitabine, oxaliplatin, etoposide, sulfinosine, thalidomide, and bortezomib. Chemosensitization has been observed in cancers of the breast, colon, pancreas, gastric, liver, blood, lung, prostate, bladder, cervix, ovary, head and neck, and brain and in multiple myeloma, leukemia, and lymphoma. Similar studies have also revealed that this agent can sensitize a variety of tumors to gamma radiation including glioma, neuroblastoma, cervical carcinoma, epidermal carcinoma, prostate cancer, and colon cancer. How curcumin acts as a chemosensitizer and radiosensitizer has also been studied extensively. For example, it downregulates various growth regulatory pathways and specific genetic targets including genes for NF-kappaB, STAT3, COX2, Akt, antiapoptotic proteins, growth factor receptors, and multidrug-resistance proteins. Although it acts as a chemosensitizer and radiosensitizer for tumors in some cases, curcumin has also been shown to protect normal organs such as liver, kidney, oral mucosa, and heart from chemotherapy and radiotherapy-induced toxicity. The protective effects of curcumin appear to be mediated through its ability to induce the activation of NRF2 and induce the expression of antioxidant enzymes (e.g., hemeoxygenase-1, glutathione peroxidase, modulatory subunit of gamma-glutamyl-cysteine ligase, and NAD(P)H:quinone oxidoreductase 1, increase glutathione (a product of the modulatory subunit of gamma-glutamyl-cysteineligase), directly quench free radicals, and inhibit p300 HAT activity. Abstract: PubMed

Goel A, Aggarwal BB; Nutr Cancer 62 (7): 919-30 (2010)

Curcumin is a naturally occurring compound which is known to induce heme oxygenase 1 (HO-1), although the underlying mechanism has not been fully elucidated. This study investigates in detail the mechanism of HO-1 induction by curcumin in human hepatoma cells... Curcumin was found to induce HO-1 at doses of 10 to 25 uM. At both non-toxic and toxic doses, HO-1 induction was found to correlate with production of reactive oxygen species (ROS), suggesting a causative relationship. This was reinforced by the finding that pretreatment with the antioxidants N-acetylcysteine, vitamin E and catalase prevented HO-1 induction by curcumin. ROS production appeared to be mitochondrial in origin, and curcumin treatment resulted in depolarisation of the mitochondrial membrane potential. Nrf2 was induced by curcumin treatment, which was also partly ROS dependent. Using siRNA, Nrf2 was demonstrated to contribute to HO-1 induction. A panel of kinase inhibitors was used to examine the contribution of MAP kinases to the induction of HO-1 by curcumin. PKC and p38 MAPK activity are required for full induction of HO-1. Furthermore, curcumin also inhibited protein phosphatase activity. In conclusion, curcumin treatment results in ROS generation, activation of Nrf2 and MAP kinases and the inhibition of phosphatase activity in hepatocytes, and when curcumin is not administered in toxic doses, these multiple pathways converge to induce HO-1. Abstract: PubMed

McNally SJ et al; Int J Mol Med 19 (1): 165-72 (2007)

Curcumin is the active ingredient of turmeric that has been consumed as a dietary spice for ages. Turmeric is widely used in traditional Indian medicine to cure biliary disorders, anorexia, cough, diabetic wounds, hepatic disorders, rheumatism, and sinusitis. Extensive investigation over the last five decades has indicated that curcumin reduces blood cholesterol, prevents low-density lipoprotein oxidation, inhibits platelet aggregation, suppresses thrombosis and myocardial infarction, suppresses symptoms associated with type II diabetes, rheumatoid arthritis, multiple sclerosis, and Alzheimer's disease, inhibits HIV replication, enhances wound healing, protects from liver injury, increases bile secretion, protects from cataract formation, and protects from pulmonary toxicity and fibrosis. Evidence indicates that the divergent effects of curcumin are dependent on its pleiotropic molecular effects. These include the regulation of signal transduction pathways and direct modulation of several enzymatic activities. Most of these signaling cascades lead to the activation of transcription factors.Curcumin has been found to modulate the activity of several key transcription factors and, in turn, the cellular expression profiles. Curcumin has been shown to elicit vital cellular responses such as cell cycle arrest, apoptosis, and differentiation by activating a cascade of molecular events. In this chapter, we briefly review the effects of curcumin on transcription factors NF-KB, AP-1, Egr-1, STATs, PPAR-gamma, beta-catenin, nrf2, EpRE, p53, CBP, and androgen receptor (AR) and AR-related cofactors giving major emphasis to the molecular mechanisms of its action. Abstract: PubMed

Shishodia S et al; Adv Exp Med Biol 595: 127-48 (2007)

from MedlinePlus

What is it?

Turmeric is a plant. You probably know turmeric as the main spice in curry. It has a warm, bitter taste and is frequently used to flavor or color curry powders, mustards, butters, and cheeses. But the root of turmeric is also used widely to make medicine.

Turmeric is used for arthritis, heartburn (dyspepsia), stomach pain, diarrhea, intestinal gas, stomach bloating, loss of appetite, jaundice, liver problems and gallbladder disorders.

It is also used for headaches, bronchitis, colds, lung infections, fibromyalgia, leprosy, fever, menstrual problems, and cancer. Other uses include depression, Alzheimer’s disease, water retention, worms, and kidney problems.

Some people apply turmeric to the skin for pain, ringworm, bruising, leech bites, eye infections, inflammatory skin conditions, soreness inside of the mouth, and infected wounds.

In food and manufacturing, the essential oil of turmeric is used in perfumes, and its resin is used as a flavor and color component in foods.

Don’t confuse turmeric with Javanese turmeric root (Curcuma zedoaria).

How effective is it?

Natural Medicines Comprehensive Database rates effectiveness based on scientific evidence according to the following scale: Effective, Likely Effective, Possibly Effective, Possibly Ineffective, Likely Ineffective, Ineffective, and Insufficient Evidence to Rate.

The effectiveness ratings for TURMERIC are as follows:

Possibly effective for...

  • Osteoarthritis. Some research shows that taking turmeric extracts, alone or in combination with other herbal ingredients, can reduce the pain caused by osteoarthritis. In one study, turmeric worked about as well as ibuprofen for reducing osteoarthritis pain.

Insufficient evidence to rate effectiveness for...

  • Alzheimer’s disease. Early research shows that taking curcumin, a chemical found in turmeric, daily for 6 months does not benefit people with Alzheimer’s disease.
  • Eye inflammation (anterior uveitis). Early research suggests that taking curcumin, a chemical found in turmeric, might improve symptoms of long-term inflammation in the middle layer of the eye.
  • Colorectal cancer. Early research suggests that taking turmeric might stabilize some measures for colon cancer. There is also early evidence that taking curcumin, a chemical found in turmeric, daily for 30 days can reduce the number of precancerous glands in the colon of people at high risk of cancer.
  • Bypass surgery (coronary artery bypass graft surgery). Early research suggests that taking curcumin, a chemical found in turmeric, 3 days before surgery and continuing for 5 days after surgery can lower the risk of a heart attack following bypass surgery.
  • A type of inflammatory bowel disease called Crohn’s disease. Some evidence suggests that taking curcumin, a chemical found in turmeric, daily for one month can reduce bowel movements, diarrhea, and stomach pain in people with Crohn’s disease.
  • Diabetes. Early research suggests that taking turmeric daily for 9 months can reduce the number of people with prediabetes who develop diabetes.
  • Stomach upset (dyspepsia). Some research shows that taking turmeric by mouth might help improve an upset stomach.
  • Gum disease (gingivitis). Early research suggests that using a turmeric mouthwash is as effective as a drug-therapy mouthwash for reducing gum disease and bacteria levels in the mouth, but not for reducing plaque.
  • Stomach ulcers caused by Helicobacter pylori (H pylori) infection. Early research suggests that taking turmeric daily for 4 weeks is less effective than conventional treatment for eliminating certain bacteria (H. pylori) that can cause stomach ulcers.
  • Irritable bowel syndrome (IBS). Early research suggests that taking a turmeric extract daily for 8 weeks reduces the occurrence of IBS in people with IBS who are otherwise healthy.
  • Skin rash (Lichen planus). Taking a certain product containing chemicals found in turmeric daily for 12 days can reduce skin irritation caused by lichen planus.
  • Kidney inflammation (Lupus nephritis). Early research suggests that taking turmeric daily for 3 months can reduce blood pressure and improve kidney function in people with kidney inflammation.
  • Stomach ulcers (peptic ulcer disease). Early research suggests that taking turmeric daily for 4 weeks does help heal stomach ulcers.
  • Itchy skin (pruritus). Early research suggests that taking a specific product (C3 Complex) that contains curcumin, a chemical found in turmeric, and an extract of black or long pepper (Bioperine) can reduce skin itching and improve quality of life in people with chronic itching.
  • Rheumatoid arthritis (RA). Early research suggests that curcumin, a chemical in turmeric, might help reduce some symptoms of rheumatoid arthritis.
  • Skin wounds due to cancer. Early research suggests that applying a turmeric ointment might help to relieve odor and itching caused by wounds associated with different types of cancer.
  • Recover from surgery. Early research suggests that taking curcumin, a chemical found in turmeric, daily for up to one week after surgery can reduce pain, fatigue, and the need for pain medications.
  • Tuberculosis. Early research suggests that taking a product containing turmeric and Tinospora cordifolia can reduce bacteria levels, improve wound healing, and reduce liver toxicity in people with tuberculosis who are also receiving antituberculosis therapy.
  • A type of inflammatory bowel disease called ulcerative colitis. Early research suggests that taking curcumin, a chemical found in turmeric, daily for up to 6 months can reduce symptoms and the recurrence of ulcerative colitis when used in combination with conventional treatments.
  • Jaundice.
  • Hepatitis.
  • Diarrhea.
  • Fibromyalgia.
  • Liver and gallbladder problems.
  • Headache.
  • Menstrual problems.
  • Pain.
  • Ringworm.
  • Bruising.
  • Other conditions.

More evidence is needed to rate turmeric for these uses.

How does it work?

The chemicals in turmeric might decrease swelling (inflammation).

Are there safety concerns?

Turmeric is LIKELY SAFE when taken by mouth or applied to the skin appropriately for up to 8 months.

Turmeric usually does not cause significant side effects; however, some people can experience stomach upset, nausea, dizziness, or diarrhea.

In one report, a person who took very high amounts of turmeric, over 1500 mg twice daily, experienced a dangerous abnormal heart rhythm. However, it is unclear if turmeric was the actual cause of this side effect. Until more is known, avoid taking excessively large doses of turmeric.

Special precautions & warnings:

Pregnancy and breast-feeding: During pregnancy and while breast-feeding, turmeric is LIKELY SAFE when taken by mouth in amounts commonly found in food. However, turmeric is LIKELY UNSAFE when taken by mouth in medicinal amounts during pregnancy. It might promote a menstrual period or stimulate the uterus, putting the pregnancy at risk. Do not take medicinal amounts of turmeric if you are pregnant. There is not enough information to rate the safety of medicinal amounts of turmeric during breast-feeding. It is best not to use it.

Gallbladder problems: Turmeric can make gallbladder problems worse. Do not use turmeric if you have gallstones or a bile duct obstruction.

Bleeding problems: Taking turmeric might slow blood clotting. This might increase the risk of bruising and bleeding in people with bleeding disorders.

Diabetes: Curcumin, a chemical in turmeric, might decrease blood sugar in people with diabetes. Use with caution in people with diabetes as it might make blood sugar too low.

A stomach disorder called gastroesophageal reflux disease (GERD): Turmeric can cause stomach upset in some people. It might make stomach problems such as GERD worse. Do not take turmeric if it worsens symptoms of GERD.

Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Turmeric contains a chemical called curcumin, which might act like the hormone estrogen. In theory, turmeric might make hormone-sensitive conditions worse. However, some research shows that turmeric reduces the effects of estrogen in some hormone-sensitive cancer cells. Therefore, turmeric might have beneficial effects on hormone-sensitive conditions. Until more is known, use cautiously if you have a condition that might be made worse by exposure to hormones.

Infertility: Turmeric might lower testosterone levels and decrease sperm movement when taken by mouth by men. This might reduce fertility. Turmeric should be used cautiously by people trying to have a baby.

Iron deficiency: Taking high amounts of turmeric might prevent the absorption of iron. Turmeric should be used with caution in people with iron deficiency.

Surgery: Turmeric might slow blood clotting. It might cause extra bleeding during and after surgery. Stop using turmeric at least 2 weeks before a scheduled surgery.

Are there interactions with medications?

Be cautious with this combination.
Azulfidine EN-Tabs (Sulfasalazine)
Turmeric might increase how much Azulfidine EN-Tabs (Sulfasalazine) the body absorbs. Taking turmeric while taking Azulfidine EN-Tabs (Sulfasalazine) might increase the effects and side effects of Azulfidine EN-Tabs (Sulfasalazine).
Medications for diabetes (Antidiabetes drugs)
Turmeric might decrease blood sugar in people with type 2 diabetes. Diabetes medications are also used to lower blood sugar. Taking turmeric along with diabetes medications might cause your blood sugar to go too low. Monitor your blood sugar closely. The dose of your diabetes medication might need to be changed.

Some medications used for diabetes include glimepiride (Amaryl), glyburide (DiaBeta, Glynase PresTab, Micronase), insulin, pioglitazone (Actos), rosiglitazone (Avandia), chlorpropamide (Diabinese), glipizide (Glucotrol), tolbutamide (Orinase), and others.

Medications that slow blood clotting (Anticoagulant / Antiplatelet drugs)
Turmeric might slow blood clotting. Taking turmeric along with medications that also slow clotting might increase the chances of bruising and bleeding.

Some medications that slow blood clotting include aspirin, clopidogrel (Plavix), diclofenac (Voltaren, Cataflam, others), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, others), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, warfarin (Coumadin), and others.

Turmeric might decrease how much Talinolol the body absorbs. Taking turmeric while taking Talinolol might decrease the effects and side effects of Talinolol.
Be watchful with this combination.
Abraxane (Paclitaxel)
Turmeric might increase how much abraxane (Paclitaxel) the body absorbs. Taking turmeric while taking abraxane (Paclitaxel) might increase the effects and side effects of abraxane (Paclitaxel). However, there is not enough information to know if this is a big concern.
Large amounts of turmeric might have some of the same effects as estrogen. However, large amounts of turmeric are not as strong as estrogen pills. Taking turmeric along with estrogen pills might decrease the effects of estrogen pills.

Some estrogen pills include conjugated equine estrogens (Premarin), ethinyl estradiol, estradiol, and others.

Medications changed by the liver (Cytochrome P450 1A1 (CYP1A1) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.
br/> Some medications that are changed by the liver include chlorzoxazone, theophylline, and bufuralol.
Medications changed by the liver (Cytochrome P450 1A2 (CYP1A2) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include clozapine (Clozaril), cyclobenzaprine (Flexeril), fluvoxamine (Luvox), haloperidol (Haldol), imipramine (Tofranil), mexiletine (Mexitil), olanzapine (Zyprexa), pentazocine (Talwin), propranolol (Inderal), tacrine (Cognex), zileuton (Zyflo), zolmitriptan (Zomig), and others.

Medications changed by the liver (Cytochrome P450 3A4 (CYP3A4) substrates)
Some medications are changed and broken down by the liver. Turmeric might decrease how quickly the liver breaks down some medications. Taking turmeric along with some medications that are broken down by the liver can increase the effects and side effects of some medications. Before taking turmeric talk to your healthcare provider if you take any medications that are changed by the liver.

Some medications that are changed by the liver include some calcium channel blockers (diltiazem, nicardipine, verapamil), chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), glucocorticoids, alfentanil (Alfenta), cisapride (Propulsid), fentanyl (Sublimaze), lidocaine (Xylocaine), losartan (Cozaar), fexofenadine (Allegra), midazolam (Versed), and others.

Medications moved by pumps in cells (P-Glycoprotein Substrates)
Some medications are moved by pumps in cells. Turmeric might make these pumps less active and increase how much of some medications get absorbed by the body. This might increase the amount of some medications in the body, which could lead to more side effects. But there is not enough information to know if this is a big concern.

Some medications that are moved by these pumps include some chemotherapeutic agents (etoposide, paclitaxel, vinblastine, vincristine, vindesine), antifungals (ketoconazole, itraconazole), protease inhibitors (amprenavir, indinavir, nelfinavir, saquinavir), H2 antagonists (cimetidine, ranitidine), some calcium channel blockers (diltiazem, verapamil), digoxin, corticosteroids, erythromycin, cisapride (Propulsid), fexofenadine (Allegra), cyclosporine, loperamide (Imodium), quinidine, and others.

Noroxin (Norfloxacin)
Turmeric might increase how much noroxin (Norfloxacin) the body absorbs. Taking turmeric while taking noroxin (Norfloxacin) might increase the effects and side effects of noroxin (Norfloxacin).
Taxotere (Docetaxel)
Turmeric might increase how much taxotere (Docetaxel) the body absorbs. Taking turmeric while taking taxotere (Docetaxel) might increase the effects and side effects of taxotere (Docetaxel).

Are there interactions with herbs and supplements?

Herbs and supplements that might lower blood sugar
Turmeric might lower blood sugar. Using it along with other herbs and supplements that have the same effect might cause blood sugar to drop too low in some people. Some of these products include devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, Siberian ginseng, and others.
Herbs and supplements that might slow blood clotting
Turmeric might slow blood clotting. Taking turmeric along with herbs that also slow clotting might increase the chances of bruising and bleeding. These herbs include angelica, clove, danshen, garlic, ginger, ginkgo, Panax ginseng, red clover, willow, and others.
Turmeric and curcumin, a chemical found in turmeric, might prevent the body from absorbing iron. This does not appear to occur when turmeric is consumed in levels commonly found in food. However, in theory, taking high doses of turmeric or curcumin might decrease the body's absorption of iron.

Are there interactions with foods?

There are no known interactions with foods.

What dose is used?

The following doses have been studied in scientific research:

BY MOUTH: For upset stomach (dyspepsia): 500 mg of turmeric four times daily.
For osteoarthritis: 500 mg twice daily of a specific turmeric extract (Meriva, Indena); 500 mg four times daily of a non-commercial product has also been used.
For rheumatoid arthritis (RA): 500mg twice daily of a specific formulation of the turmeric constituent, curcumin (BCM-95®, Arjuna Natural Extracts, India), has been used.

Other names

Curcuma, Curcuma aromatica, Curcuma domestica, Curcumae longa, Curcumae Longae Rhizoma, Curcumin, Curcumine, Curcuminoid, Curcuminoïde, Curcuminoïdes, Curcuminoids, Halada, Haldi, Haridra, Indian Saffron, Nisha, Pian Jiang Huang, Racine de Curcuma, Radix Curcumae, Rajani, Rhizoma Cucurmae Longae, Safran Bourbon, Safran de Batallita, Safran des Indes, Turmeric Root, Yu Jin.


To learn more about how this article was written, please see the Natural Medicines Comprehensive Database methodology.


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  317. Gupta, S. K., Kumar, B., Nag, T. C., Agrawal, S. S., Agrawal, R., Agrawal, P., Saxena, R., and Srivastava, S. Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms. J Ocul.Pharmacol Ther 2011;27:123-130. View abstract.
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  322. Sawatpanich, T., Petpiboolthai, H., Punyarachun, B., and Anupunpisit, V. Effect of curcumin on vascular endothelial growth factor expression in diabetic mice kidney induced by streptozotocin. J Med Assoc Thai 2010;93 Suppl 2:S1-S8. View abstract.
  323. Gou, M., Men, K., Shi, H., Xiang, M., Zhang, J., Song, J., Long, J., Wan, Y., Luo, F., Zhao, X., and Qian, Z. Curcumin-loaded biodegradable polymeric micelles for colon cancer therapy in vitro and in vivo. Nanoscale. 2011;3:1558-1567. View abstract.
  324. Gomez-Pinilla, F. The combined effects of exercise and foods in preventing neurological and cognitive disorders. Prev Med 2011;52 Suppl 1:S75-S80. View abstract.
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  329. Teiten, M. H., Gaascht, F., Cronauer, M., Henry, E., Dicato, M., and Diederich, M. Anti-proliferative potential of curcumin in androgen-dependent prostate cancer cells occurs through modulation of the Wingless signaling pathway. Int J Oncol 2011;38:603-611. View abstract.
  330. Thephinlap, C., Phisalaphong, C., Lailerd, N., Chattipakorn, N., Winichagoon, P., Vadolus, J., Fucharoen, S., Porter, J. B., and Srichairatanakool, S. Reversal of cardiac iron loading and dysfunction in thalassemic mice by curcuminoids. Med Chem 2011;7:62-69. View abstract.
  331. Lin, M. S., Hung, K. S., Chiu, W. T., Sun, Y. Y., Tsai, S. H., Lin, J. W., and Lee, Y. H. Curcumin enhances neuronal survival in N-methyl-d-aspartic acid toxicity by inducing RANTES expression in astrocytes via PI-3K and MAPK signaling pathways. Prog.Neuropsychopharmacol.Biol Psychiatry 6-1-2011;35:931-938. View abstract.
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  337. Kakkar, V., Singh, S., Singla, D., Sahwney, S., Chauhan, A. S., Singh, G., and Kaur, I. P. Pharmacokinetic applicability of a validated liquid chromatography tandem mass spectroscopy method for orally administered curcumin loaded solid lipid nanoparticles to rats. J Chromatogr.B Analyt.Technol Biomed.Life Sci 12-15-2010;878:3427-3431. View abstract.
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  340. Chen, L. X., He, Y. J., Zhao, S. Z., Wu, J. G., Wang, J. T., Zhu, L. M., Lin, T. T., Sun, B. C., and Li, X. R. Inhibition of tumor growth and vasculogenic mimicry by curcumin through down-regulation of the EphA2/PI3K/MMP pathway in a murine choroidal melanoma model. Cancer Biol Ther 1-15-2011;11:229-235. View abstract.
  341. Schrader, C., Schiborr, C., Frank, J., and Rimbach, G. Curcumin induces paraoxonase 1 in cultured hepatocytes in vitro but not in mouse liver in vivo. Br J Nutr 2011;105:167-170. View abstract.
  342. Ma, J., Phillips, L., Wang, Y., Dai, T., LaPage, J., Natarajan, R., and Adler, S. G. Curcumin activates the p38MPAK-HSP25 pathway in vitro but fails to attenuate diabetic nephropathy in DBA2J mice despite urinary clearance documented by HPLC. BMC Complement Altern Med 2010;10:67. View abstract.
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  344. Zhang, Y., Cao, H., Hu, Y. Y., Wang, H., and Zhang, C. J. Inhibitory effect of curcumin on angiogenesis in ectopic endometrium of rats with experimental endometriosis. Int J Mol.Med 2011;27:87-94. View abstract.
  345. Seo, S. W., Bae, G. S., Kim, S. G., Yun, S. W., Kim, M. S., Yun, K. J., Park, R. K., Song, H. J., and Park, S. J. Protective effects of Curcuma longa against cerulein-induced acute pancreatitis and pancreatitis-associated lung injury. Int J Mol.Med 2011;27:53-61.View abstract.
  346. Maher, D. M., Bell, M. C., O'Donnell, E. A., Gupta, B. K., Jaggi, M., and Chauhan, S. C. Curcumin suppresses human papillomavirus oncoproteins, restores p53, Rb, and PTPN13 proteins and inhibits benzo[a]pyrene-induced upregulation of HPV E7. Mol.Carcinog. 2011;50:47-57. View abstract.
  347. Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr Cancer 2010;62:1137-1141. View abstract.
  348. El-Beshbishy, H. A., Mohamadin, A. M., Nagy, A. A., and Abdel-Naim, A. B. Amelioration of tamoxifen-induced liver injury in rats by grape seed extract, black seed extract and curcumin. Indian J Exp Biol 2010;48:280-288. View abstract.
  349. Kim, T. H., Jiang, H. H., Youn, Y. S., Park, C. W., Tak, K. K., Lee, S., Kim, H., Jon, S., Chen, X., and Lee, K. C. Preparation and characterization of water-soluble albumin-bound curcumin nanoparticles with improved antitumor activity. Int J Pharm 1-17-2011;403(1-2):285-291. View abstract.
  350. Tang, Y. and Chen, A. Curcumin prevents leptin raising glucose levels in hepatic stellate cells by blocking translocation of glucose transporter-4 and increasing glucokinase. Br J Pharmacol 2010;161:1137-1149. View abstract.
  351. Agarwal, B. B. Do dietary spices impair the patient-reported outcomes for stapled hemorrhoidopexy? A randomized controlled study. Surg Endosc. 2011;25:1535-1540. View abstract.
  352. Voznesens'ka, T. I., Bryzhina, T. M., Sukhina, V. S., Makohon, N. V., and Aleksieieva, I. M. [Effect of NF-kappaB activation inhibitor curcumin on the oogenesis and follicular cell death in immune ovarian failure in mice]. Fiziol.Zh. 2010;56:96-101. View abstract.
  353. Ahmed, T., Gilani, A. H., Hosseinmardi, N., Semnanian, S., Enam, S. A., and Fathollahi, Y. Curcuminoids rescue long-term potentiation impaired by amyloid peptide in rat hippocampal slices. Synapse 2011;65:572-582. View abstract.
  354. Sun, Z. J., Chen, G., Zhang, W., Hu, X., Liu, Y., Zhou, Q., Zhu, L. X., and Zhao, Y. F. Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-kappaB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IkappaB kinase complex signaling axis in adenoid cystic carcinoma. Mol.Pharmacol 2011;79:106-118. View abstract.
  355. Khuwaja, G., Khan, M. M., Ishrat, T., Ahmad, A., Raza, S. S., Ashafaq, M., Javed, H., Khan, M. B., Khan, A., Vaibhav, K., Safhi, M. M., and Islam, F. Neuroprotective effects of curcumin on 6-hydroxydopamine-induced Parkinsonism in rats: behavioral, neurochemical and immunohistochemical studies. Brain Res 1-12-2011;1368:254-263. View abstract.
  356. Rungseesantivanon, S., Thenchaisri, N., Ruangvejvorachai, P., and Patumraj, S. Curcumin supplementation could improve diabetes-induced endothelial dysfunction associated with decreased vascular superoxide production and PKC inhibition. BMC Complement Altern Med 2010;10:57. View abstract.
  357. Singh, M. and Singh, N. Curcumin counteracts the proliferative effect of estradiol and induces apoptosis in cervical cancer cells. Mol.Cell Biochem 2011;347(1-2):1-11. View abstract.
  358. Kakkar, V., Singh, S., Singla, D., and Kaur, I. P. Exploring solid lipid nanoparticles to enhance the oral bioavailability of curcumin. Mol.Nutr Food Res 2011;55:495-503. View abstract.
  359. Lima, C. F., Pereira-Wilson, C., and Rattan, S. I. Curcumin induces heme oxygenase-1 in normal human skin fibroblasts through redox signaling: relevance for anti-aging intervention. Mol.Nutr Food Res 2011;55:430-442. View abstract.
  360. Wickenberg, J., Ingemansson, S. L., and Hlebowicz, J. Effects of Curcuma longa (turmeric) on postprandial plasma glucose and insulin in healthy subjects. Nutr J 2010;9:43. View abstract.
  361. Wei, S., Xu, H., Xia, D., and Zhao, R. Curcumin attenuates the effects of transport stress on serum cortisol concentration, hippocampal NO production, and BDNF expression in the pig. Domest.Anim Endocrinol 2010;39:231-239. View abstract.
  362. Lee, H. S., Li, L., Kim, H. K., Bilehal, D., Li, W., Lee, D. S., and Kim, Y. H. The protective effects of Curcuma longa Linn. extract on carbon tetrachloride-induced hepatotoxicity in rats via upregulation of Nrf2. J Microbiol.Biotechnol. 2010;20:1331-1338. View abstract.
  363. Bhartiya, U. S., Joseph, L. J., Raut, Y. S., and Rao, B. S. Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice. Indian J Exp Biol 2010;48:566-571. View abstract.
  364. Schiborr, C., Eckert, G. P., Weissenberger, J., Muller, W. E., Schwamm, D., Grune, T., Rimbach, G., and Frank, J. Cardiac oxidative stress and inflammation are similar in SAMP8 and SAMR1 mice and unaltered by curcumin and Ginkgo biloba extract intake. Curr Pharm Biotechnol. 2010;11:861-867. View abstract.
  365. Singh, R. S., Das, U., Dimmock, J. R., and Alcorn, J. A general HPLC-UV method for the quantitative determination of curcumin analogues containing the 1,5-diaryl-3-oxo-1,4-pentadienyl pharmacophore in rat biomatrices. J Chromatogr.B Analyt.Technol Biomed.Life Sci 10-15-2010;878:2796-2802. View abstract.
  366. Matteucci, A., Cammarota, R., Paradisi, S., Varano, M., Balduzzi, M., Leo, L., Bellenchi, G. C., De, Nuccio C., Carnovale-Scalzo, G., Scorcia, G., Frank, C., Mallozzi, C., Di Stasi, A. M., Visentin, S., and Malchiodi-Albedi, F. Curcumin protects against NMDA-induced toxicity: a possible role for NR2A subunit. Invest Ophthalmol.Vis.Sci 2011;52:1070-1077. View abstract.
  367. Kanai, M., Yoshimura, K., Asada, M., Imaizumi, A., Suzuki, C., Matsumoto, S., Nishimura, T., Mori, Y., Masui, T., Kawaguchi, Y., Yanagihara, K., Yazumi, S., Chiba, T., Guha, S., and Aggarwal, B. B. A phase I/II study of gemcitabine-based chemotherapy plus curcumin for patients with gemcitabine-resistant pancreatic cancer. Cancer Chemother.Pharmacol 2011;68:157-164. View abstract.
  368. Villegas, I., Sanchez-Fidalgo, S., and de la Lastra, C. A. Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Mol.Nutr Food Res 2011;55:259-267. View abstract.
  369. Mehla, J., Reeta, K. H., Gupta, P., and Gupta, Y. K. Protective effect of curcumin against seizures and cognitive impairment in a pentylenetetrazole-kindled epileptic rat model. Life Sci 11-20-2010;87(19-22):596-603. View abstract.
  370. Prakobwong, S., Khoontawad, J., Yongvanit, P., Pairojkul, C., Hiraku, Y., Sithithaworn, P., Pinlaor, P., Aggarwal, B. B., and Pinlaor, S. Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation-mediated molecular events related to multistep carcinogenesis. Int J Cancer 7-1-2011;129:88-100. View abstract.
  371. Dandekar, P. P., Jain, R., Patil, S., Dhumal, R., Tiwari, D., Sharma, S., Vanage, G., and Patravale, V. Curcumin-loaded hydrogel nanoparticles: application in anti-malarial therapy and toxicological evaluation. J Pharm Sci 2010;99:4992-5010. View abstract.
  372. Karatepe, O., Acet, E., Battal, M., Adas, G., Kemik, A., Altiok, M., Kamali, G., Koculu, S., Catay, A., Kamali, S., and Karahan, S. Effects of glutamine and curcumin on bacterial translocation in jaundiced rats. World J Gastroenterol. 9-14-2010;16:4313-4320.View abstract.
  373. Sharma, S., Ying, Z., and Gomez-Pinilla, F. A pyrazole curcumin derivative restores membrane homeostasis disrupted after brain trauma. Exp Neurol. 2010;226:191-199. View abstract.
  374. Duan, J., Zhang, Y., Han, S., Chen, Y., Li, B., Liao, M., Chen, W., Deng, X., Zhao, J., and Huang, B. Synthesis and in vitro/in vivo anti-cancer evaluation of curcumin-loaded chitosan/poly(butyl cyanoacrylate) nanoparticles. Int J Pharm 11-15-2010;400(1-2):211-220. View abstract.
  375. Yousef, M. I., Omar, S. A., El-Guendi, M. I., and Abdelmegid, L. A. Potential protective effects of quercetin and curcumin on paracetamol-induced histological changes, oxidative stress, impaired liver and kidney functions and haematotoxicity in rat. Food Chem Toxicol 2010;48:3246-3261. View abstract.
  376. Dayton, A., Selvendiran, K., Kuppusamy, M. L., Rivera, B. K., Meduru, S., Kalai, T., Hideg, K., and Kuppusamy, P. Cellular uptake, retention and bioabsorption of HO-3867, a fluorinated curcumin analog with potential antitumor properties. Cancer Biol Ther 2010;10:1027-1032. View abstract.
  377. Sahebkar, A. Molecular mechanisms for curcumin benefits against ischemic injury. Fertil.Steril. 2010;94:e75-e76. View abstract.
  378. Wu, X., Xu, J., Huang, X., and Wen, C. Self-microemulsifying drug delivery system improves curcumin dissolution and bioavailability. Drug Dev Ind Pharm 2011;37:15-23. View abstract.
  379. Quiroga, A., Quiroga, P. L., Martinez, E., Soria, E. A., and Valentich, M. A. Anti-breast cancer activity of curcumin on the human oxidation-resistant cells ZR-75-1 with gamma-glutamyltranspeptidase inhibition. J Exp Ther Oncol 2010;8:261-266. View abstract.
  380. Mohankumar, S. and McFarlane, J. R. An aqueous extract of Curcuma longa (turmeric) rhizomes stimulates insulin release and mimics insulin action on tissues involved in glucose homeostasis in vitro. Phytother Res 2011;25:396-401. View abstract.
  381. Sintara, K., Thong-Ngam, D., Patumraj, S., Klaikeaw, N., and Chatsuwan, T. Curcumin suppresses gastric NF-kappaB activation and macromolecular leakage in Helicobacter pylori-infected rats. World J Gastroenterol. 8-28-2010;16:4039-4046. View abstract.
  382. Yadav, B., Taurin, S., Rosengren, R. J., Schumacher, M., Diederich, M., Somers-Edgar, T. J., and Larsen, L. Synthesis and cytotoxic potential of heterocyclic cyclohexanone analogues of curcumin. Bioorg.Med Chem 9-15-2010;18:6701-6707. View abstract.
  383. Yan, Y. D., Kim, D. H., Sung, J. H., Yong, C. S., and Choi, H. G. Enhanced oral bioavailability of docetaxel in rats by four consecutive days of pre-treatment with curcumin. Int J Pharm 10-31-2010;399(1-2):116-120. View abstract.
  384. Hsu, Y. C., Chen, M. J., Yu, Y. M., Ko, S. Y., and Chang, C. C. Suppression of TGF-beta1/SMAD pathway and extracellular matrix production in primary keloid fibroblasts by curcuminoids: its potential therapeutic use in the chemoprevention of keloid. Arch Dermatol Res 2010;302:717-724. View abstract.
  385. Wright, L. E., Frye, J. B., Timmermann, B. N., and Funk, J. L. Protection of trabecular bone in ovariectomized rats by turmeric (Curcuma longa L.) is dependent on extract composition. J Agric.Food Chem 9-8-2010;58:9498-9504. View abstract.
  386. Tan, X., Sidell, N., Mancini, A., Huang, R. P., Shenming, Wang, Horowitz, I. R., Liotta, D. C., Taylor, R. N., and Wieser, F. Multiple anticancer activities of EF24, a novel curcumin analog, on human ovarian carcinoma cells. Reprod.Sci 2010;17:931-940. View abstract.
  387. Vachharajani, V., Wang, S. W., Mishra, N., El, Gazzar M., Yoza, B., and McCall, C. Curcumin modulates leukocyte and platelet adhesion in murine sepsis. Microcirculation. 2010;17:407-416. View abstract.
  388. Wong, T. S., Chan, W. S., Li, C. H., Liu, R. W., Tang, W. W., Tsao, S. W., Tsang, R. K., Ho, W. K., Wei, W. I., and Chan, J. Y. Curcumin alters the migratory phenotype of nasopharyngeal carcinoma cells through up-regulation of E-cadherin. Anticancer Res 2010;30:2851-2856. View abstract.
  389. Choi, H. Y., Lim, J. E., and Hong, J. H. Curcumin interrupts the interaction between the androgen receptor and Wnt/beta-catenin signaling pathway in LNCaP prostate cancer cells. Prostate Cancer Prostatic.Dis 2010;13:343-349. View abstract.
  390. Ibrahim, A., El-Meligy, A., Fetaih, H., Dessouki, A., Stoica, G., and Barhoumi, R. Effect of curcumin and Meriva on the lung metastasis of murine mammary gland adenocarcinoma. In Vivo 2010;24:401-408. View abstract.
  391. Boonrao, M., Yodkeeree, S., Ampasavate, C., Anuchapreeda, S., and Limtrakul, P. The inhibitory effect of turmeric curcuminoids on matrix metalloproteinase-3 secretion in human invasive breast carcinoma cells. Arch Pharm Res 2010;33:989-998. View abstract.
  392. Tang, Y. and Chen, A. Curcumin protects hepatic stellate cells against leptin-induced activation in vitro by accumulating intracellular lipids. Endocrinology 2010;151:4168-4177. View abstract.
  393. Setthacheewakul, S., Mahattanadul, S., Phadoongsombut, N., Pichayakorn, W., and Wiwattanapatapee, R. Development and evaluation of self-microemulsifying liquid and pellet formulations of curcumin, and absorption studies in rats. Eur J Pharm Biopharm. 2010;76:475-485. View abstract.
  394. Belcaro, G., Cesarone, M. R., Dugall, M., Pellegrini, L., Ledda, A., Grossi, M. G., Togni, S., and Appendino, G. Product-evaluation registry of Meriva(R), a curcumin-phosphatidylcholine complex, for the complementary management of osteoarthritis. Panminerva Med 2010;52(2 Suppl 1):55-62. View abstract.
  395. Peeyush, Kumar T., Antony, S., Soman, S., Kuruvilla, K. P., George, N., and Paulose, C. S. Role of curcumin in the prevention of cholinergic mediated cortical dysfunctions in streptozotocin-induced diabetic rats. Mol.Cell Endocrinol 1-1-2011;331:1-10. View abstract.
  396. Yang, M. W., Wang, T. H., Yan, P. P., Chu, L. W., Yu, J., Gao, Z. D., Li, Y. Z., and Guo, B. L. Curcumin improves bone microarchitecture and enhances mineral density in APP/PS1 transgenic mice. Phytomedicine. 1-15-2011;18(2-3):205-213. View abstract.
  397. Ammon, H. P. and Wahl, M. A. Pharmacology of Curcuma longa. Planta Med. 1991;57:1-7. View abstract.
  398. Larmonier, C. B., Midura-Kiela, M. T., Ramalingam, R., Laubitz, D., Janikashvili, N., Larmonier, N., Ghishan, F. K., and Kiela, P. R. Modulation of neutrophil motility by curcumin: implications for inflammatory bowel disease. Inflamm.Bowel.Dis 2011;17:503-515.View abstract.
  399. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., and Kazeminejad, B. Neuroprotective effects of the polyphenolic antioxidant agent, Curcumin, against homocysteine-induced cognitive impairment and oxidative stress in the rat. Pharmacol Biochem Behav 2010;96:378-385. View abstract.
  400. Biswas, J., Roy, S., Mukherjee, S., Sinha, D., and Roy, M. Indian spice curcumin may be an effective strategy to combat the genotoxicity of arsenic in Swiss albino mice. Asian Pac.J Cancer Prev 2010;11:239-247. View abstract.
  401. Tang, H., Murphy, C. J., Zhang, B., Shen, Y., Van Kirk, E. A., Murdoch, W. J., and Radosz, M. Curcumin polymers as anticancer conjugates. Biomaterials 2010;31:7139-7149. View abstract.
  402. Bielak-Zmijewska, A., Sikora-Polaczek, M., Nieznanski, K., Mosieniak, G., Kolano, A., Maleszewski, M., Styrna, J., and Sikora, E. Curcumin disrupts meiotic and mitotic divisions via spindle impairment and inhibition of CDK1 activity. Cell Prolif. 2010;43:354-364. View abstract.
  403. Rai, B., Kaur, J., Jacobs, R., and Singh, J. Possible action mechanism for curcumin in pre-cancerous lesions based on serum and salivary markers of oxidative stress. J Oral Sci. 2010;52:251-256. View abstract.
  404. Jena, S. and Chainy, G. B. Regulation of expression of antioxidant enzymes by vitamin E and curcumin in L: -thyroxine-induced oxidative stress in rat renal cortex. Mol.Biol.Rep. 6-24-2010; View abstract.
  405. Yallapu, M. M., Jaggi, M., and Chauhan, S. C. Poly(beta-cyclodextrin)/Curcumin Self-Assembly: A Novel Approach to Improve Curcumin Delivery and its Therapeutic Efficacy in Prostate Cancer Cells. Macromol.Biosci. 6-22-2010; View abstract.
  406. Sun, D., Zhuang, X., Xiang, X., Liu, Y., Zhang, S., Liu, C., Barnes, S., Grizzle, W., Miller, D., and Zhang, H. G. A Novel Nanoparticle Drug Delivery System: The Anti-inflammatory Activity of Curcumin Is Enhanced When Encapsulated in Exosomes. Mol.Ther. 6-22-2010; View abstract.
  407. Bharti, A. C., Panigrahi, A., Sharma, P. K., Gupta, N., Kumar, R., Shukla, S., Bhowmik, D. M., Agarwal, S. K., Guleria, S., and Mehra, N. K. Clinical relevance of curcumin-induced immunosuppression in living-related donor renal transplant: an in vitro analysis. Exp.Clin Transplant. 2010;8:161-171. View abstract.
  408. Ataie, A., Sabetkasaei, M., Haghparast, A., Moghaddam, A. H., Ataee, R., and Moghaddam, S. N. Curcumin Exerts Neuroprotective Effects Against Homocysteine Intracerebroventricular Injection-Induced Cognitive Impairment and Oxidative Stress in Rat Brain. J Med.Food 6-16-2010; View abstract.
  409. Jutooru, I., Chadalapaka, G., Lei, P., and Safe, S. Inhibition of NF{kappa}B and pancreatic cancer cell and tumor growth by curcumin is dependent on specificity protein downregulation. J Biol.Chem. 6-9-2010; View abstract.
  410. Ahmed, T., Enam, S. A., and Gilani, A. H. Curcuminoids enhance memory in an amyloid-infused rat model of Alzheimer's disease. Neuroscience 6-9-2010; View abstract.
  411. Cemil, B., Topuz, K., Demircan, M. N., Kurt, G., Tun, K., Kutlay, M., Ipcioglu, O., and Kucukodaci, Z. Curcumin improves early functional results after experimental spinal cord injury. Acta Neurochir.(Wien.) 6-10-2010; View abstract.
  412. Pisano, M., Pagnan, G., Dettori, M. A., Cossu, S., Caffa, I., Sassu, I., Emionite, L., Fabbri, D., Cilli, M., Pastorino, F., Palmieri, G., Delogu, G., Ponzoni, M., and Rozzo, C. Enhanced anti-tumor activity of a new curcumin-related compound against melanoma and neuroblastoma cells. Mol.Cancer 6-3-2010;9:137. View abstract.
  413. Suresh, D. and Srinivasan, K. Tissue distribution & elimination of capsaicin, piperine & curcumin following oral intake in rats. Indian J Med.Res 2010;131:682-691. View abstract.
  414. Kumar, T. P., Antony, S., Gireesh, G., George, N., and Paulose, C. S. Curcumin modulates dopaminergic receptor, CREB and phospholipase c gene expression in the cerebral cortex and cerebellum of streptozotocin induced diabetic rats. J Biomed.Sci. 2010;17:43. View abstract.
  415. Sharma, V., Nehru, B., Munshi, A., and Jyothy, A. Antioxidant potential of curcumin against oxidative insult induced by pentylenetetrazol in epileptic rats. Methods Find.Exp.Clin Pharmacol 2010;32:227-232. View abstract.
  416. Ide, H., Tokiwa, S., Sakamaki, K., Nishio, K., Isotani, S., Muto, S., Hama, T., Masuda, H., and Horie, S. Combined inhibitory effects of soy isoflavones and curcumin on the production of prostate-specific antigen. Prostate 7-1-2010;70:1127-1133. View abstract.
  417. Zhao, J. Y., Lu, N., Yan, Z., and Wang, N. SAHA and curcumin combinations co-enhance histone acetylation in human cancer cells but operate antagonistically in exerting cytotoxic effects. J Asian Nat.Prod.Res 2010;12:335-348. View abstract.
  418. Chen, Y., Liu, W. H., Chen, B. L., Fan, L., Han, Y., Wang, G., Hu, D. L., Tan, Z. R., Zhou, G., Cao, S., and Zhou, H. H. Plant polyphenol curcumin significantly affects CYP1A2 and CYP2A6 activity in healthy, male Chinese volunteers. Ann.Pharmacother. 2010;44:1038-1045. View abstract.
  419. Yadav, R. S., Shukla, R. K., Sankhwar, M. L., Patel, D. K., Ansari, R. W., Pant, A. B., Islam, F., and Khanna, V. K. Neuroprotective effect of curcumin in arsenic-induced neurotoxicity in rats. Neurotoxicology 5-11-2010; View abstract.
  420. Rajagopalan, R., Sridharana, S., and Menon, V. P. Hepatoprotective role of bis-demethoxy curcumin analog on the expression of matrix metalloproteinase induced by alcohol and polyunsaturated fatty acid in rats. Toxicol Mech.Methods 2010;20:252-259.View abstract.
  421. Shahani, K., Swaminathan, S. K., Freeman, D., Blum, A., Ma, L., and Panyam, J. Injectable sustained release microparticles of curcumin: a new concept for cancer chemoprevention. Cancer Res 6-1-2010;70:4443-4452. View abstract.
  422. Yallapu, M. M., Jaggi, M., and Chauhan, S. C. beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. Colloids Surf.B Biointerfaces. 8-1-2010;79:113-125. View abstract.
  423. Koosirirat, C., Linpisarn, S., Changsom, D., Chawansuntati, K., and Wipasa, J. Investigation of the anti-inflammatory effect of Curcuma longa in Helicobacter pylori-infected patients. Int Immunopharmacol. 2010;10:815-818. View abstract.
  424. Chen, K. H., Chao, D., Liu, C. F., Chen, C. F., and Wang, D. Curcumin attenuates airway hyperreactivity induced by ischemia-reperfusion of the pancreas in rats. Transplant.Proc. 2010;42:744-747. View abstract.
  425. Lee, J. C., Kinniry, P. A., Arguiri, E., Serota, M., Kanterakis, S., Chatterjee, S., Solomides, C. C., Javvadi, P., Koumenis, C., Cengel, K. A., and Christofidou-Solomidou, M. Dietary curcumin increases antioxidant defenses in lung, ameliorates radiation-induced pulmonary fibrosis, and improves survival in mice. Radiat.Res 2010;173:590-601. View abstract.
  426. Pinlaor, S., Prakobwong, S., Hiraku, Y., Pinlaor, P., Laothong, U., and Yongvanit, P. Reduction of periductal fibrosis in liver fluke-infected hamsters after long-term curcumin treatment. Eur.J Pharmacol 7-25-2010;638(1-3):134-141. View abstract.
  427. He, L. F., Chen, H. J., Qian, L. H., Chen, G. Y., and Buzby, J. S. Curcumin protects pre-oligodendrocytes from activated microglia in vitro and in vivo. Brain Res 6-21-2010;1339:60-69. View abstract.
  428. Jung, I. D., Jeong, Y. I., Lee, C. M., Noh, K. T., Jeong, S. K., Chun, S. H., Choi, O. H., Park, W. S., Han, J., Shin, Y. K., Kim, H. W., Yun, C. H., and Park, Y. M. COX-2 and PGE2 signaling is essential for the regulation of IDO expression by curcumin in murine bone marrow-derived dendritic cells. Int.Immunopharmacol. 4-22-2010; View abstract.
  429. El Deen, N. A. and Eid, M. Efficacy of curcumin to reduce hepatic damage induced by alcohol and thermally treated oil in rats. Vet.Ital. 2010;46:83-92. View abstract.
  430. Lin, Y. C., Chen, H. W., Kuo, Y. C., Chang, Y. F., Lee, Y. J., and Hwang, J. J. Therapeutic efficacy evaluation of curcumin on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am.J Chin Med. 2010;38:343-358. View abstract.
  431. Hua, W. F., Fu, Y. S., Liao, Y. J., Xia, W. J., Chen, Y. C., Zeng, Y. X., Kung, H. F., and Xie, D. Curcumin induces down-regulation of EZH2 expression through the MAPK pathway in MDA-MB-435 human breast cancer cells. Eur.J Pharmacol 7-10-2010;637(1-3):16-21. View abstract.
  432. Abdel Fattah, E. A., Hashem, H. E., Ahmed, F. A., Ghallab, M. A., Varga, I., and Polak, S. Prophylactic role of curcumin against cyclosporine-induced nephrotoxicity: Histological and immunohistological study. Gen.Physiol Biophys. 2010;29:85-94. View abstract.
  433. Rinwa, P., Kaur, B., Jaggi, A. S., and Singh, N. Involvement of PPAR-gamma in curcumin-mediated beneficial effects in experimental dementia. Naunyn Schmiedebergs Arch.Pharmacol 2010;381:529-539. View abstract.
  434. Hilchie, A. L., Furlong, S. J., Sutton, K., Richardson, A., Robichaud, M. R., Giacomantonio, C. A., Ridgway, N. D., and Hoskin, D. W. Curcumin-induced apoptosis in PC3 prostate carcinoma cells is caspase-independent and involves cellular ceramide accumulation and damage to mitochondria. Nutr.Cancer 2010;62:379-389. View abstract.
  435. Okazaki, Y., Han, Y., Kayahara, M., Watanabe, T., Arishige, H., and Kato, N. Consumption of curcumin elevates fecal immunoglobulin a, an index of intestinal immune function, in rats fed a high-fat diet. J Nutr.Sci.Vitaminol.(Tokyo) 2010;56:68-71.View abstract.
  436. Hu, G. X., Liang, G., Chu, Y., Li, X., Lian, Q. Q., Lin, H., He, Y., Huang, Y., Hardy, D. O., and Ge, R. S. Curcumin derivatives inhibit testicular 17beta-hydroxysteroid dehydrogenase 3. Bioorg.Med.Chem.Lett. 4-15-2010;20:2549-2551. View abstract.
  437. Wu, H., Hsieh, M. C., Lo, C. Y., Liu, C. B., Sang, S., Ho, C. T., and Pan, M. H. 6-Shogaol is more effective than 6-gingerol and curcumin in inhibiting 12-O-tetradecanoylphorbol 13-acetate-induced tumor promotion in mice. Mol.Nutr.Food Res 3-24-2010;View abstract.
  438. Baghdasaryan, A., Claudel, T., Kosters, A., Gumhold, J., Silbert, D., Thuringer, A., Leski, K., Fickert, P., Karpen, S. J., and Trauner, M. Curcumin improves sclerosing cholangitis in Mdr2-/- mice by inhibition of cholangiocyte inflammatory response and portal myofibroblast proliferation. Gut 2010;59:521-530. View abstract.
  439. Hashem, M. M., Atta, A. H., Arbid, M. S., Nada, S. A., and Asaad, G. F. Immunological studies on Amaranth, Sunset Yellow and Curcumin as food colouring agents in albino rats. Food Chem.Toxicol 2010;48:1581-1586. View abstract.
  440. Saydmohammed, M., Joseph, D., and Syed, V. Curcumin suppresses constitutive activation of STAT-3 by up-regulating protein inhibitor of activated STAT-3 (PIAS-3) in ovarian and endometrial cancer cells. J Cell Biochem. 5-15-2010;110:447-456. View abstract.
  441. Yu, S., Zheng, W., Xin, N., Chi, Z. H., Wang, N. Q., Nie, Y. X., Feng, W. Y., and Wang, Z. Y. Curcumin prevents dopaminergic neuronal death through inhibition of the c-Jun N-terminal kinase pathway. Rejuvenation.Res 2010;13:55-64. View abstract.
  442. Agarwal, R., Goel, S. K., and Behari, J. R. Detoxification and antioxidant effects of curcumin in rats experimentally exposed to mercury. J Appl.Toxicol 3-12-2010; View abstract.
  443. Li, J. M., Li, Y. C., Kong, L. D., and Hu, Q. H. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010;51:1555-1566. View abstract.
  444. Pyrzanowska, J., Piechal, A., Blecharz-Klin, K., Lehner, M., Skorzewska, A., Turzynska, D., Sobolewska, A., Plaznik, A., and Widy-Tyszkiewicz, E. The influence of the long-term administration of Curcuma longa extract on learning and spatial memory as well as the concentration of brain neurotransmitters and level of plasma corticosterone in aged rats. Pharmacol Biochem.Behav. 2010;95:351-358. View abstract.
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  473. Antony, B., Merina, B., Iyer, V. S., Judy, N., Lennertz, K., and Joyal, S. A Pilot Cross-Over Study to Evaluate Human Oral Bioavailability of BCM-95CG (Biocurcumax), A Novel Bioenhanced Preparation of Curcumin. Indian J Pharm Sci. 2008;70:445-449.View abstract.
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  475. Singh, R., Singh, N., Saini, B. S., and Rao, H. S. In vitro antioxidant activity of pet ether extract of black pepper. Indian J Pharmacol 2008;40:147-151. View abstract.
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  477. Giommarelli, C., Zuco, V., Favini, E., Pisano, C., Dal Piaz, F., De Tommasi, N., and Zunino, F. The enhancement of antiproliferative and proapoptotic activity of HDAC inhibitors by curcumin is mediated by Hsp90 inhibition. Cell Mol.Life Sci. 2010;67:995-1004.View abstract.
  478. Yoon, M. J., Kim, E. H., Lim, J. H., Kwon, T. K., and Choi, K. S. Superoxide anion and proteasomal dysfunction contribute to curcumin-induced paraptosis of malignant breast cancer cells. Free Radic.Biol.Med. 3-1-2010;48:713-726. View abstract.
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  494. Sharma, M., Manoharlal, R., Puri, N., and Prasad, R. Antifungal curcumin induces reactive oxygen species and triggers an early apoptosis but prevents hyphae development by targeting the global repressor TUP1 in Candida albicans. Biosci.Rep. 12-17-2009;View abstract.
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  504. Landvik, N. E., Arlt, V. M., Nagy, E., Solhaug, A., Tekpli, X., Schmeiser, H. H., Refsnes, M., Phillips, D. H., Lagadic-Gossmann, D., and Holme, J. A. 3-Nitrobenzanthrone and 3-aminobenzanthrone induce DNA damage and cell signalling in Hepa1c1c7 cells. Mutat.Res 2-3-2010;684(1-2):11-23. View abstract.
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  508. Bhatt, K. H., Pandey, R. K., Dahiya, Y., and Sodhi, A. Protein kinase Cdelta and protein tyrosine kinase regulate peptidoglycan-induced nuclear factor-kappaB activation and inducible nitric oxide synthase expression in mouse peritoneal macrophages in vitro. Mol.Immunol. 2010;47:861-870. View abstract.
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  519. Kamat, A. M., Tharakan, S. T., Sung, B., and Aggarwal, B. B. Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors. Cancer Res 12-1-2009;69:8958-8966. View abstract.
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  522. Bayet-Robert, M., Kwiatkowski, F., Leheurteur, M., Gachon, F., Planchat, E., Abrial, C., Mouret-Reynier, M. A., Durando, X., Barthomeuf, C., and Chollet, P. Phase I dose escalation trial of docetaxel plus curcumin in patients with advanced and metastatic breast cancer. Cancer Biol.Ther. 2010;9:8-14. View abstract.
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  525. Hamaguchi, T., Ono, K., Murase, A., and Yamada, M. Phenolic compounds prevent Alzheimer's pathology through different effects on the amyloid-beta aggregation pathway. Am.J Pathol. 2009;175:2557-2565. View abstract.
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  527. Cartiera, M. S., Ferreira, E. C., Caputo, C., Egan, M. E., Caplan, M. J., and Saltzman, W. M. Partial correction of cystic fibrosis defects with PLGA nanoparticles encapsulating curcumin. Mol.Pharm 2-1-2010;7:86-93. View abstract.
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  536. Mukerjee, A. and Vishwanatha, J. K. Formulation, characterization and evaluation of curcumin-loaded PLGA nanospheres for cancer therapy. Anticancer Res 2009;29:3867-3875. View abstract.
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  539. Henrotin, Y., Clutterbuck, A. L., Allaway, D., Lodwig, E. M., Harris, P., Mathy-Hartert, M., Shakibaei, M., and Mobasheri, A. Biological actions of curcumin on articular chondrocytes. Osteoarthritis.Cartilage. 2010;18:141-149. View abstract.
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  545. Yodkeeree, S., Ampasavate, C., Sung, B., Aggarwal, B. B., and Limtrakul, P. Demethoxycurcumin suppresses migration and invasion of MDA-MB-231 human breast cancer cell line. Eur.J Pharmacol 2-10-2010;627(1-3):8-15. View abstract.
  546. Somers-Edgar, T. J., Taurin, S., Larsen, L., Chandramouli, A., Nelson, M. A., and Rosengren, R. J. Mechanisms for the activity of heterocyclic cyclohexanone curcumin derivatives in estrogen receptor negative human breast cancer cell lines. Invest New Drugs 10-9-2009; View abstract.
  547. Rivera-Espinoza, Y. and Muriel, P. Pharmacological actions of curcumin in liver diseases or damage. Liver Int. 2009;29:1457-1466. View abstract.
  548. Gupta, Y. K., Briyal, S., and Sharma, M. Protective effect of curcumin against kainic acid induced seizures and oxidative stress in rats. Indian J Physiol Pharmacol 2009;53:39-46. View abstract.
  549. Rowe, D. L., Ozbay, T., O'Regan, R. M., and Nahta, R. Modulation of the BRCA1 protein and induction of apoptosis in triple negative breast cancer cell lines by the polyphenolic compound curcumin. Breast Cancer 9-2-2009;3:61-75. View abstract.
  550. Kang, Q. and Chen, A. Curcumin inhibits srebp-2 expression in activated hepatic stellate cells in vitro by reducing the activity of specificity protein-1. Endocrinology 2009;150:5384-5394. View abstract.
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  553. Shen, L. and Ji, H. F. Insights into the inhibition of xanthine oxidase by curcumin. Bioorg.Med.Chem.Lett. 11-1-2009;19:5990-5993. View abstract.
  554. Moghaddam, S. J., Barta, P., Mirabolfathinejad, S. G., Ammar-Aouchiche, Z., Garza, N. T., Vo, T. T., Newman, R. A., Aggarwal, B. B., Evans, C. M., Tuvim, M. J., Lotan, R., and Dickey, B. F. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis 2009;30:1949-1956. View abstract.
  555. Reddy, B. V., Sivagama, Sundari J., Balamurugan, E., and Menon, V. P. Antihyperlipidemic effect of bis-1,7-(2-hydroxyphenyl)-hepta-1,6-diene-3,5-dione, a curcumin analog, on nicotine and streptozotocin treated rats. Mol.Cell Biochem. 2010;335(1-2):249-254. View abstract.
  556. Agrawal, S. S. and Ittiyavirah, S. P. Role of cytokines in anti-implantation activity of H2 receptor blockers in albino Wistar rats. Immunopharmacol.Immunotoxicol. 2010;32:92-98. View abstract.
  557. Tang, Y. H., Bao, M. W., Yang, B., Zhang, Y., Zhang, B. S., Zhou, Q., Chen, J. L., and Huang, C. X. [Curcumin attenuates left ventricular dysfunction and remodeling in rabbits with chronic heart failure.]. Zhonghua Xin.Xue.Guan.Bing.Za Zhi. 2009;37:262-267. View abstract.
  558. Wang, L., Shen, Y., Song, R., Sun, Y., Xu, J., and Xu, Q. An anticancer effect of curcumin mediated by down-regulating phosphatase of regenerating liver-3 expression on highly metastatic melanoma cells. Mol.Pharmacol 2009;76:1238-1245. View abstract.
  559. Shin, H. K., Kim, J., Lee, E. J., and Kim, S. H. Inhibitory effect of curcumin on motility of human oral squamous carcinoma YD-10B cells via suppression of ERK and NF-kappaB activations. Phytother.Res 2010;24:577-582. View abstract.
  560. Wang, Y., Lu, Z., Wu, H., and Lv, F. Study on the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int.J Food Microbiol. 11-30-2009;136:71-74. View abstract.
  561. Zhao, J., Yu, S., Zheng, W., Feng, G., Luo, G., Wang, L., and Zhao, Y. Curcumin improves outcomes and attenuates focal cerebral ischemic injury via antiapoptotic mechanisms in rats. Neurochem.Res 2010;35:374-379. View abstract.
  562. Zhao, Z. D. and Huang, Z. S. [Study on effects of curcumin on expressions of PDGF-BB, PDGFRbeta and ERK1 of HSC]. Zhong.Yao Cai. 2009;32:732-735. View abstract.
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  564. Lim, J. H. and Kwon, T. K. Curcumin inhibits phorbol myristate acetate (PMA)-induced MCP-1 expression by inhibiting ERK and NF-kappaB transcriptional activity. Food Chem.Toxicol 2010;48:47-52. View abstract.
  565. Reeta, K. H., Mehla, J., and Gupta, Y. K. Curcumin is protective against phenytoin-induced cognitive impairment and oxidative stress in rats. Brain Res 12-8-2009;1301:52-60. View abstract.
  566. Cheng, T. C., Lin, C. S., Hsu, C. C., Chen, L. J., Cheng, K. C., and Cheng, J. T. Activation of muscarinic M-1 cholinoceptors by curcumin to increase glucose uptake into skeletal muscle isolated from Wistar rats. Neurosci.Lett. 11-20-2009;465:238-241.View abstract.
  567. Schrenk, D. Dietary fiber, low-molecular-weight food constituents and colo-rectal inflammation in animal models -- a review. Mol.Nutr.Food Res 2009;53:1281-1288. View abstract.
  568. Mun, S. H., Kim, H. S., Kim, J. W., Ko, N. Y., Kim, do K., Lee, B. Y., Kim, B., Won, H. S., Shin, H. S., Han, J. W., Lee, H. Y., Kim, Y. M., and Choi, W. S. Oral administration of curcumin suppresses production of matrix metalloproteinase (MMP)-1 and MMP-3 to ameliorate collagen-induced arthritis: inhibition of the PKCdelta/JNK/c-Jun pathway. J Pharmacol Sci. 2009;111:13-21. View abstract.
  569. Hushmendy, S., Jayakumar, L., Hahn, A. B., Bhoiwala, D., Bhoiwala, D. L., and Crawford, D. R. Select phytochemicals suppress human T-lymphocytes and mouse splenocytes suggesting their use in autoimmunity and transplantation. Nutr.Res 2009;29:568-578. View abstract.
  570. Patel, S. S., Shah, R. S., and Goyal, R. K. Antihyperglycemic, antihyperlipidemic and antioxidant effects of Dihar, a polyherbal ayurvedic formulation in streptozotocin induced diabetic rats. Indian J Exp.Biol. 2009;47:564-570. View abstract.
  571. Takahashi, M., Uechi, S., Takara, K., Asikin, Y., and Wada, K. Evaluation of an oral carrier system in rats: bioavailability and antioxidant properties of liposome-encapsulated curcumin. J Agric.Food Chem. 10-14-2009;57:9141-9146. View abstract.
  572. Xiao, H., Xiao, Q., Zhang, K., Zuo, X., and Shrestha, U. K. Reversal of multidrug resistance by curcumin through FA/BRCA pathway in multiple myeloma cell line MOLP-2/R. Ann.Hematol. 2010;89:399-404. View abstract.
  573. Pinlaor, S., Yongvanit, P., Prakobwong, S., Kaewsamut, B., Khoontawad, J., Pinlaor, P., and Hiraku, Y. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol.Nutr.Food Res 2009;53:1316-1328. View abstract.
  574. Lee, J. H. and Chung, I. K. Curcumin inhibits nuclear localization of telomerase by dissociating the Hsp90 co-chaperone p23 from hTERT. Cancer Lett. 4-1-2010;290:76-86. View abstract.
  575. Nardo, L., Andreoni, A., Bondani, M., Masson, M., and Hjorth, Tonnesen H. Studies on curcumin and curcuminoids. XXXIV. Photophysical properties of a symmetrical, non-substituted curcumin analogue. J Photochem.Photobiol.B 11-9-2009;97:77-86.View abstract.
  576. Hong, D., Zeng, X., Xu, W., Ma, J., Tong, Y., and Chen, Y. Altered profiles of gene expression in curcumin-treated rats with experimentally induced myocardial infarction. Pharmacol Res 2010;61:142-148. View abstract.
  577. Bernard, K., Wang, W., Narlawar, R., Schmidt, B., and Kirk, K. L. Curcumin cross-links cystic fibrosis transmembrane conductance regulator (CFTR) polypeptides and potentiates CFTR channel activity by distinct mechanisms. J Biol.Chem. 11-6-2009;284:30754-30765. View abstract.
  578. Golombick, T., Diamond, T. H., Badmaev, V., Manoharan, A., and Ramakrishna, R. The potential role of curcumin in patients with monoclonal gammopathy of undefined significance--its effect on paraproteinemia and the urinary N-telopeptide of type I collagen bone turnover marker. Clin Cancer Res 9-15-2009;15:5917-5922. View abstract.
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  580. Kang, Q. and Chen, A. Curcumin eliminates oxidized LDL roles in activating hepatic stellate cells by suppressing gene expression of lectin-like oxidized LDL receptor-1. Lab Invest 2009;89:1275-1290. View abstract.
  581. Sandur, S. K., Deorukhkar, A., Pandey, M. K., Pabon, A. M., Shentu, S., Guha, S., Aggarwal, B. B., and Krishnan, S. Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity. Int.J Radiat.Oncol.Biol.Phys. 10-1-2009;75:534-542. View abstract.
  582. Anand, P., Nair, H. B., Sung, B., Kunnumakkara, A. B., Yadav, V. R., Tekmal, R. R., and Aggarwal, B. B. Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo. Biochem.Pharmacol 2-1-2010;79:330-338. View abstract.
  583. Leow, P. C., Tian, Q., Ong, Z. Y., Yang, Z., and Ee, P. L. Antitumor activity of natural compounds, curcumin and PKF118-310, as Wnt/beta-catenin antagonists against human osteosarcoma cells. Invest New Drugs 9-3-2009; View abstract.
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  585. Seugnet, L., Galvin, J. E., Suzuki, Y., Gottschalk, L., and Shaw, P. J. Persistent short-term memory defects following sleep deprivation in a drosophila model of Parkinson disease. Sleep 8-1-2009;32:984-992. View abstract.
  586. Bill, M. A., Bakan, C., Benson, D. M., Jr., Fuchs, J., Young, G., and Lesinski, G. B. Curcumin induces proapoptotic effects against human melanoma cells and modulates the cellular response to immunotherapeutic cytokines. Mol.Cancer Ther. 2009;8:2726-2735. View abstract.
  587. Lee, Y. K., Park, S. Y., Kim, Y. M., and Park, O. J. Regulatory effect of the AMPK-COX-2 signaling pathway in curcumin-induced apoptosis in HT-29 colon cancer cells. Ann.N.Y Acad.Sci. 2009;1171:489-494. View abstract.
  588. Reuter, S., Charlet, J., Juncker, T., Teiten, M. H., Dicato, M., and Diederich, M. Effect of curcumin on nuclear factor kappaB signaling pathways in human chronic myelogenous K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:436-447. View abstract.
  589. Clutterbuck, A. L., Mobasheri, A., Shakibaei, M., Allaway, D., and Harris, P. Interleukin-1beta-induced extracellular matrix degradation and glycosaminoglycan release is inhibited by curcumin in an explant model of cartilage inflammation. Ann.N.Y Acad.Sci. 2009;1171:428-435. View abstract.
  590. Teiten, M. H., Eifes, S., Reuter, S., Duvoix, A., Dicato, M., and Diederich, M. Gene expression profiling related to anti-inflammatory properties of curcumin in K562 leukemia cells. Ann.N.Y Acad.Sci. 2009;1171:391-398. View abstract.
  591. Patil, B. S., Jayaprakasha, G. K., Chidambara Murthy, K. N., and Vikram, A. Bioactive compounds: historical perspectives, opportunities, and challenges. J Agric.Food Chem. 9-23-2009;57:8142-8160. View abstract.
  592. Shytle, R. D., Bickford, P. C., Rezai-zadeh, K., Hou, L., Zeng, J., Tan, J., Sanberg, P. R., Sanberg, C. D., Roschek, B., Jr., Fink, R. C., and Alberte, R. S. Optimized turmeric extracts have potent anti-amyloidogenic effects. Curr.Alzheimer Res 2009;6:564-571. View abstract.
  593. Matsunaga, T., Endo, S., Soda, M., Zhao, H. T., El Kabbani, O., Tajima, K., and Hara, A. Potent and selective inhibition of the tumor marker AKR1B10 by bisdemethoxycurcumin: probing the active site of the enzyme with molecular modeling and site-directed mutagenesis. Biochem.Biophys.Res Commun. 11-6-2009;389:128-132. View abstract.
  594. Hie, M., Yamazaki, M., and Tsukamoto, I. Curcumin suppresses increased bone resorption by inhibiting osteoclastogenesis in rats with streptozotocin-induced diabetes. Eur.J Pharmacol 10-25-2009;621(1-3):1-9. View abstract.
  595. Koppolu, B., Rahimi, M., Nattama, S., Wadajkar, A., and Nguyen, K. T. Development of multiple-layer polymeric particles for targeted and controlled drug delivery. Nanomedicine. 2010;6:355-361. View abstract.
  596. Graham, A. Curcumin adds spice to the debate: lipid metabolism in liver disease. Br.J Pharmacol 2009;157:1352-1353. View abstract.
  597. Watson, J. L., Greenshields, A., Hill, R., Hilchie, A., Lee, P. W., Giacomantonio, C. A., and Hoskin, D. W. Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling. Mol.Carcinog. 2010;49:13-24. View abstract.
  598. Koeberle, A., Northoff, H., and Werz, O. Curcumin blocks prostaglandin E2 biosynthesis through direct inhibition of the microsomal prostaglandin E2 synthase-1. Mol.Cancer Ther. 2009;8:2348-2355. View abstract.
  599. Kim, T., Davis, J., Zhang, A. J., He, X., and Mathews, S. T. Curcumin activates AMPK and suppresses gluconeogenic gene expression in hepatoma cells. Biochem.Biophys.Res Commun. 10-16-2009;388:377-382. View abstract.
  600. Johnson, S. M., Gulhati, P., Arrieta, I., Wang, X., Uchida, T., Gao, T., and Evers, B. M. Curcumin inhibits proliferation of colorectal carcinoma by modulating Akt/mTOR signaling. Anticancer Res 2009;29:3185-3190. View abstract.
  601. Ray, B. and Lahiri, D. K. Neuroinflammation in Alzheimer's disease: different molecular targets and potential therapeutic agents including curcumin. Curr.Opin.Pharmacol 2009;9:434-444. View abstract.
  602. Girish, C., Koner, B. C., Jayanthi, S., Ramachandra, Rao K., Rajesh, B., and Pradhan, S. C. Hepatoprotective activity of picroliv, curcumin and ellagic acid compared to silymarin on paracetamol induced liver toxicity in mice. Fundam.Clin Pharmacol 2009;23:735-745. View abstract.
  603. Khafif, A., Lev-Ari, S., Vexler, A., Barnea, I., Starr, A., Karaush, V., Haif, S., and Ben Yosef, R. Curcumin: a potential radio-enhancer in head and neck cancer. Laryngoscope 2009;119:2019-2026. View abstract.
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  605. Jackson, L. N. and Evers, B. M. Regulation of proliferation, apoptosis and cell cycle in gastrointestinal disorders. Curr.Opin.Pharmacol 2009;9:708-714. View abstract.
  606. Seo, J. H., Jeong, K. J., Oh, W. J., Sul, H. J., Sohn, J. S., Kim, Y. K., Cho, do Y., Kang, J. K., Park, C. G., and Lee, H. Y. Lysophosphatidic acid induces STAT3 phosphorylation and ovarian cancer cell motility: their inhibition by curcumin. Cancer Lett. 2-1-2010;288:50-56. View abstract.
  607. Narala, V. R., Smith, M. R., Adapala, R. K., Ranga, R., Panati, K., Moore, B. B., Leff, T., Reddy, V. D., Kondapi, A. K., and Reddy, R. C. Curcumin is not a ligand for peroxisome proliferator-activated receptor-gamma. Gene Ther.Mol.Biol. 4-1-2009;13:20-25. View abstract.
  608. Boonjaraspinyo, S., Boonmars, T., Aromdee, C., Srisawangwong, T., Kaewsamut, B., Pinlaor, S., Yongvanit, P., and Puapairoj, A. Turmeric reduces inflammatory cells in hamster opisthorchiasis. Parasitol.Res 2009;105:1459-1463. View abstract.
  609. Yadav, R. S., Sankhwar, M. L., Shukla, R. K., Chandra, R., Pant, A. B., Islam, F., and Khanna, V. K. Attenuation of arsenic neurotoxicity by curcumin in rats. Toxicol Appl.Pharmacol 11-1-2009;240:367-376. View abstract.
  610. Qin, X. Y., Cheng, Y., Cui, J., Zhang, Y., and Yu, L. C. Potential protection of curcumin against amyloid beta-induced toxicity on cultured rat prefrontal cortical neurons. Neurosci.Lett. 10-2-2009;463:158-161. View abstract.
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  612. Hegge, A. B., Masson, M., Kristensen, S., and Tonnesen, H. H. Investigation of curcumin-cyclodextrin inclusion complexation in aqueous solutions containing various alcoholic co-solvents and alginates using an UV-VIS titration method. Studies of curcumin and curcuminoides, XXXV. Pharmazie 2009;64:382-389. View abstract.
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  614. Harikrishnan, R., Balasundaram, C., Kim, M. C., Kim, J. S., Han, Y. J., and Heo, M. S. Innate immune response and disease resistance in Carassius auratus by triherbal solvent extracts. Fish.Shellfish.Immunol. 2009;27:508-515. View abstract.
  615. Das, R. K., Kasoju, N., and Bora, U. Encapsulation of curcumin in alginate-chitosan-pluronic composite nanoparticles for delivery to cancer cells. Nanomedicine. 2010;6:153-160. View abstract.
  616. Kumar, A., Dogra, S., and Prakash, A. Protective effect of curcumin (Curcuma longa), against aluminium toxicity: Possible behavioral and biochemical alterations in rats. Behav.Brain Res 12-28-2009;205:384-390. View abstract.
  617. Ahmed, T., Tripathi, A. K., Suke, S. G., Kumar, V., Ahmed, R. S., Das, S., and Banerjee, B. D. Role of HSP27 and reduced glutathione in modulating malathion-induced apoptosis of human peripheral blood mononuclear cells: ameliorating effect of N-acetylcysteine and curcumin. Toxicol In Vitro 2009;23:1319-1325. View abstract.
  618. Samuhasaneeto, S., Thong-Ngam, D., Kulaputana, O., Suyasunanont, D., and Klaikeaw, N. Curcumin decreased oxidative stress, inhibited NF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. J Biomed.Biotechnol. 2009;2009:981963. View abstract.
  619. Ma, Q. L., Yang, F., Rosario, E. R., Ubeda, O. J., Beech, W., Gant, D. J., Chen, P. P., Hudspeth, B., Chen, C., Zhao, Y., Vinters, H. V., Frautschy, S. A., and Cole, G. M. Beta-amyloid oligomers induce phosphorylation of tau and inactivation of insulin receptor substrate via c-Jun N-terminal kinase signaling: suppression by omega-3 fatty acids and curcumin. J Neurosci. 7-15-2009;29:9078-9089. View abstract.
  620. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2009;119:2113. View abstract.
  621. Kang, Q. and Chen, A. Curcumin suppresses expression of low-density lipoprotein (LDL) receptor, leading to the inhibition of LDL-induced activation of hepatic stellate cells. Br.J Pharmacol 2009;157:1354-1367. View abstract.
  622. Jurenka, J. S. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern.Med.Rev. 2009;14:141-153. View abstract.
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  624. Mei, X., Luo, X., Xu, S., Xu, D., Zheng, Y., Xu, S., and Lv, J. Gastroprotective effects of a new zinc(II)-curcumin complex against pylorus-ligature-induced gastric ulcer in rats. Chem.Biol.Interact. 10-30-2009;181:316-321. View abstract.
  625. Kurien, B. T. and Scofield, R. H. Curry spice curcumin and prostate cancer. Mol.Nutr.Food Res 2009;53:939-940. View abstract.
  626. Mathy-Hartert, M., Jacquemond-Collet, I., Priem, F., Sanchez, C., Lambert, C., and Henrotin, Y. Curcumin inhibits pro-inflammatory mediators and metalloproteinase-3 production by chondrocytes. Inflamm.Res 2009;58:899-908. View abstract.
  627. Sumiyoshi, M. and Kimura, Y. Effects of a turmeric extract (Curcuma longa) on chronic ultraviolet B irradiation-induced skin damage in melanin-possessing hairless mice. Phytomedicine. 2009;16:1137-1143. View abstract.
  628. An, J. B., Ma, J. X., Liu, D. Y., Gao, Y. J., Sheng, M. Y., Wang, H. X., and Liu, L. Y. [The effect of curcumin on DNA content, mitochondrial transmembrane potential and calcium of rabbit cultured retinal pigment epithelial cells]. Zhonghua Yan.Ke.Za Zhi. 2009;45:210-215. View abstract.
  629. Prasad, C. P., Rath, G., Mathur, S., Bhatnagar, D., and Ralhan, R. Potent growth suppressive activity of curcumin in human breast cancer cells: Modulation of Wnt/beta-catenin signaling. Chem.Biol.Interact. 10-7-2009;181:263-271. View abstract.
  630. Li, W., Wang, S., Feng, J., Xiao, Y., Xue, X., Zhang, H., Wang, Y., and Liang, X. Structure elucidation and NMR assignments for curcuminoids from the rhizomes of Curcuma longa. Magn Reson.Chem. 2009;47:902-908. View abstract.
  631. DU, P., Li, X., Lin, H. J., Peng, W. F., Liu, J. Y., Ma, Y., Fan, W., and Wang, X. Curcumin inhibits amygdaloid kindled seizures in rats. Chin Med.J (Engl) 6-20-2009;122:1435-1438. View abstract.
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  633. Cheng, D. Q., Wo, X. D., Pan, P. L., Yu, S. B., and Xu, B. H. [Study of the property of lipids reducing of curcumin on hyperlipidemia mice after fermented by Monascus purureus]. Zhong.Yao Cai. 2009;32:388-391. View abstract.
  634. Xiao, H., Zhang, K. J., and Zuo, X. L. [Reversal of multidrug resistance of the drug resistant human multiple myeloma cell line MOLP-2/R by curcumin and its relation with FA/BRCA pathway]. Zhonghua Xue.Ye.Xue.Za Zhi. 2009;30:33-37. View abstract.
  635. Srinivasan, L., Mathew, N., and Muthuswamy, K. In vitro antifilarial activity of glutathione S-transferase inhibitors. Parasitol.Res 2009;105:1179-1182. View abstract.
  636. Sarkar, N., Singh, A. N., and Dubey, V. K. Effect of curcumin on amyloidogenic property of molten globule-like intermediate state of 2,5-diketo-D-gluconate reductase A. Biol.Chem. 2009;390:1057-1061. View abstract.
  637. Shahiduzzaman, M., Dyachenko, V., Khalafalla, R. E., Desouky, A. Y., and Daugschies, A. Effects of curcumin on Cryptosporidium parvum in vitro. Parasitol.Res 2009;105:1155-1161. View abstract.
  638. Shu, J. C., He, Y. J., Lv, X., Ye, G. R., and Wang, L. X. Curcumin prevents liver fibrosis by inducing apoptosis and suppressing activation of hepatic stellate cells. J Nat.Med. 2009;63:415-420. View abstract.
  639. Mahfouz, M. M., Zhou, S. Q., and Kummerow, F. A. Curcumin prevents the oxidation and lipid modification of LDL and its inhibition of prostacyclin generation by endothelial cells in culture. Prostaglandins Other Lipid Mediat. 2009;90(1-2):13-20. View abstract.
  640. Pan, C. J., Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation and in vitro release profiles of drug-eluting controlled biodegradable polymer coating stents. Colloids Surf.B Biointerfaces. 10-15-2009;73:199-206. View abstract.
  641. Xu, Y., Lin, D., Li, S., Li, G., Shyamala, S. G., Barish, P. A., Vernon, M. M., Pan, J., and Ogle, W. O. Curcumin reverses impaired cognition and neuronal plasticity induced by chronic stress. Neuropharmacology 2009;57:463-471. View abstract.
  642. Sompamit, K., Kukongviriyapan, U., Nakmareong, S., Pannangpetch, P., and Kukongviriyapan, V. Curcumin improves vascular function and alleviates oxidative stress in non-lethal lipopolysaccharide-induced endotoxaemia in mice. Eur.J Pharmacol 8-15-2009;616(1-3):192-199. View abstract.
  643. Ramirez-Tortosa, M. C., Ramirez-Tortosa, C. L., Mesa, M. D., Granados, S., Gil, A., and Quiles, J. L. Curcumin ameliorates rabbits's steatohepatitis via respiratory chain, oxidative stress, and TNF-alpha. Free Radic.Biol.Med. 10-1-2009;47:924-931. View abstract.
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  645. Katz, P. S., Trask, A. J., and Lucchesi, P. A. Curcuminoids: Spicing up sympathovagal tone. Nutrition 2009;25(7-8):879-880. View abstract.
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  667. Seehofer, D., Schirmeier, A., Bengmark, S., Carter, J., Koch, M., Glanemann, M., Nussler, A. K., Neuhaus, P., and Menger, M. D. Inhibitory effect of curcumin on early liver regeneration following partial hepatectomy in rats. J Surg.Res 2009;155:195-200. View abstract.
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  673. Merrell, J. G., McLaughlin, S. W., Tie, L., Laurencin, C. T., Chen, A. F., and Nair, L. S. Curcumin-loaded poly(epsilon-caprolactone) nanofibres: diabetic wound dressing with anti-oxidant and anti-inflammatory properties. Clin Exp.Pharmacol Physiol 2009;36:1149-1156. View abstract.
  674. Sharma, M., Manoharlal, R., Shukla, S., Puri, N., Prasad, T., Ambudkar, S. V., and Prasad, R. Curcumin modulates efflux mediated by yeast ABC multidrug transporters and is synergistic with antifungals. Antimicrob.Agents Chemother. 2009;53:3256-3265. View abstract.
  675. Jang, J. Y., Lee, J. H., Jeong, S. Y., Chung, K. T., Choi, Y. H., and Choi, B. T. Partially purified Curcuma longa inhibits alpha-melanocyte-stimulating hormone-stimulated melanogenesis through extracellular signal-regulated kinase or Akt activation-mediated signalling in B16F10 cells. Exp.Dermatol. 2009;18:689-694. View abstract.
  676. Wang, J., Du, X. X., Jiang, H., and Xie, J. X. Curcumin attenuates 6-hydroxydopamine-induced cytotoxicity by anti-oxidation and nuclear factor-kappa B modulation in MES23.5 cells. Biochem.Pharmacol 7-15-2009;78:178-183. View abstract.
  677. Wang, S. L., Li, Y., Wen, Y., Chen, Y. F., Na, L. X., Li, S. T., and Sun, C. H. Curcumin, a potential inhibitor of up-regulation of TNF-alpha and IL-6 induced by palmitate in 3T3-L1 adipocytes through NF-kappaB and JNK pathway. Biomed.Environ.Sci. 2009;22:32-39. View abstract.
  678. Deng, Y. T., Chen, H. M., Cheng, S. J., Chiang, C. P., and Kuo, M. Y. Arecoline-stimulated connective tissue growth factor production in human buccal mucosal fibroblasts: Modulation by curcumin. Oral Oncol. 2009;45:e99-e105. View abstract.
  679. Shin, H. W., Park, S. Y., Lee, K. B., and Jang, J. J. Down-regulation of Wnt signaling during apoptosis of human hepatic stellate cells. Hepatogastroenterology 2009;56:208-212. View abstract.
  680. Cai, X. Z., Wang, J., Li, X. D., Wang, G. L., Liu, F. N., Cheng, M. S., and Li, F. Curcumin suppresses proliferation and invasion in human gastric cancer cells by downregulation of PAK1 activity and cyclin D1 expression. Cancer Biol.Ther. 2009;8:1360-1368.View abstract.
  681. Yu, Y. M. and Lin, H. C. Curcumin prevents human aortic smooth muscle cells migration by inhibiting of MMP-9 expression. Nutr.Metab Cardiovasc.Dis. 2010;20:125-132. View abstract.
  682. Yang, C., Zhang, X., Fan, H., and Liu, Y. Curcumin upregulates transcription factor Nrf2, HO-1 expression and protects rat brains against focal ischemia. Brain Res 7-28-2009;1282:133-141. View abstract.
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  684. Mishra, R. K. and Singh, S. K. Reversible antifertility effect of aqueous rhizome extract of Curcuma longa L. in male laboratory mice. Contraception 2009;79:479-487. View abstract.
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  686. Masoumi, A., Goldenson, B., Ghirmai, S., Avagyan, H., Zaghi, J., Abel, K., Zheng, X., Espinosa-Jeffrey, A., Mahanian, M., Liu, P. T., Hewison, M., Mizwickie, M., Cashman, J., and Fiala, M. 1alpha,25-dihydroxyvitamin D3 interacts with curcuminoids to stimulate amyloid-beta clearance by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2009;17:703-717. View abstract.
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  696. Mendonca, L. M., Dos Santos, G. C., Antonucci, G. A., Dos Santos, A. C., Bianchi, Mde L., and Antunes, L. M. Evaluation of the cytotoxicity and genotoxicity of curcumin in PC12 cells. Mutat.Res 4-30-2009;675(1-2):29-34. View abstract.
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  700. Jancinova, V., Perecko, T., Nosal, R., Kostalova, D., Bauerova, K., and Drabikova, K. Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition. Eur.J Pharmacol 6-10-2009;612(1-3):161-166.View abstract.
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  703. Hegde, M. L., Bharathi, P., Suram, A., Venugopal, C., Jagannathan, R., Poddar, P., Srinivas, P., Sambamurti, K., Rao, K. J., Scancar, J., Messori, L., Zecca, L., and Zatta, P. Challenges associated with metal chelation therapy in Alzheimer's disease. J Alzheimers.Dis. 2009;17:457-468. View abstract.
  704. Dance-Barnes, S. T., Kock, N. D., Moore, J. E., Lin, E. Y., Mosley, L. J., D'Agostino, R. B., Jr., McCoy, T. P., Townsend, A. J., and Miller, M. S. Lung tumor promotion by curcumin. Carcinogenesis 2009;30:1016-1023. View abstract.
  705. Herebian, D., Choi, J. H., Abd El-Aty, A. M., Shim, J. H., and Spiteller, M. Metabolite analysis in Curcuma domestica using various GC-MS and LC-MS separation and detection techniques. Biomed.Chromatogr. 2009;23:951-965. View abstract.
  706. Sanderson, R. O., Beata, C., Flipo, R. M., Genevois, J. P., Macias, C., Tacke, S., Vezzoni, A., and Innes, J. F. Systematic review of the management of canine osteoarthritis. Vet.Rec. 4-4-2009;164:418-424. View abstract.
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  710. Chaturvedi, T. P. Uses of turmeric in dentistry: an update. Indian J Dent.Res 2009;20:107-109. View abstract.
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  714. Avagyan, H., Goldenson, B., Tse, E., Masoumi, A., Porter, V., Wiedau-Pazos, M., Sayre, J., Ong, R., Mahanian, M., Koo, P., Bae, S., Micic, M., Liu, P. T., Rosenthal, M. J., and Fiala, M. Immune blood biomarkers of Alzheimer disease patients. J.Neuroimmunol. 5-29-2009;210(1-2):67-72. View abstract.
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  717. Leung, M. H. and Kee, T. W. Effective stabilization of curcumin by association to plasma proteins: human serum albumin and fibrinogen. Langmuir 5-19-2009;25:5773-5777. View abstract.
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  723. Tang, Y., Zheng, S., and Chen, A. Curcumin eliminates leptin's effects on hepatic stellate cell activation via interrupting leptin signaling. Endocrinology 2009;150:3011-3020. View abstract.
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  725. Wang, J. B., Qi, L. L., Zheng, S. D., Wang, H. Z., and Wu, T. X. Curcumin suppresses PPARdelta expression and related genes in HT-29 cells. World J Gastroenterol. 3-21-2009;15:1346-1352. View abstract.
  726. Heo, H. J., Lee, S. Y., Lee, M. N., Lee, H. J., Seok, J. H., and Lee, C. J. Genistein and curcumin suppress epidermal growth factor-induced MUC5AC mucin production and gene expression from human airway epithelial cells. Phytother.Res 2009;23:1458-1461.View abstract.
  727. Chiu, T. L. and Su, C. C. Curcumin inhibits proliferation and migration by increasing the Bax to Bcl-2 ratio and decreasing NF-kappaBp65 expression in breast cancer MDA-MB-231 cells. Int.J Mol.Med. 2009;23:469-475. View abstract.
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  732. Rezende, L. F., Vieira, A. S., Negro, A., Langone, F., and Boschero, A. C. Ciliary neurotrophic factor (CNTF) signals through STAT3-SOCS3 pathway and protects rat pancreatic islets from cytokine-induced apoptosis. Cytokine 2009;46:65-71. View abstract.
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  735. Chen, Q., Lu, G., Wang, Y., Xu, Y., Zheng, Y., Yan, L., Jiang, Z., Yang, L., Zhan, J., Wu, Y., and Zhou, J. Cytoskeleton disorganization during apoptosis induced by curcumin in A549 lung adenocarcinoma cells. Planta Med. 2009;75:808-813. View abstract.
  736. Capini, C., Jaturanpinyo, M., Chang, H. I., Mutalik, S., McNally, A., Street, S., Steptoe, R., O'Sullivan, B., Davies, N., and Thomas, R. Antigen-specific suppression of inflammatory arthritis using liposomes. J Immunol. 3-15-2009;182:3556-3565. View abstract.
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  749. Yadav, V. R., Suresh, S., Devi, K., and Yadav, S. Novel formulation of solid lipid microparticles of curcumin for anti-angiogenic and anti-inflammatory activity for optimization of therapy of inflammatory bowel disease. J Pharm Pharmacol 2009;61:311-321. View abstract.
  750. Cohen, A. N., Veena, M. S., Srivatsan, E. S., and Wang, M. B. Suppression of interleukin 6 and 8 production in head and neck cancer cells with curcumin via inhibition of Ikappa beta kinase. Arch.Otolaryngol.Head Neck Surg. 2009;135:190-197. View abstract.
  751. Mishra, K., Dash, A. P., Swain, B. K., and Dey, N. Anti-malarial activities of Andrographis paniculata and Hedyotis corymbosa extracts and their combination with curcumin. Malar.J 2009;8:26. View abstract.
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  753. Al Zanbagi, N. A. and Zelai, N. T. Two methods for attenuating Toxoplasma gondii tachyzoites RH strain by using ethanol extract of Curcuma longa. J Egypt Soc.Parasitol. 2008;38:965-976. View abstract.
  754. De, R., Kundu, P., Swarnakar, S., Ramamurthy, T., Chowdhury, A., Nair, G. B., and Mukhopadhyay, A. K. Antimicrobial activity of curcumin against Helicobacter pylori isolates from India and during infections in mice. Antimicrob.Agents Chemother. 2009;53:1592-1597. View abstract.
  755. Kim, Y., Lee, J. H., Ryu, J., and Kim, D. J. Multivalent & multifunctional ligands to beta-amyloid. Curr.Pharm Des 2009;15:637-658.View abstract.
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  759. Sun, A. Y., Wang, Q., Simonyi, A., and Sun, G. Y. Botanical phenolics and brain health. Neuromolecular.Med. 2008;10:259-274.View abstract.
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  761. Mahattanadul, S., Nakamura, T., Panichayupakaranant, P., Phdoongsombut, N., Tungsinmunkong, K., and Bouking, P. Comparative antiulcer effect of bisdemethoxycurcumin and curcumin in a gastric ulcer model system. Phytomedicine. 2009;16:342-351. View abstract.
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  763. Braumann, C., Guenther, N., Loeffler, L. M., and Dubiel, W. Liver metastases after colonic carcinoma--palliative chemotherapy plus curcumin. Int.J Colorectal Dis. 2009;24:859-860. View abstract.
  764. Lavoie, S., Chen, Y., Dalton, T. P., Gysin, R., Cuenod, M., Steullet, P., and Do, K. Q. Curcumin, quercetin, and tBHQ modulate glutathione levels in astrocytes and neurons: importance of the glutamate cysteine ligase modifier subunit. J Neurochem. 2009;108:1410-1422. View abstract.
  765. Beevers, C. S., Chen, L., Liu, L., Luo, Y., Webster, N. J., and Huang, S. Curcumin disrupts the Mammalian target of rapamycin-raptor complex. Cancer Res 2-1-2009;69:1000-1008. View abstract.
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  767. Zhou, H., Li, X., and Gao, M. Curcumin protects PC12 cells from corticosterone-induced cytotoxicity: possible involvement of the ERK1/2 pathway. Basic Clin Pharmacol Toxicol 2009;104:236-240. View abstract.
  768. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Supplementation of curcumin and vitamin E enhances oxidative stress, but restores hepatic histoarchitecture in hypothyroid rats. Life Sci. 3-13-2009;84(11-12):372-379. View abstract.
  769. Inoue, K., Nakagawa, A., Hino, T., and Oka, H. Screening assay for metal-catalyzed oxidation inhibitors using liquid chromatography-mass spectrometry with an N-terminal beta-amyloid peptide. Anal.Chem. 3-1-2009;81:1819-1825. View abstract.
  770. Dai, F., Chen, W. F., Zhou, B., Yang, L., and Liu, Z. L. Antioxidative effects of curcumin and its analogues against the free-radical-induced peroxidation of linoleic acid in micelles. Phytother.Res 2009;23:1220-1228. View abstract.
  771. Suzuki, M., Betsuyaku, T., Ito, Y., Nagai, K., Odajima, N., Moriyama, C., Nasuhara, Y., and Nishimura, M. Curcumin attenuates elastase- and cigarette smoke-induced pulmonary emphysema in mice. Am.J Physiol Lung Cell Mol.Physiol 2009;296:L614-L623.View abstract.
  772. Iqbal, M., Okazaki, Y., and Okada, S. Curcumin attenuates oxidative damage in animals treated with a renal carcinogen, ferric nitrilotriacetate (Fe-NTA): implications for cancer prevention. Mol.Cell Biochem. 2009;324(1-2):157-164. View abstract.
  773. Conboy, L., Foley, A. G., O'Boyle, N. M., Lawlor, M., Gallagher, H. C., Murphy, K. J., and Regan, C. M. Curcumin-induced degradation of PKC delta is associated with enhanced dentate NCAM PSA expression and spatial learning in adult and aged Wistar rats. Biochem.Pharmacol 4-1-2009;77:1254-1265. View abstract.
  774. Khalooghi, K., Hashemi, S., Mehraban, N., Amiri, P., Bazzaz, J. T., Larijani, B., and Amoli, M. M. In vitro modulation of TCF7L2 gene expression in human pancreatic cells. Mol.Biol.Rep. 2009;36:2329-2332. View abstract.
  775. Srivastava, G. and Mehta, J. L. Currying the heart: curcumin and cardioprotection. J Cardiovasc.Pharmacol Ther. 2009;14:22-27.View abstract.
  776. Lin, Y. L., Lin, C. Y., Chi, C. W., and Huang, Y. T. Study on antifibrotic effects of curcumin in rat hepatic stellate cells. Phytother.Res 2009;23:927-932. View abstract.
  777. Marczylo, T. H., Steward, W. P., and Gescher, A. J. Rapid analysis of curcumin and curcumin metabolites in rat biomatrices using a novel ultraperformance liquid chromatography (UPLC) method. J Agric.Food Chem. 2-11-2009;57:797-803. View abstract.
  778. Alwi, I., Santoso, T., Suyono, S., Sutrisna, B., Suyatna, F. D., Kresno, S. B., and Ernie, S. The effect of curcumin on lipid level in patients with acute coronary syndrome. Acta Med.Indones. 2008;40:201-210. View abstract.
  779. Kurien, B. T. and Scofield, R. H. Heat-solubilized curcumin should be considered in clinical trials for increasing bioavailability. Clin Cancer Res 1-15-2009;15:747. View abstract.
  780. Shoheib, Z. S., El Nouby, K. A., Deyab, F. A., Dar, Y. D., and Kabbash, A. M. Potential effect of Curcuma longa extract on infectivity and pathogenicity of Schistosoma mansoni cercariae. J Egypt Soc.Parasitol. 2008;38:141-159. View abstract.
  781. Kim, H. I., Huang, H., Cheepala, S., Huang, S., and Chung, J. Curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion. Cancer Prev.Res (Phila Pa) 2008;1:385-391. View abstract.
  782. Li, Q. F., Zheng, Y. B., Yang, H. B., Shi, S. L., Zhao, Z. L., and Chen, J. A. [Changes of nuclear matrix proteins during apoptosis of human osteosarcoma MG-63 cells induced by curcumin]. Fen.Zi.Xi.Bao.Sheng Wu Xue.Bao. 2008;41:473-481. View abstract.
  783. Mandeville, J. S., Froehlich, E., and Tajmir-Riahi, H. A. Study of curcumin and genistein interactions with human serum albumin. J Pharm Biomed.Anal. 2-20-2009;49:468-474. View abstract.
  784. Farinacci, M., Colitti, M., and Stefanon, B. Modulation of ovine neutrophil function and apoptosis by standardized extracts of Echinacea angustifolia, Butea frondosa and Curcuma longa. Vet.Immunol.Immunopathol. 4-15-2009;128:366-373. View abstract.
  785. Balasubramanian, K. Molecular orbital basis for yellow curry spice curcumin's prevention of Alzheimer's disease. J Agric.Food Chem. 5-17-2006;54:3512-3520. View abstract.
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  787. Adaramoye, O. A. and Medeiros, I. A. Involvement of Na(+)-Ca exchanger in the endothelium-independent vasorelaxation induced by Curcuma longa L. in isolated rat superior mesenteric arteries. J Smooth Muscle Res 2008;44:151-158. View abstract.
  788. Mandal, M. N., Patlolla, J. M., Zheng, L., Agbaga, M. P., Tran, J. T., Wicker, L., Kasus-Jacobi, A., Elliott, M. H., Rao, C. V., and Anderson, R. E. Curcumin protects retinal cells from light-and oxidant stress-induced cell death. Free Radic.Biol.Med. 3-1-2009;46:672-679. View abstract.
  789. Cucuzza, L. S., Motta, M., Miretti, S., Accornero, P., and Baratta, M. Curcuminoid-phospholipid complex induces apoptosis in mammary epithelial cells by STAT-3 signaling. Exp.Mol.Med. 12-31-2008;40:647-657. View abstract.
  790. Zhang, K. S., Li, G. C., He, Y. W., Yi, Y. M., Liao, S. L., Wang, Z., and Du, J. [Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells]. Zhong.Yao Cai. 2008;31:1207-1211. View abstract.
  791. Aggarwal, B. B. and Sung, B. Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets. Trends Pharmacol Sci. 2009;30:85-94. View abstract.
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  793. Jyoti, A., Sethi, P., and Sharma, D. Curcumin protects against electrobehavioral progression of seizures in the iron-induced experimental model of epileptogenesis. Epilepsy Behav. 2009;14:300-308. View abstract.
  794. Magalhaes, L. G., Machado, C. B., Morais, E. R., Moreira, E. B., Soares, C. S., da Silva, S. H., Silva Filho, A. A., and Rodrigues, V. In vitro schistosomicidal activity of curcumin against Schistosoma mansoni adult worms. Parasitol.Res 2009;104:1197-1201. View abstract.
  795. Di Giorgio, A. M., Hou, Y., Zhao, X., Zhang, B., Lyeth, B. G., and Russell, M. J. Dimethyl sulfoxide provides neuroprotection in a traumatic brain injury model. Restor.Neurol.Neurosci. 2008;26:501-507. View abstract.
  796. Kwon, Y. and Magnuson, B. A. Age-related differential responses to curcumin-induced apoptosis during the initiation of colon cancer in rats. Food Chem.Toxicol 2009;47:377-385. View abstract.
  797. Lee, Y. K., Lee, W. S., Hwang, J. T., Kwon, D. Y., Surh, Y. J., and Park, O. J. Curcumin exerts antidifferentiation effect through AMPKalpha-PPAR-gamma in 3T3-L1 adipocytes and antiproliferatory effect through AMPKalpha-COX-2 in cancer cells. J Agric.Food Chem. 1-14-2009;57:305-310. View abstract.
  798. Tian, Y. M., Zhou, D., Zhang, W., and Cheng, C. G. [Comparison and correlative analysis of trace elements in five kinds of radix curcumae]. Guang.Pu.Xue.Yu Guang.Pu.Fen.Xi. 2008;28:2192-2195. View abstract.
  799. Cashman, J. R., Ghirmai, S., Abel, K. J., and Fiala, M. Immune defects in Alzheimer's disease: new medications development. BMC.Neurosci. 2008;9 Suppl 2:S13. View abstract.
  800. Chen, Z. Q., Jie, X., and Mo, Z. N. [Curcumin inhibits growth, induces G1 arrest and apoptosis on human prostatic stromal cells by regulating Bcl-2/Bax]. Zhongguo Zhong.Yao Za Zhi. 2008;33:2022-2025. View abstract.
  801. Conney, A. H., Lysz, T., Ferraro, T., Abidi, T. F., Manchand, P. S., Laskin, J. D., and Huang, M. T. Inhibitory effect of curcumin and some related dietary compounds on tumor promotion and arachidonic acid metabolism in mouse skin. Adv.Enzyme Regul. 1991;31:385-396. View abstract.
  802. Li, X., Hu, Y. B., and Peng, J. W. [Silicon dioxide-upregulated plasminogen activators inhibitor-1 protein expression is dependent on activation of extracellular signal-regulated kinase/activator protein-1 signaling pathway]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:387-390. View abstract.
  803. Shapiro, H. and Bruck, R. Therapeutic potential of curcumin in non-alcoholic steatohepatitis. Nutr.Res Rev. 2005;18:212-221.View abstract.
  804. Ono, K., Hirohata, M., and Yamada, M. Alpha-synuclein assembly as a therapeutic target of Parkinson's disease and related disorders. Curr.Pharm Des 2008;14:3247-3266. View abstract.
  805. Rafiee, P., Nelson, V. M., Manley, S., Wellner, M., Floer, M., Binion, D. G., and Shaker, R. Effect of curcumin on acidic pH-induced expression of IL-6 and IL-8 in human esophageal epithelial cells (HET-1A): role of PKC, MAPKs, and NF-kappaB. Am.J Physiol Gastrointest.Liver Physiol 2009;296:G388-G398. View abstract.
  806. Farooqui, T. and Farooqui, A. A. Aging: an important factor for the pathogenesis of neurodegenerative diseases. Mech.Ageing Dev. 2009;130:203-215. View abstract.
  807. Tajik, H., Tamaddonfard, E., and Hamzeh-Gooshchi, N. Interaction between curcumin and opioid system in the formalin test of rats. Pak.J Biol.Sci. 8-1-2007;10:2583-2586. View abstract.
  808. Priya, S. and Sudhakaran, P. R. Curcumin-induced recovery from hepatic injury involves induction of apoptosis of activated hepatic stellate cells. Indian J Biochem.Biophys. 2008;45:317-325. View abstract.
  809. Zhu, R. F., Zhou, M., He, J. L., Ding, F. Y., Yu, S. Q., and Xu, G. L. [Protective effect of curcumin on oleic-induced acute lung injury in rats]. Zhongguo Zhong.Yao Za Zhi. 2008;33:2141-2145. View abstract.
  810. Liu, A. C., Zhao, L. X., Zhai, G. X., Lou, H. X., and Du, J. S. [An investigation on formation mechanisms and preparation of curcumin phospholipid complex]. Zhongguo Zhong.Yao Za Zhi. 2008;33:2112-2117. View abstract.
  811. Chen, Z., Zhu, L., Song, T., Chen, J., and Guo, Z. A novel curcumin assay with the metal ion Cu (II) as a simple probe by resonance light scattering technique. Spectrochim.Acta A Mol.Biomol.Spectrosc. 2009;72:518-522. View abstract.
  812. Madden, K., Flowers, L., Salani, R., Horowitz, I., Logan, S., Kowalski, K., Xie, J., and Mohammed, S. I. Proteomics-based approach to elucidate the mechanism of antitumor effect of curcumin in cervical cancer. Prostaglandins Leukot.Essent.Fatty Acids 2009;80:9-18. View abstract.
  813. Verma, R. J., Chakraborty, B. S., Patel, C., and Mathuria, N. Curcumin ameliorates aflatoxin-induced changes in SDH and ATPase activities in liver and kidney of mice. Acta Pol.Pharm 2008;65:415-419. View abstract.
  814. Girish, C. and Pradhan, S. C. Drug development for liver diseases: focus on picroliv, ellagic acid and curcumin. Fundam.Clin Pharmacol 2008;22:623-632. View abstract.
  815. Martins, C. V., da Silva, D. L., Neres, A. T., Magalhaes, T. F., Watanabe, G. A., Modolo, L. V., Sabino, A. A., de Fatima, A., and de Resende, M. A. Curcumin as a promising antifungal of clinical interest. J Antimicrob.Chemother. 2009;63:337-339. View abstract.
  816. Krasovsky, J., Chang, D. H., Deng, G., Yeung, S., Lee, M., Leung, P. C., Cunningham-Rundles, S., Cassileth, B., and Dhodapkar, M. V. Inhibition of human dendritic cell activation by hydroethanolic but not lipophilic extracts of turmeric (Curcuma longa). Planta Med. 2009;75:312-315. View abstract.
  817. Shimouchi, A., Nose, K., Takaoka, M., Hayashi, H., and Kondo, T. Effect of dietary turmeric on breath hydrogen. Dig.Dis.Sci. 2009;54:1725-1729. View abstract.
  818. Rastogi, M., Ojha, R. P., Rajamanickam, G. V., Agrawal, A., Aggarwal, A., and Dubey, G. P. Curcuminoids modulates oxidative damage and mitochondrial dysfunction in diabetic rat brain. Free Radic.Res 2008;42(11-12):999-1005. View abstract.
  819. Sharma, D., Sethi, P., Hussain, E., and Singh, R. Curcumin counteracts the aluminium-induced ageing-related alterations in oxidative stress, Na+, K+ ATPase and protein kinase C in adult and old rat brain regions. Biogerontology. 2009;10:489-502. View abstract.
  820. Pan, W., Yang, H., Cao, C., Song, X., Wallin, B., Kivlin, R., Lu, S., Hu, G., Di, W., and Wan, Y. AMPK mediates curcumin-induced cell death in CaOV3 ovarian cancer cells. Oncol.Rep. 2008;20:1553-1559. View abstract.
  821. Choi, H., Chun, Y. S., Shin, Y. J., Ye, S. K., Kim, M. S., and Park, J. W. Curcumin attenuates cytochrome P450 induction in response to 2,3,7,8-tetrachlorodibenzo-p-dioxin by ROS-dependently degrading AhR and ARNT. Cancer Sci. 2008;99:2518-2524. View abstract.
  822. Cao, J., Liu, Y., Jia, L., Jiang, L. P., Geng, C. Y., Yao, X. F., Kong, Y., Jiang, B. N., and Zhong, L. F. Curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in HepG2 cells by ROS scavenging. J Agric.Food Chem. 12-24-2008;56:12059-12063. View abstract.
  823. Kozuki, Y., Miura, Y., and Yagasaki, K. Inhibitory effect of curcumin on the invasion of rat ascites hepatoma cells in vitro and ex vivo. Cytotechnology 2001;35:57-63. View abstract.
  824. Guzel, A., Kanter, M., Aksu, B., Basaran, U. N., Yalcin, O., Guzel, A., Uzun, H., Konukoglu, D., and Karasalihoglu, S. Preventive effects of curcumin on different aspiration material-induced lung injury in rats. Pediatr.Surg.Int. 2009;25:83-92. View abstract.
  825. Lubbad, A., Oriowo, M. A., and Khan, I. Curcumin attenuates inflammation through inhibition of TLR-4 receptor in experimental colitis. Mol.Cell Biochem. 2009;322(1-2):127-135. View abstract.
  826. Ryu, M. J., Cho, M., Song, J. Y., Yun, Y. S., Choi, I. W., Kim, D. E., Park, B. S., and Oh, S. Natural derivatives of curcumin attenuate the Wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300. Biochem.Biophys.Res Commun. 12-26-2008;377:1304-1308. View abstract.
  827. Rosello, D. M., Balestrasse, K., Coll, C., Coll, S., Tallis, S., Gurni, A., Tomaro, M. L., Lemberg, A., and Perazzo, J. C. Oxidative stress and hippocampus in a low-grade hepatic encephalopathy model: protective effects of curcumin. Hepatol.Res 2008;38:1148-1153.View abstract.
  828. Cutler, W. B. Re: Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cell. Menopause. 2008;15:1195. View abstract.
  829. Agrawal, D. K., Saikia, D., Tiwari, R., Ojha, S., Shanker, K., Kumar, J. K., Gupta, A. K., Tandon, S., Negi, A. S., and Khanuja, S. P. Demethoxycurcumin and its semisynthetic analogues as antitubercular agents. Planta Med. 2008;74:1828-1831. View abstract.
  830. Huang, M. T., Lysz, T., Ferraro, T., Abidi, T. F., Laskin, J. D., and Conney, A. H. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 2-1-1991;51:813-819. View abstract.
  831. Quitschke, W. W. Differential solubility of curcuminoids in serum and albumin solutions: implications for analytical and therapeutic applications. BMC.Biotechnol. 2008;8:84. View abstract.
  832. Ng, S. C. and Kamm, M. A. Therapeutic strategies for the management of ulcerative colitis. Inflamm.Bowel.Dis. 2009;15:935-950.View abstract.
  833. Jain, S. K., Rains, J., Croad, J., Larson, B., and Jones, K. Curcumin supplementation lowers TNF-alpha, IL-6, IL-8, and MCP-1 secretion in high glucose-treated cultured monocytes and blood levels of TNF-alpha, IL-6, MCP-1, glucose, and glycosylated hemoglobin in diabetic rats. Antioxid.Redox.Signal. 2009;11:241-249. View abstract.
  834. Chang, L. Y., Wan, H. C., Lai, Y. L., Kuo, Y. F., Liu, T. Y., Chen, Y. T., and Hung, S. L. Areca nut extracts increased expression of inflammatory cytokines, tumor necrosis factor-alpha, interleukin-1beta, interleukin-6 and interleukin-8, in peripheral blood mononuclear cells. J Periodontal Res 2009;44:175-183. View abstract.
  835. Liu, Y., Yang, Z., Du, J., Yao, X., Lei, R., Zheng, X., Liu, J., Hu, H., and Li, H. Interaction of curcumin with intravenous immunoglobulin: a fluorescence quenching and Fourier transformation infrared spectroscopy study. Immunobiology 2008;213:651-661. View abstract.
  836. Nanditha, B. and Prabhasankar, P. Antioxidants in bakery products: a review. Crit Rev.Food Sci.Nutr. 2009;49:1-27. View abstract.
  837. Harikrishnan, R. and Balasundaram, C. In vitro and in vivo studies of the use of some medicinal herbals against the pathogen Aeromonas hydrophila in goldfish. J Aquat.Anim Health 2008;20:165-176. View abstract.
  838. Jang, E. M., Choi, M. S., Jung, U. J., Kim, M. J., Kim, H. J., Jeon, S. M., Shin, S. K., Seong, C. N., and Lee, M. K. Beneficial effects of curcumin on hyperlipidemia and insulin resistance in high-fat-fed hamsters. Metabolism 2008;57:1576-1583. View abstract.
  839. Muriel, P. NF-kappaB in liver diseases: a target for drug therapy. J Appl.Toxicol 2009;29:91-100. View abstract.
  840. Ahmed, T. and Gilani, A. H. Inhibitory effect of curcuminoids on acetylcholinesterase activity and attenuation of scopolamine-induced amnesia may explain medicinal use of turmeric in Alzheimer's disease. Pharmacol Biochem.Behav. 2009;91:554-559.View abstract.
  841. Youn, Y. N., Lim, E., Lee, N., Kim, Y. S., Koo, M. S., and Choi, S. Y. Screening of Korean medicinal plants for possible osteoclastogenesis effects in vitro. Genes Nutr. 2008;2:375-380. View abstract.
  842. Chen, D., Nie, M., Fan, M. W., and Bian, Z. Anti-inflammatory activity of curcumin in macrophages stimulated by lipopolysaccharides from Porphyromonas gingivalis. Pharmacology 2008;82:264-269. View abstract.
  843. Shukla, S., Zaher, H., Hartz, A., Bauer, B., Ware, J. A., and Ambudkar, S. V. Curcumin inhibits the activity of ABCG2/BCRP1, a multidrug resistance-linked ABC drug transporter in mice. Pharm Res 2009;26:480-487. View abstract.
  844. Chen, C., Johnston, T. D., Jeon, H., Gedaly, R., McHugh, P. P., Burke, T. G., and Ranjan, D. An in vitro study of liposomal curcumin: stability, toxicity and biological activity in human lymphocytes and Epstein-Barr virus-transformed human B-cells. Int.J Pharm 1-21-2009;366(1-2):133-139. View abstract.
  845. Zhang, L. J., Wu, C. F., Meng, X. L., Yuan, D., Cai, X. D., Wang, Q. L., and Yang, J. Y. Comparison of inhibitory potency of three different curcuminoid pigments on nitric oxide and tumor necrosis factor production of rat primary microglia induced by lipopolysaccharide. Neurosci.Lett. 12-5-2008;447:48-53. View abstract.
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  847. Lubbad, A. S., Oriowo, M. A., and Khan, I. Curcumin reverses attenuated carbachol-induced contraction of the colon in a rat model of colitis. Scand.J Gastroenterol. 2009;44:187-194. View abstract.
  848. Dohare, P., Garg, P., Sharma, U., Jagannathan, N. R., and Ray, M. Neuroprotective efficacy and therapeutic window of curcuma oil: in rat embolic stroke model. BMC.Complement Altern.Med. 2008;8:55. View abstract.
  849. Inoue, K., Nomura, C., Ito, S., Nagatsu, A., Hino, T., and Oka, H. Purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography. J Agric.Food Chem. 10-22-2008;56:9328-9336. View abstract.
  850. Wang, L. Y., Zhang, M., Zhang, C. F., and Wang, Z. T. Alkaloid and sesquiterpenes from the root tuber of Curcuma longa. Yao Xue.Xue.Bao. 2008;43:724-727. View abstract.
  851. Larmonier, C. B., Uno, J. K., Lee, K. M., Karrasch, T., Laubitz, D., Thurston, R., Midura-Kiela, M. T., Ghishan, F. K., Sartor, R. B., Jobin, C., and Kiela, P. R. Limited effects of dietary curcumin on Th-1 driven colitis in IL-10 deficient mice suggest an IL-10-dependent mechanism of protection. Am.J Physiol Gastrointest.Liver Physiol 2008;295:G1079-G1091. View abstract.
  852. Barnes, P. J. Role of HDAC2 in the pathophysiology of COPD. Annu.Rev.Physiol 2009;71:451-464. View abstract.
  853. Tajik, H., Tamaddonfard, E., and Hamzeh-Gooshchi, N. The effect of curcumin (active substance of turmeric) on the acetic acid-induced visceral nociception in rats. Pak.J Biol.Sci. 1-15-2008;11:312-314. View abstract.
  854. Moosajee, M., Gregory-Evans, K., Ellis, C. D., Seabra, M. C., and Gregory-Evans, C. Y. Translational bypass of nonsense mutations in zebrafish rep1, pax2.1 and lamb1 highlights a viable therapeutic option for untreatable genetic eye disease. Hum.Mol.Genet. 12-15-2008;17:3987-4000. View abstract.
  855. Kapoor, P., Ansari, M. N., and Bhandari, U. Modulatory effect of curcumin on methionine-induced hyperlipidemia and hyperhomocysteinemia in albino rats. Indian J Exp.Biol. 2008;46:534-540. View abstract.
  856. Sun, J., Yang, D., Li, S., Xu, Z., Wang, X., and Bai, C. Effects of curcumin or dexamethasone on lung ischaemia-reperfusion injury in rats. Eur.Respir.J 2009;33:398-404. View abstract.
  857. Tharappel, J. C., Lehmler, H. J., Srinivasan, C., Robertson, L. W., Spear, B. T., and Glauert, H. P. Effect of antioxidant phytochemicals on the hepatic tumor promoting activity of 3,3',4,4'-tetrachlorobiphenyl (PCB-77). Food Chem.Toxicol 2008;46:3467-3474. View abstract.
  858. Adapala, N. and Chan, M. M. Long-term use of an antiinflammatory, curcumin, suppressed type 1 immunity and exacerbated visceral leishmaniasis in a chronic experimental model. Lab Invest 2008;88:1329-1339. View abstract.
  859. Chen, H. W., Lee, J. Y., Huang, J. Y., Wang, C. C., Chen, W. J., Su, S. F., Huang, C. W., Ho, C. C., Chen, J. J., Tsai, M. F., Yu, S. L., and Yang, P. C. Curcumin inhibits lung cancer cell invasion and metastasis through the tumor suppressor HLJ1. Cancer Res 9-15-2008;68:7428-7438. View abstract.
  860. Milacic, V., Banerjee, S., Landis-Piwowar, K. R., Sarkar, F. H., Majumdar, A. P., and Dou, Q. P. Curcumin inhibits the proteasome activity in human colon cancer cells in vitro and in vivo. Cancer Res 9-15-2008;68:7283-7292. View abstract.
  861. Ren, L., Wang, J., Tang, J., Pan, C., and Huang, N. [Influence of curcumin--loaded poly (lactide-co-glycolide) films on the proliferation of vascular smooth muscle cells]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:874-878. View abstract.
  862. Yu, S., Shen, G., Khor, T. O., Kim, J. H., and Kong, A. N. Curcumin inhibits Akt/mammalian target of rapamycin signaling through protein phosphatase-dependent mechanism. Mol.Cancer Ther. 2008;7:2609-2620. View abstract.
  863. Sahu, A., Kasoju, N., and Bora, U. Fluorescence study of the curcumin-casein micelle complexation and its application as a drug nanocarrier to cancer cells. Biomacromolecules. 2008;9:2905-2912. View abstract.
  864. Patel, N. A., Patel, N. J., and Patel, R. P. Design and evaluation of transdermal drug delivery system for curcumin as an anti-inflammatory drug. Drug Dev.Ind.Pharm 2009;35:234-242. View abstract.
  865. Kelley, B. J. and Knopman, D. S. Alternative medicine and Alzheimer disease. Neurologist. 2008;14:299-306. View abstract.
  866. Anand, P., Thomas, S. G., Kunnumakkara, A. B., Sundaram, C., Harikumar, K. B., Sung, B., Tharakan, S. T., Misra, K., Priyadarsini, I. K., Rajasekharan, K. N., and Aggarwal, B. B. Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature. Biochem.Pharmacol 12-1-2008;76:1590-1611. View abstract.
  867. Hegge, A. B., Schuller, R. B., Kristensen, S., and Tonnesen, H. H. In vitro release of curcumin from vehicles containing alginate and cyclodextrin. Studies of curcumin and curcuminoides. XXXIII. Pharmazie 2008;63:585-592. View abstract.
  868. Aggarwal, B. B. Prostate cancer and curcumin: add spice to your life. Cancer Biol.Ther. 2008;7:1436-1440. View abstract.
  869. Tanaka, K., Kuba, Y., Sasaki, T., Hiwatashi, F., and Komatsu, K. Quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis. J Agric.Food Chem. 10-8-2008;56:8787-8792. View abstract.
  870. von, Metzler, I, Krebbel, H., Kuckelkorn, U., Heider, U., Jakob, C., Kaiser, M., Fleissner, C., Terpos, E., and Sezer, O. Curcumin diminishes human osteoclastogenesis by inhibition of the signalosome-associated I kappaB kinase. J Cancer Res Clin Oncol. 2009;135:173-179. View abstract.
  871. Kulkarni, S. K., Bhutani, M. K., and Bishnoi, M. Antidepressant activity of curcumin: involvement of serotonin and dopamine system. Psychopharmacology (Berl) 2008;201:435-442. View abstract.
  872. Reuter, S., Eifes, S., Dicato, M., Aggarwal, B. B., and Diederich, M. Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem.Pharmacol 12-1-2008;76:1340-1351. View abstract.
  873. Memis, D., Hekimoglu, S., Sezer, A., Altaner, S., Sut, N., and Usta, U. Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. Nutrition 2008;24(11-12):1133-1138. View abstract.
  874. Wakade, C., King, M. D., Laird, M. D., Alleyne, C. H., Jr., and Dhandapani, K. M. Curcumin attenuates vascular inflammation and cerebral vasospasm after subarachnoid hemorrhage in mice. Antioxid.Redox.Signal. 2009;11:35-45. View abstract.
  875. Chen, B., Zhang, D. P., and Gao, W. [Effect of curcumin on the expression of collagen type I protein and transforming growth factor-beta1mRNA in pulmonary fibrosis rats]. Zhonghua Lao.Dong.Wei Sheng Zhi.Ye.Bing.Za Zhi. 2008;26:257-261. View abstract.
  876. Sahoo, D. K., Roy, A., and Chainy, G. B. Protective effects of vitamin E and curcumin on L-thyroxine-induced rat testicular oxidative stress. Chem.Biol.Interact. 11-25-2008;176(2-3):121-128. View abstract.
  877. Zhang, J. S., Guan, J., Yang, F. Q., Liu, H. G., Cheng, X. J., and Li, S. P. Qualitative and quantitative analysis of four species of Curcuma rhizomes using twice development thin layer chromatography. J Pharm Biomed.Anal. 11-4-2008;48:1024-1028. View abstract.
  878. Adhvaryu, M. R., Reddy, N., and Vakharia, B. C. Prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach. World J Gastroenterol. 8-14-2008;14:4753-4762. View abstract.
  879. Foller, M., Huber, S. M., and Lang, F. Erythrocyte programmed cell death. IUBMB.Life 2008;60:661-668. View abstract.
  880. Dempe, J. S., Pfeiffer, E., Grimm, A. S., and Metzler, M. Metabolism of curcumin and induction of mitotic catastrophe in human cancer cells. Mol.Nutr.Food Res 2008;52:1074-1081. View abstract.
  881. Thangapazham, R. L., Shaheduzzaman, S., Kim, K. H., Passi, N., Tadese, A., Vahey, M., Dobi, A., Srivastava, S., and Maheshwari, R. K. Androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome. Cancer Biol.Ther. 2008;7:1427-1435. View abstract.
  882. Oh, S., Kyung, T. W., and Choi, H. S. Curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappaB ligand (RANKL) in bone marrow stromal cells. Mol.Cells 11-30-2008;26:486-489. View abstract.
  883. Ghoneim, A. I. Effects of curcumin on ethanol-induced hepatocyte necrosis and apoptosis: implication of lipid peroxidation and cytochrome c. Naunyn Schmiedebergs Arch.Pharmacol 2009;379:47-60. View abstract.
  884. Moon, D. O., Kim, M. O., Lee, H. J., Choi, Y. H., Park, Y. M., Heo, M. S., and Kim, G. Y. Curcumin attenuates ovalbumin-induced airway inflammation by regulating nitric oxide. Biochem.Biophys.Res Commun. 10-17-2008;375:275-279. View abstract.
  885. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Tsutsumi, V., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin prevents and reverses cirrhosis induced by bile duct obstruction or CCl4 in rats: role of TGF-beta modulation and oxidative stress. Fundam.Clin Pharmacol 2008;22:417-427. View abstract.
  886. Dou, X., Fan, C., Wo, L., Yan, J., Qian, Y., and Wo, X. Curcumin up-regulates LDL receptor expression via the sterol regulatory element pathway in HepG2 cells. Planta Med. 2008;74:1374-1379. View abstract.
  887. Pan, R., Qiu, S., Lu, D. X., and Dong, J. Curcumin improves learning and memory ability and its neuroprotective mechanism in mice. Chin Med.J (Engl) 5-5-2008;121:832-839. View abstract.
  888. Illouz, S., Alexandre, E., Pattenden, C., Mark, L., Bachellier, P., Webb, M., Berry, D., Dennison, A., and Richert, L. Differential effects of curcumin on cryopreserved versus fresh primary human hepatocytes. Phytother.Res 2008;22:1688-1691. View abstract.
  889. Kanitkar, M., Gokhale, K., Galande, S., and Bhonde, R. R. Novel role of curcumin in the prevention of cytokine-induced islet death in vitro and diabetogenesis in vivo. Br.J Pharmacol 2008;155:702-713. View abstract.
  890. Shimmyo, Y., Kihara, T., Akaike, A., Niidome, T., and Sugimoto, H. Epigallocatechin-3-gallate and curcumin suppress amyloid beta-induced beta-site APP cleaving enzyme-1 upregulation. Neuroreport 8-27-2008;19:1329-1333. View abstract.
  891. Garg, R., Ingle, A., and Maru, G. Dietary turmeric modulates DMBA-induced p21ras, MAP kinases and AP-1/NF-kappaB pathway to alter cellular responses during hamster buccal pouch carcinogenesis. Toxicol Appl.Pharmacol 11-1-2008;232:428-439. View abstract.
  892. Eybl, V., Kotyzova, D., Cerna, P., and Koutensky, J. Effect of melatonin, curcumin, quercetin, and resveratrol on acute ferric nitrilotriacetate (Fe-NTA)-induced renal oxidative damage in rats. Hum.Exp.Toxicol 2008;27:347-353. View abstract.
  893. Wang, W. X., Sun, S. Z., Guo, X. L., and Song, Y. [Effect of curcumin on invasion and migration of tongue squamous cell carcinoma cell line Tca8113]. Zhonghua Kou Qiang.Yi.Xue.Za Zhi. 2008;43:101-104. View abstract.
  894. Sotanaphun, U., Phattanawasin, P., and Sriphong, L. Application of Scion image software to the simultaneous determination of curcuminoids in turmeric (Curcuma longa). Phytochem.Anal. 2009;20:19-23. View abstract.
  895. Tsui, K. H., Feng, T. H., Lin, C. M., Chang, P. L., and Juang, H. H. Curcumin blocks the activation of androgen and interlukin-6 on prostate-specific antigen expression in human prostatic carcinoma cells. J Androl 2008;29:661-668. View abstract.
  896. Davis, C. D. and Ross, S. A. Evidence for dietary regulation of microRNA expression in cancer cells. Nutr.Rev. 2008;66:477-482.View abstract.
  897. Aggarwal, B. B. and Harikumar, K. B. Potential therapeutic effects of curcumin, the anti-inflammatory agent, against neurodegenerative, cardiovascular, pulmonary, metabolic, autoimmune and neoplastic diseases. Int.J Biochem.Cell Biol. 2009;41:40-59. View abstract.
  898. Zhang, X. G., Wang, D. M., and Huang, Q. [Study on extracting process for Tiao ZhiAn mixture]. Zhong.Yao Cai. 2008;31:594-597.View abstract.
  899. Han, G., Bi, R., Le, Q., Zhao, L. L., Dong, Y., and Lin, Q. H. [Study on effect of demethoxycurcumin in Curcuma long on stability of curcumin]. Zhong.Yao Cai. 2008;31:592-594. View abstract.
  900. Bharal, N., Sahaya, K., Jain, S., Mediratta, P. K., and Sharma, K. K. Curcumin has anticonvulsant activity on increasing current electroshock seizures in mice. Phytother.Res 2008;22:1660-1664. View abstract.
  901. Sameermahmood, Z., Balasubramanyam, M., Saravanan, T., and Rema, M. Curcumin modulates SDF-1alpha/CXCR4-induced migration of human retinal endothelial cells (HRECs). Invest Ophthalmol.Vis.Sci. 2008;49:3305-3311. View abstract.
  902. Mattson, M. P., Son, T. G., and Camandola, S. Viewpoint: mechanisms of action and therapeutic potential of neurohormetic phytochemicals. Dose.Response 2007;5:174-186. View abstract.
  903. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in serum of mice. Acta Pol.Pharm 2008;65:339-343. View abstract.
  904. Zhao, J., Zhao, Y., Zheng, W., Lu, Y., Feng, G., and Yu, S. Neuroprotective effect of curcumin on transient focal cerebral ischemia in rats. Brain Res 9-10-2008;1229:224-232. View abstract.
  905. Shirley, S. A., Montpetit, A. J., Lockey, R. F., and Mohapatra, S. S. Curcumin prevents human dendritic cell response to immune stimulants. Biochem.Biophys.Res Commun. 9-26-2008;374:431-436. View abstract.
  906. Maher, P., Akaishi, T., Schubert, D., and Abe, K. A pyrazole derivative of curcumin enhances memory. Neurobiol.Aging 2010;31:706-709. View abstract.
  907. Fiorillo, C., Becatti, M., Pensalfini, A., Cecchi, C., Lanzilao, L., Donzelli, G., Nassi, N., Giannini, L., Borchi, E., and Nassi, P. Curcumin protects cardiac cells against ischemia-reperfusion injury: effects on oxidative stress, NF-kappaB, and JNK pathways. Free Radic.Biol.Med. 9-15-2008;45:839-846. View abstract.
  908. Dhillon, N., Aggarwal, B. B., Newman, R. A., Wolff, R. A., Kunnumakkara, A. B., Abbruzzese, J. L., Ng, C. S., Badmaev, V., and Kurzrock, R. Phase II trial of curcumin in patients with advanced pancreatic cancer. Clin Cancer Res 7-15-2008;14:4491-4499.View abstract.
  909. Li, Y., Li, S., Han, Y., Liu, J., Zhang, J., Li, F., Wang, Y., Liu, X., and Yao, L. Calebin-A induces apoptosis and modulates MAPK family activity in drug resistant human gastric cancer cells. Eur.J Pharmacol 9-4-2008;591(1-3):252-258. View abstract.
  910. Hong, W., Chen, D. W., Zhao, X. L., Qiao, M. X., and Hu, H. Y. [Preparation and study in vitro of long-circulating nanoliposomes of curcumin]. Zhongguo Zhong.Yao Za Zhi. 2008;33:889-892. View abstract.
  911. Xu, D. H., Wang, S., Mei, X. T., Luo, X. J., and Xu, S. B. [Studies on solubility enhancement of curcumin by Polyvinylpyrrolidione K30]. Zhong.Yao Cai. 2008;31:438-442. View abstract.
  912. Dohare, P., Garg, P., Jain, V., Nath, C., and Ray, M. Dose dependence and therapeutic window for the neuroprotective effects of curcumin in thromboembolic model of rat. Behav.Brain Res 11-21-2008;193:289-297. View abstract.
  913. Wang, W. Z., Cheng, J., Luo, J., and Zhuang, S. M. Abrogation of G2/M arrest sensitizes curcumin-resistant hepatoma cells to apoptosis. FEBS Lett. 8-6-2008;582:2689-2695. View abstract.
  914. Sun, D. I., Nizamutdinova, I. T., Kim, Y. M., Cai, X. F., Lee, J. J., Kang, S. S., Kim, Y. S., Kang, K. M., Chai, G. Y., Chang, K. C., and Kim, H. J. Bisacurone inhibits adhesion of inflammatory monocytes or cancer cells to endothelial cells through down-regulation of VCAM-1 expression. Int.Immunopharmacol. 2008;8:1272-1281. View abstract.
  915. Shishu, Gupta, N., and Aggarwal, N. Bioavailability enhancement and targeting of stomach tumors using gastro-retentive floating drug delivery system of curcumin--"a technical note". AAPS.PharmSciTech. 2008;9:810-813. View abstract.
  916. Srinivasan, M., Sudheer, A. R., Rajasekaran, K. N., and Menon, V. P. Effect of curcumin analog on gamma-radiation-induced cellular changes in primary culture of isolated rat hepatocytes in vitro. Chem.Biol.Interact. 10-22-2008;176:1-8. View abstract.
  917. Binion, D. G., Otterson, M. F., and Rafiee, P. Curcumin inhibits VEGF-mediated angiogenesis in human intestinal microvascular endothelial cells through COX-2 and MAPK inhibition. Gut 2008;57:1509-1517. View abstract.
  918. Chadalapaka, G., Jutooru, I., Chintharlapalli, S., Papineni, S., Smith, R., III, Li, X., and Safe, S. Curcumin decreases specificity protein expression in bladder cancer cells. Cancer Res 7-1-2008;68:5345-5354. View abstract.
  919. Narasimhan, M. and Ammanamanchi, S. Curcumin blocks RON tyrosine kinase-mediated invasion of breast carcinoma cells. Cancer Res 7-1-2008;68:5185-5192. View abstract.
  920. Usharani, P., Mateen, A. A., Naidu, M. U., Raju, Y. S., and Chandra, N. Effect of NCB-02, atorvastatin and placebo on endothelial function, oxidative stress and inflammatory markers in patients with type 2 diabetes mellitus: a randomized, parallel-group, placebo-controlled, 8-week study. Drugs R.D. 2008;9:243-250. View abstract.
  921. Kumar, A. and Singh, A. Possible nitric oxide modulation in protective effect of (Curcuma longa, Zingiberaceae) against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Phytomedicine. 2008;15:577-586. View abstract.
  922. Lin, R., Chen, X., Li, W., Han, Y., Liu, P., and Pi, R. Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin. Neurosci.Lett. 8-8-2008;440:344-347. View abstract.
  923. Park, S. Y., Kim, H. S., Cho, E. K., Kwon, B. Y., Phark, S., Hwang, K. W., and Sul, D. Curcumin protected PC12 cells against beta-amyloid-induced toxicity through the inhibition of oxidative damage and tau hyperphosphorylation. Food Chem.Toxicol 2008;46:2881-2887. View abstract.
  924. Banerjee, A., Kunwar, A., Mishra, B., and Priyadarsini, K. I. Concentration dependent antioxidant/pro-oxidant activity of curcumin studies from AAPH induced hemolysis of RBCs. Chem.Biol.Interact. 7-30-2008;174:134-139. View abstract.
  925. Pathak, N. and Khandelwal, S. Comparative efficacy of piperine, curcumin and picroliv against Cd immunotoxicity in mice. Biometals 2008;21:649-661. View abstract.
  926. Vareed, S. K., Kakarala, M., Ruffin, M. T., Crowell, J. A., Normolle, D. P., Djuric, Z., and Brenner, D. E. Pharmacokinetics of curcumin conjugate metabolites in healthy human subjects. Cancer Epidemiol.Biomarkers Prev. 2008;17:1411-1417. View abstract.
  927. Malik, M., Mendoza, M., Payson, M., and Catherino, W. H. Curcumin, a nutritional supplement with antineoplastic activity, enhances leiomyoma cell apoptosis and decreases fibronectin expression. Fertil.Steril. 2009;91(5 Suppl):2177-2184. View abstract.
  928. Yang, C. S., Sang, S., Lambert, J. D., and Lee, M. J. Bioavailability issues in studying the health effects of plant polyphenolic compounds. Mol.Nutr.Food Res 2008;52 Suppl 1:S139-S151. View abstract.
  929. Candan, N. and Tuzmen, N. Very rapid quantification of malondialdehyde (MDA) in rat brain exposed to lead, aluminium and phenolic antioxidants by high-performance liquid chromatography-fluorescence detection. Neurotoxicology 2008;29:708-713.View abstract.
  930. Gonzales, A. M. and Orlando, R. A. Curcumin and resveratrol inhibit nuclear factor-kappaB-mediated cytokine expression in adipocytes. Nutr.Metab (Lond) 2008;5:17. View abstract.
  931. Ak, T. and Gulcin, I. Antioxidant and radical scavenging properties of curcumin. Chem.Biol.Interact. 7-10-2008;174:27-37. View abstract.
  932. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced lipid peroxidation in liver, kidney and testis of mice--an in vitro study. Acta Pol.Pharm 2007;64:413-416. View abstract.
  933. Sahu, A., Bora, U., Kasoju, N., and Goswami, P. Synthesis of novel biodegradable and self-assembling methoxy poly(ethylene glycol)-palmitate nanocarrier for curcumin delivery to cancer cells. Acta Biomater. 2008;4:1752-1761. View abstract.
  934. Araki, Y., Fann, M., Wersto, R., and Weng, N. P. Histone acetylation facilitates rapid and robust memory CD8 T cell response through differential expression of effector molecules (eomesodermin and its targets: perforin and granzyme B). J Immunol. 6-15-2008;180:8102-8108. View abstract.
  935. Papiez, M. A., Kaja, M., and Gebarowska, A. Age-dependent different action of curcumin in thyroid of rat. Folia Histochem.Cytobiol. 2008;46:205-211. View abstract.
  936. Sun, Y., Lee, C. C., Hung, W. C., Chen, F. Y., Lee, M. T., and Huang, H. W. The bound states of amphipathic drugs in lipid bilayers: study of curcumin. Biophys.J 2008;95:2318-2324. View abstract.
  937. Bandyopadhyaya, G., Sinha, S., Chattopadhyay, B. D., and Chakraborty, A. Protective role of curcumin against nicotine-induced genotoxicity on rat liver under restricted dietary protein. Eur.J Pharmacol 7-7-2008;588(2-3):151-157. View abstract.
  938. Das, R., Roy, A., Dutta, N., and Majumder, H. K. Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani. Apoptosis. 2008;13:867-882. View abstract.
  939. Tong, K. M., Shieh, D. C., Chen, C. P., Tzeng, C. Y., Wang, S. P., Huang, K. C., Chiu, Y. C., Fong, Y. C., and Tang, C. H. Leptin induces IL-8 expression via leptin receptor, IRS-1, PI3K, Akt cascade and promotion of NF-kappaB/p300 binding in human synovial fibroblasts. Cell Signal. 2008;20:1478-1488. View abstract.
  940. Bian, F., Zhang, M. C., and Zhu, Y. Inhibitory effect of curcumin on corneal neovascularization in vitro and in vivo. Ophthalmologica 2008;222:178-186. View abstract.
  941. Lopez-Lazaro, M. Anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent. Mol.Nutr.Food Res 2008;52 Suppl 1:S103-S127. View abstract.
  942. Yodkeeree, S., Chaiwangyen, W., Garbisa, S., and Limtrakul, P. Curcumin, demethoxycurcumin and bisdemethoxycurcumin differentially inhibit cancer cell invasion through the down-regulation of MMPs and uPA. J Nutr.Biochem. 2009;20:87-95. View abstract.
  943. Bakhshi, J., Weinstein, L., Poksay, K. S., Nishinaga, B., Bredesen, D. E., and Rao, R. V. Coupling endoplasmic reticulum stress to the cell death program in mouse melanoma cells: effect of curcumin. Apoptosis. 2008;13:904-914. View abstract.
  944. Gowda, N. K., Ledoux, D. R., Rottinghaus, G. E., Bermudez, A. J., and Chen, Y. C. Efficacy of turmeric (Curcuma longa), containing a known level of curcumin, and a hydrated sodium calcium aluminosilicate to ameliorate the adverse effects of aflatoxin in broiler chicks. Poult.Sci. 2008;87:1125-1130. View abstract.
  945. Dohare, P., Varma, S., and Ray, M. Curcuma oil modulates the nitric oxide system response to cerebral ischemia/reperfusion injury. Nitric.Oxide. 2008;19:1-11. View abstract.
  946. Pari, L., Tewas, D., and Eckel, J. Role of curcumin in health and disease. Arch.Physiol Biochem. 2008;114:127-149. View abstract.
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  948. Braumann, C., Tangermann, J., Jacobi, C. A., Muller, J. M., and Dubiel, W. Novel anti-angiogenic compounds for application in tumor therapy - COP9 signalosome-associated kinases as possible targets. Mini.Rev.Med.Chem. 2008;8:421-428. View abstract.
  949. Carroll, C. E., Ellersieck, M. R., and Hyder, S. M. Curcumin inhibits MPA-induced secretion of VEGF from T47-D human breast cancer cells. Menopause. 2008;15:570-574. View abstract.
  950. Chearwae, W. and Bright, J. J. 15-deoxy-Delta-prostaglandin J and curcumin modulate the expression of toll-like receptors 4 and 9 in autoimmune T lymphocyte. J Clin Immunol. 2008;28:558-570. View abstract.
  951. McPhee, D. Withdrawn paper: antibacterial effect of five Zingiberaceae essential oils by Laohakunjit et al., Molecules 2007, 12. Molecules. 2008;13:488-489. View abstract.
  952. Shen, Y. and Yu, L. C. Potential protection of curcumin against hypoxia-induced decreases in beta-III tubulin content in rat prefrontal cortical neurons. Neurochem.Res 2008;33:2112-2117. View abstract.
  953. Leung, M. H., Colangelo, H., and Kee, T. W. Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis. Langmuir 6-3-2008;24:5672-5675. View abstract.
  954. Boriwanwattanarak, P., Ingkaninan, K., Khorana, N., and Viyoch, J. Development of curcuminoids hydrogel patch using chitosan from various sources as controlled-release matrix. Int.J Cosmet.Sci. 2008;30:205-218. View abstract.
  955. Rolland, S. G. and Bruel, C. A. Sulphur and nitrogen regulation of the protease-encoding ACP1 gene in the fungus Botrytis cinerea: correlation with a phospholipase D activity. Microbiology 2008;154(Pt 5):1464-1473. View abstract.
  956. Miller, M., Chen, S., Woodliff, J., and Kansra, S. Curcumin (diferuloylmethane) inhibits cell proliferation, induces apoptosis, and decreases hormone levels and secretion in pituitary tumor cells. Endocrinology 2008;149:4158-4167. View abstract.
  957. Guo, L. Y., Cai, X. F., Lee, J. J., Kang, S. S., Shin, E. M., Zhou, H. Y., Jung, J. W., and Kim, Y. S. Comparison of suppressive effects of demethoxycurcumin and bisdemethoxycurcumin on expressions of inflammatory mediators in vitro and in vivo. Arch.Pharm Res 2008;31:490-496. View abstract.
  958. Kochhar, S. and Kochhar, V. K. Identification and characterization of a super-stable Cu-Zn SOD from leaves of turmeric (Curcuma longa L.). Planta 2008;228:307-318. View abstract.
  959. Zhu, J., Zeng, X., O'Neal, M., Schultz, G., Tucker, B., Coats, J., Bartholomay, L., and Xue, R. D. Mosquito larvicidal activity of botanical-based mosquito repellents. J Am.Mosq.Control Assoc. 2008;24:161-168. View abstract.
  960. Tang, J., Wang, J., Pan, C., Ren, L., and Huang, N. [Preparation and anticoagulation of curcumin/poly(lactic acid-co-glycol acid) composite films]. Sheng Wu Yi.Xue.Gong.Cheng Xue.Za Zhi. 2008;25:113-116. View abstract.
  961. Yuan, H. Y., Kuang, S. Y., Zheng, X., Ling, H. Y., Yang, Y. B., Yan, P. K., Li, K., and Liao, D. F. Curcumin inhibits cellular cholesterol accumulation by regulating SREBP-1/caveolin-1 signaling pathway in vascular smooth muscle cells. Acta Pharmacol Sin. 2008;29:555-563. View abstract.
  962. Thangapazham, R. L., Puri, A., Tele, S., Blumenthal, R., and Maheshwari, R. K. Evaluation of a nanotechnology-based carrier for delivery of curcumin in prostate cancer cells. Int.J Oncol. 2008;32:1119-1123. View abstract.
  963. Meja, K. K., Rajendrasozhan, S., Adenuga, D., Biswas, S. K., Sundar, I. K., Spooner, G., Marwick, J. A., Chakravarty, P., Fletcher, D., Whittaker, P., Megson, I. L., Kirkham, P. A., and Rahman, I. Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2. Am.J Respir.Cell Mol.Biol. 2008;39:312-323. View abstract.
  964. Wang, R., Li, Y. B., Li, Y. H., Xu, Y., Wu, H. L., and Li, X. J. Curcumin protects against glutamate excitotoxicity in rat cerebral cortical neurons by increasing brain-derived neurotrophic factor level and activating TrkB. Brain Res 5-19-2008;1210:84-91. View abstract.
  965. Begum, A. N., Jones, M. R., Lim, G. P., Morihara, T., Kim, P., Heath, D. D., Rock, C. L., Pruitt, M. A., Yang, F., Hudspeth, B., Hu, S., Faull, K. F., Teter, B., Cole, G. M., and Frautschy, S. A. Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp.Ther. 2008;326:196-208. View abstract.
  966. Feng, B., Chen, S., Chiu, J., George, B., and Chakrabarti, S. Regulation of cardiomyocyte hypertrophy in diabetes at the transcriptional level. Am.J Physiol Endocrinol.Metab 2008;294:E1119-E1126. View abstract.
  967. Huang, S., Zhao, L., Kim, K., Lee, D. S., and Hwang, D. H. Inhibition of Nod2 signaling and target gene expression by curcumin. Mol.Pharmacol 2008;74:274-281. View abstract.
  968. Vijayalakshmi, B., Kumar, G. S., and Salimath, P. V. Effect of bitter gourd and spent turmeric on glycoconjugate metabolism in streptozotocin-induced diabetic rats. J Diabetes Complications 2009;23:71-76. View abstract.
  969. Rajeswari, A. and Sabesan, M. Inhibition of monoamine oxidase-B by the polyphenolic compound, curcumin and its metabolite tetrahydrocurcumin, in a model of Parkinson's disease induced by MPTP neurodegeneration in mice. Inflammopharmacology. 2008;16:96-99. View abstract.
  970. Weisberg, S. P., Leibel, R., and Tortoriello, D. V. Dietary curcumin significantly improves obesity-associated inflammation and diabetes in mouse models of diabesity. Endocrinology 2008;149:3549-3558. View abstract.
  971. Kurup, V. P. and Barrios, C. S. Immunomodulatory effects of curcumin in allergy. Mol.Nutr.Food Res 2008;52:1031-1039. View abstract.
  972. Seo, K. I., Choi, M. S., Jung, U. J., Kim, H. J., Yeo, J., Jeon, S. M., and Lee, M. K. Effect of curcumin supplementation on blood glucose, plasma insulin, and glucose homeostasis related enzyme activities in diabetic db/db mice. Mol.Nutr.Food Res 2008;52:995-1004. View abstract.
  973. Chen, W., Bacanamwo, M., and Harrison, D. G. Activation of p300 histone acetyltransferase activity is an early endothelial response to laminar shear stress and is essential for stimulation of endothelial nitric-oxide synthase mRNA transcription. J Biol.Chem. 6-13-2008;283:16293-16298. View abstract.
  974. Yoysungnoen, P., Wirachwong, P., Changtam, C., Suksamrarn, A., and Patumraj, S. Anti-cancer and anti-angiogenic effects of curcumin and tetrahydrocurcumin on implanted hepatocellular carcinoma in nude mice. World J Gastroenterol. 4-7-2008;14:2003-2009. View abstract.
  975. Lee, J. H., Kim, J. W., Ko, N. Y., Mun, S. H., Her, E., Kim, B. K., Han, J. W., Lee, H. Y., Beaven, M. A., Kim, Y. M., and Choi, W. S. Curcumin, a constituent of curry, suppresses IgE-mediated allergic response and mast cell activation at the level of Syk. J Allergy Clin Immunol. 2008;121:1225-1231. View abstract.
  976. Dong, J., Lu, D. X., Pan, R., and Tang, H. M. [Effect and mechanism of curcumin on learning and memory dysfunction induced by gp120 in rats]. Xi.Bao.Yu Fen.Zi.Mian.Yi.Xue.Za Zhi. 2008;24:328-331. View abstract.
  977. Mukherjee, S., Roy, M., Dey, S., and Bhattacharya, R. K. A Mechanistic Approach for Modulation of Arsenic Toxicity in Human Lymphocytes by Curcumin, an Active Constituent of Medicinal Herb Curcuma longa Linn. J Clin Biochem.Nutr. 2007;41:32-42.View abstract.
  978. Varalakshmi, Ch, Ali, A. M., Pardhasaradhi, B. V., Srivastava, R. M., Singh, S., and Khar, A. Immunomodulatory effects of curcumin: in-vivo. Int.Immunopharmacol. 2008;8:688-700. View abstract.
  979. Mackenzie, G. G., Queisser, N., Wolfson, M. L., Fraga, C. G., Adamo, A. M., and Oteiza, P. I. Curcumin induces cell-arrest and apoptosis in association with the inhibition of constitutively active NF-kappaB and STAT3 pathways in Hodgkin's lymphoma cells. Int.J Cancer 7-1-2008;123:56-65. View abstract.
  980. Freudlsperger, C., Greten, J., and Schumacher, U. Curcumin induces apoptosis in human neuroblastoma cells via inhibition of NFkappaB. Anticancer Res 2008;28(1A):209-214. View abstract.
  981. Kunnumakkara, A. B., Diagaradjane, P., Guha, S., Deorukhkar, A., Shentu, S., Aggarwal, B. B., and Krishnan, S. Curcumin sensitizes human colorectal cancer xenografts in nude mice to gamma-radiation by targeting nuclear factor-kappaB-regulated gene products. Clin Cancer Res 4-1-2008;14:2128-2136. View abstract.
  982. Jia, L., Wang, H., Qu, S., Miao, X., and Zhang, J. CD147 regulates vascular endothelial growth factor-A expression, tumorigenicity, and chemosensitivity to curcumin in hepatocellular carcinoma. IUBMB.Life 2008;60:57-63. View abstract.
  983. Sun, J., Guo, W., Ben, Y., Jiang, J., Tan, C., Xu, Z., Wang, X., and Bai, C. Preventive effects of curcumin and dexamethasone on lung transplantation-associated lung injury in rats. Crit Care Med. 2008;36:1205-1213. View abstract.
  984. Subudhi, U., Das, K., Paital, B., Bhanja, S., and Chainy, G. B. Alleviation of enhanced oxidative stress and oxygen consumption of L-thyroxine induced hyperthyroid rat liver mitochondria by vitamin E and curcumin. Chem.Biol.Interact. 5-28-2008;173:105-114.View abstract.
  985. Murugan, P., Pari, L., and Rao, C. A. Effect of tetrahydrocurcumin on insulin receptor status in type 2 diabetic rats: studies on insulin binding to erythrocytes. J Biosci. 2008;33:63-72. View abstract.
  986. Bayrak, O., Uz, E., Bayrak, R., Turgut, F., Atmaca, A. F., Sahin, S., Yildirim, M. E., Kaya, A., Cimentepe, E., and Akcay, A. Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J Urol. 2008;26:285-291. View abstract.
  987. Elseweidy, M. M., Younis, N. N., Amin, R. S., Abdallah, F. R., Fathy, A. M., and Yousif, Z. A. Effect of some natural products either alone or in combination on gastritis induced in experimental rats. Dig.Dis.Sci. 2008;53:1774-1784. View abstract.
  988. Yang, S., Zhang, D., Yang, Z., Hu, X., Qian, S., Liu, J., Wilson, B., Block, M., and Hong, J. S. Curcumin protects dopaminergic neuron against LPS induced neurotoxicity in primary rat neuron/glia culture. Neurochem.Res 2008;33:2044-2053. View abstract.
  989. Kim, S. J., Son, T. G., Park, H. R., Park, M., Kim, M. S., Kim, H. S., Chung, H. Y., Mattson, M. P., and Lee, J. Curcumin stimulates proliferation of embryonic neural progenitor cells and neurogenesis in the adult hippocampus. J Biol.Chem. 5-23-2008;283:14497-14505. View abstract.
  990. Hsu, H. Y., Chu, L. C., Hua, K. F., and Chao, L. K. Heme oxygenase-1 mediates the anti-inflammatory effect of Curcumin within LPS-stimulated human monocytes. J Cell Physiol 2008;215:603-612. View abstract.
  991. Novak, Kujundzic R., Grbesa, I., Ivkic, M., Katdare, M., and Gall-Troselj, K. Curcumin downregulates H19 gene transcription in tumor cells. J Cell Biochem. 8-1-2008;104:1781-1792. View abstract.
  992. Sun, M., Estrov, Z., Ji, Y., Coombes, K. R., Harris, D. H., and Kurzrock, R. Curcumin (diferuloylmethane) alters the expression profiles of microRNAs in human pancreatic cancer cells. Mol.Cancer Ther. 2008;7:464-473. View abstract.
  993. Ma, Q. L., Yang, F., Calon, F., Ubeda, O. J., Hansen, J. E., Weisbart, R. H., Beech, W., Frautschy, S. A., and Cole, G. M. p21-activated kinase-aberrant activation and translocation in Alzheimer disease pathogenesis. J Biol.Chem. 5-16-2008;283:14132-14143. View abstract.
  994. Abu-Rizq, H. A., Mansour, M. H., Safer, A. M., and Afzal, M. Cyto-protective and immunomodulating effect of Curcuma longa in Wistar rats subjected to carbon tetrachloride-induced oxidative stress. Inflammopharmacology. 2008;16:87-95. View abstract.
  995. Lin, J. and Chen, A. Activation of peroxisome proliferator-activated receptor-gamma by curcumin blocks the signaling pathways for PDGF and EGF in hepatic stellate cells. Lab Invest 2008;88:529-540. View abstract.
  996. Antonio, A. M. and Druse, M. J. Antioxidants prevent ethanol-associated apoptosis in fetal rhombencephalic neurons. Brain Res 4-14-2008;1204:16-23. View abstract.
  997. Dinkova-Kostova, A. T. and Talalay, P. Direct and indirect antioxidant properties of inducers of cytoprotective proteins. Mol.Nutr.Food Res 2008;52 Suppl 1:S128-S138. View abstract.
  998. Kim, K. M., Pae, H. O., Zhung, M., Ha, H. Y., Ha, Y. A., Chai, K. Y., Cheong, Y. K., Kim, J. M., and Chung, H. T. Involvement of anti-inflammatory heme oxygenase-1 in the inhibitory effect of curcumin on the expression of pro-inflammatory inducible nitric oxide synthase in RAW264.7 macrophages. Biomed.Pharmacother. 2008;62:630-636. View abstract.
  999. Hatcher, H., Planalp, R., Cho, J., Torti, F. M., and Torti, S. V. Curcumin: from ancient medicine to current clinical trials. Cell Mol.Life Sci. 2008;65:1631-1652. View abstract.
  1000. Mathuria, N. and Verma, R. J. Ameliorative effect of curcumin on aflatoxin-induced toxicity in DNA, RNA and protein in liver and kidney of mice. Acta Pol.Pharm 2007;64:497-502. View abstract.
  1001. Shu, J. C., Wang, H. L., Ye, G. R., He, Y. J., Lu, X., and Fang, L. [The study of therapeutic effects of curcumin on hepatic fibrosis and variation of correlated cytokine]. Zhong.Yao Cai. 2007;30:1421-1425. View abstract.
  1002. Garg, R., Gupta, S., and Maru, G. B. Dietary curcumin modulates transcriptional regulators of phase I and phase II enzymes in benzo[a]pyrene-treated mice: mechanism of its anti-initiating action. Carcinogenesis 2008;29:1022-1032. View abstract.
  1003. Bichucher, A. M. and Kozlov, L. V. [Effect of medicinal preparations on the complement: inhibition of subcomponent C1q binding to a target]. Eksp.Klin.Farmakol. 2007;70:25-28. View abstract.
  1004. Choi, B. H., Kim, C. G., Bae, Y. S., Lim, Y., Lee, Y. H., and Shin, S. Y. p21 Waf1/Cip1 expression by curcumin in U-87MG human glioma cells: role of early growth response-1 expression. Cancer Res. 3-1-2008;68:1369-1377. View abstract.
  1005. Wu, C. Y., Hsieh, H. L., Sun, C. C., Tseng, C. P., and Yang, C. M. IL-1 beta induces proMMP-9 expression via c-Src-dependent PDGFR/PI3K/Akt/p300 cascade in rat brain astrocytes. J Neurochem. 2008;105:1499-1512. View abstract.
  1006. Ding, Z. S., Jiang, F. S., Chen, N. P., Lv, G. Y., and Zhu, C. G. Isolation and identification of an anti-tumor component from leaves of Impatiens balsamina. Molecules. 2008;13:220-229. View abstract.
  1007. Aravindan, N., Madhusoodhanan, R., Ahmad, S., Johnson, D., and Herman, T. S. Curcumin inhibits NFkappaB mediated radioprotection and modulate apoptosis related genes in human neuroblastoma cells. Cancer Biol.Ther. 2008;7:569-576. View abstract.
  1008. Panchal, H. D., Vranizan, K., Lee, C. Y., Ho, J., Ngai, J., and Timiras, P. S. Early anti-oxidative and anti-proliferative curcumin effects on neuroglioma cells suggest therapeutic targets. Neurochem.Res 2008;33:1701-1710. View abstract.
  1009. Morimoto, T., Sunagawa, Y., Kawamura, T., Takaya, T., Wada, H., Nagasawa, A., Komeda, M., Fujita, M., Shimatsu, A., Kita, T., and Hasegawa, K. The dietary compound curcumin inhibits p300 histone acetyltransferase activity and prevents heart failure in rats. J Clin Invest 2008;118:868-878. View abstract.
  1010. Li, H. L., Liu, C., de Couto, G., Ouzounian, M., Sun, M., Wang, A. B., Huang, Y., He, C. W., Shi, Y., Chen, X., Nghiem, M. P., Liu, Y., Chen, M., Dawood, F., Fukuoka, M., Maekawa, Y., Zhang, L., Leask, A., Ghosh, A. K., Kirshenbaum, L. A., and Liu, P. P. Curcumin prevents and reverses murine cardiac hypertrophy. J Clin Invest 2008;118:879-893. View abstract.
  1011. Kaur, C. and Ling, E. A. Blood brain barrier in hypoxic-ischemic conditions. Curr.Neurovasc.Res 2008;5:71-81. View abstract.
  1012. Rudrappa, T. and Bais, H. P. Curcumin, a known phenolic from Curcuma longa, attenuates the virulence of Pseudomonas aeruginosa PAO1 in whole plant and animal pathogenicity models. J Agric.Food Chem. 3-26-2008;56:1955-1962. View abstract.
  1013. Jacob, A., Wu, R., Zhou, M., and Wang, P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-gamma Activation. PPAR.Res 2007;2007:89369. View abstract.
  1014. Lee, S. S., Tsai, C. H., Ho, Y. C., and Chang, Y. C. The upregulation of heat shock protein 70 expression in areca quid chewing-associated oral squamous cell carcinomas. Oral Oncol. 2008;44:884-890. View abstract.
  1015. Lee, C. W., Lin, C. C., Luo, S. F., Lee, H. C., Lee, I. T., Aird, W. C., Hwang, T. L., and Yang, C. M. Tumor necrosis factor-alpha enhances neutrophil adhesiveness: induction of vascular cell adhesion molecule-1 via activation of Akt and CaM kinase II and modifications of histone acetyltransferase and histone deacetylase 4 in human tracheal smooth muscle cells. Mol.Pharmacol 2008;73:1454-1464. View abstract.
  1016. Song, W. B., Zhang, Z. S., and Xiao, B. [Protective effect of curcumin against methotrexate-induced small intestinal damage in rats]. Nan.Fang Yi.Ke.Da.Xue.Xue.Bao. 2008;28:119-121. View abstract.
  1017. Wei, S. M., Yan, Z. Z., and Zhou, J. Curcumin attenuates ischemia-reperfusion injury in rat testis. Fertil.Steril. 2009;91:271-277.View abstract.
  1018. Fujiwara, H., Hosokawa, M., Zhou, X., Fujimoto, S., Fukuda, K., Toyoda, K., Nishi, Y., Fujita, Y., Yamada, K., Yamada, Y., Seino, Y., and Inagaki, N. Curcumin inhibits glucose production in isolated mice hepatocytes. Diabetes Res Clin Pract. 2008;80:185-191.View abstract.
  1019. Ji, C., Cao, C., Lu, S., Kivlin, R., Amaral, A., Kouttab, N., Yang, H., Chu, W., Bi, Z., Di, W., and Wan, Y. Curcumin attenuates EGF-induced AQP3 up-regulation and cell migration in human ovarian cancer cells. Cancer Chemother.Pharmacol 2008;62:857-865.View abstract.
  1020. Lee, H. S., Jung, K. K., Cho, J. Y., Rhee, M. H., Hong, S., Kwon, M., Kim, S. H., and Kang, S. Y. Neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation. Pharmazie 2007;62:937-942. View abstract.
  1021. Kim, Y. S., Bahn, K. N., Hah, C. K., Gang, H. I., and Ha, Y. L. Inhibition of 7,12-dimethylbenz[a]anthracene induced mouse skin carcinogenesis by Artemisia capillaris. J Food Sci. 2008;73:T16-T20. View abstract.
  1022. Kadoma, Y. and Fujisawa, S. Comparative radical-scavenging activity of curcumin and tetrahydrocurcumin with thiols as measured by the induction period method. In Vivo 2007;21:979-982. View abstract.
  1023. Lee, M. H., Lin, H. Y., Chen, H. C., and Thomas, J. L. Ultrasound mediates the release of curcumin from microemulsions. Langmuir 3-4-2008;24:1707-1713. View abstract.
  1024. Shukla, P. K., Khanna, V. K., Ali, M. M., Khan, M. Y., and Srimal, R. C. Anti-ischemic effect of curcumin in rat brain. Neurochem.Res 2008;33:1036-1043. View abstract.
  1025. Tikoo, K., Meena, R. L., Kabra, D. G., and Gaikwad, A. B. Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br.J Pharmacol 2008;153:1225-1231. View abstract.
  1026. Billerey-Larmonier, C., Uno, J. K., Larmonier, N., Midura, A. J., Timmermann, B., Ghishan, F. K., and Kiela, P. R. Protective effects of dietary curcumin in mouse model of chemically induced colitis are strain dependent. Inflamm.Bowel.Dis. 2008;14:780-793. View abstract.
  1027. Riemer, C., Burwinkel, M., Schwarz, A., Gultner, S., Mok, S. W., Heise, I., Holtkamp, N., and Baier, M. Evaluation of drugs for treatment of prion infections of the central nervous system. J Gen.Virol. 2008;89(Pt 2):594-597. View abstract.
  1028. Dange, P., Sarma, H., Pandey, B. N., and Mishra, K. P. Radiation-induced incidence of thymic lymphoma in mice and its prevention by antioxidants. J Environ.Pathol.Toxicol Oncol. 2007;26:273-279. View abstract.
  1029. Mishra, S., Karmodiya, K., Surolia, N., and Surolia, A. Synthesis and exploration of novel curcumin analogues as anti-malarial agents. Bioorg.Med.Chem. 3-15-2008;16:2894-2902. View abstract.
  1030. Kutluay, S. B., Doroghazi, J., Roemer, M. E., and Triezenberg, S. J. Curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/CBP histone acetyltransferase activity. Virology 4-10-2008;373:239-247. View abstract.
  1031. Pandey, N., Strider, J., Nolan, W. C., Yan, S. X., and Galvin, J. E. Curcumin inhibits aggregation of alpha-synuclein. Acta Neuropathol. 2008;115:479-489. View abstract.
  1032. Liao, Y. F., Hung, H. C., Hour, T. C., Hsu, P. C., Kao, M. C., Tsay, G. J., and Liu, G. Y. Curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia HL-60 cells. Life Sci. 2-13-2008;82(7-8):367-375. View abstract.
  1033. Steward, W. P. and Gescher, A. J. Curcumin in cancer management: recent results of analogue design and clinical studies and desirable future research. Mol.Nutr.Food Res 2008;52:1005-1009. View abstract.
  1034. Lin, W. N., Luo, S. F., Wu, C. B., Lin, C. C., and Yang, C. M. Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway. Toxicol Appl.Pharmacol 4-15-2008;228:256-268. View abstract.
  1035. Kunwar, A., Barik, A., Mishra, B., Rathinasamy, K., Pandey, R., and Priyadarsini, K. I. Quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells. Biochim.Biophys.Acta 2008;1780:673-679. View abstract.
  1036. Riva, D. A., Fernandez-Larrosa, P. N., Dolcini, G. L., Martinez-Peralta, L. A., Coulombie, F. C., and Mersich, S. E. Two immunomodulators, curcumin and sulfasalazine, enhance IDV antiretroviral activity in HIV-1 persistently infected cells. Arch.Virol. 2008;153:561-565. View abstract.
  1037. Jagatha, B., Mythri, R. B., Vali, S., and Bharath, M. M. Curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for Parkinson's disease explained via in silico studies. Free Radic.Biol.Med. 3-1-2008;44:907-917. View abstract.
  1038. Mathuria, N. and Verma, R. J. Curcumin ameliorates aflatoxin-induced toxicity in mice spermatozoa. Fertil.Steril. 2008;90:775-780. View abstract.
  1039. Lv, B. H., Zhang, L., Zhu, C. C., and Liu, J. [Inhibition of curcumin on histone deacetylase and expression promotion of P21 (WAF1/CIP1) in HepG2 cells]. Zhongguo Zhong.Yao Za Zhi. 2007;32:2051-2055. View abstract.
  1040. Srivastava, R. K., Chen, Q., Siddiqui, I., Sarva, K., and Shankar, S. Linkage of curcumin-induced cell cycle arrest and apoptosis by cyclin-dependent kinase inhibitor p21(/WAF1/CIP1). Cell Cycle 12-1-2007;6:2953-2961. View abstract.
  1041. SCHRAUFSTATTER, E. and BERNT, H. Antibacterial action of curcumin and related compounds. Nature 9-10-1949;164:456. View abstract.
  1042. Kanitkar, M. and Bhonde, R. R. Curcumin treatment enhances islet recovery by induction of heat shock response proteins, Hsp70 and heme oxygenase-1, during cryopreservation. Life Sci. 1-16-2008;82(3-4):182-189. View abstract.
  1043. Lopez-Lazaro, M., Willmore, E., Jobson, A., Gilroy, K. L., Curtis, H., Padget, K., and Austin, C. A. Curcumin induces high levels of topoisomerase I- and II-DNA complexes in K562 leukemia cells. J Nat.Prod. 2007;70:1884-1888. View abstract.
  1044. Srinivasan, K. and Sambaiah, K. The effect of spices on cholesterol 7 alpha-hydroxylase activity and on serum and hepatic cholesterol levels in the rat. Int.J Vitam.Nutr.Res 1991;61:364-369. View abstract.
  1045. Sou, K., Inenaga, S., Takeoka, S., and Tsuchida, E. Loading of curcumin into macrophages using lipid-based nanoparticles. Int.J Pharm 3-20-2008;352(1-2):287-293. View abstract.
  1046. Sivalingam, N., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin attenuates indomethacin-induced oxidative stress and mitochondrial dysfunction. Arch.Toxicol 2008;82:471-481. View abstract.
  1047. Prunotto, M., Bacchetta, M., Jayaraman, S., Galloni, M., Van Eys, G., Gabbiani, G., and Bochaton-Piallat, M. L. Cytostatic drugs differentially affect phenotypic features of porcine coronary artery smooth muscle cell populations. FEBS Lett. 12-22-2007;581:5847-5851. View abstract.
  1048. Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., and Reddy, G. B. Effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat. Med.Sci.Monit. 2007;13:BR286-BR292. View abstract.
  1049. O'Connell, M. A. and Rushworth, S. A. Curcumin: potential for hepatic fibrosis therapy? Br.J Pharmacol 2008;153:403-405. View abstract.
  1050. Pari, L. and Murugan, P. Influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes. Fundam.Clin Pharmacol 2007;21:665-671. View abstract.
  1051. Anuchapreeda, S., Tima, S., Duangrat, C., and Limtrakul, P. Effect of pure curcumin, demethoxycurcumin, and bisdemethoxycurcumin on WT1 gene expression in leukemic cell lines. Cancer Chemother.Pharmacol 2008;62:585-594. View abstract.
  1052. Bishnoi, M., Chopra, K., and Kulkarni, S. K. Protective effect of Curcumin, the active principle of turmeric (Curcuma longa) in haloperidol-induced orofacial dyskinesia and associated behavioural, biochemical and neurochemical changes in rat brain. Pharmacol Biochem.Behav. 2008;88:511-522. View abstract.
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  1055. Farombi, E. O., Shrotriya, S., Na, H. K., Kim, S. H., and Surh, Y. J. Curcumin attenuates dimethylnitrosamine-induced liver injury in rats through Nrf2-mediated induction of heme oxygenase-1. Food Chem.Toxicol 2008;46:1279-1287. View abstract.
  1056. Li, H., van Berlo, D., Shi, T., Speit, G., Knaapen, A. M., Borm, P. J., Albrecht, C., and Schins, R. P. Curcumin protects against cytotoxic and inflammatory effects of quartz particles but causes oxidative DNA damage in a rat lung epithelial cell line. Toxicol Appl.Pharmacol 2-15-2008;227:115-124. View abstract.
  1057. Verschoyle, R. D., Steward, W. P., and Gescher, A. J. Putative cancer chemopreventive agents of dietary origin-how safe are they? Nutr.Cancer 2007;59:152-162. View abstract.
  1058. Bachmeier, B. E., Mohrenz, I. V., Mirisola, V., Schleicher, E., Romeo, F., Hohneke, C., Jochum, M., Nerlich, A. G., and Pfeffer, U. Curcumin downregulates the inflammatory cytokines CXCL1 and -2 in breast cancer cells via NFkappaB. Carcinogenesis 2008;29:779-789. View abstract.
  1059. Anand, P., Kunnumakkara, A. B., Newman, R. A., and Aggarwal, B. B. Bioavailability of curcumin: problems and promises. Mol.Pharm 2007;4:807-818. View abstract.
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  1061. Hafner-Bratkovic, I., Gaspersic, J., Smid, L. M., Bresjanac, M., and Jerala, R. Curcumin binds to the alpha-helical intermediate and to the amyloid form of prion protein - a new mechanism for the inhibition of PrP(Sc) accumulation. J Neurochem. 2008;104:1553-1564. View abstract.
  1062. Pari, L. and Murugan, P. Antihyperlipidemic effect of curcumin and tetrahydrocurcumin in experimental type 2 diabetic rats. Ren Fail. 2007;29:881-889. View abstract.
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  1064. Usta, M., Wortelboer, H. M., Vervoort, J., Boersma, M. G., Rietjens, I. M., van Bladeren, P. J., and Cnubben, N. H. Human glutathione S-transferase-mediated glutathione conjugation of curcumin and efflux of these conjugates in Caco-2 cells. Chem.Res Toxicol 2007;20:1895-1902. View abstract.
  1065. Olszanecki, R., Gebska, A., and Korbut, R. The role of haem oxygenase-1 in the decrease of endothelial intercellular adhesion molecule-1 expression by curcumin. Basic Clin Pharmacol Toxicol 2007;101:411-415. View abstract.
  1066. Safavy, A., Raisch, K. P., Mantena, S., Sanford, L. L., Sham, S. W., Krishna, N. R., and Bonner, J. A. Design and development of water-soluble curcumin conjugates as potential anticancer agents. J Med.Chem. 11-29-2007;50:6284-6288. View abstract.
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  1069. Fukumori, S., Murata, T., Taguchi, M., and Hashimoto, Y. Rapid and drastic induction of CYP3A4 mRNA expression via vitamin D receptor in human intestinal LS180 cells. Drug Metab Pharmacokinet. 2007;22:377-381. View abstract.
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  1071. Sakla, M. S. and Lorson, C. L. Induction of full-length survival motor neuron by polyphenol botanical compounds. Hum.Genet. 2008;122:635-643. View abstract.
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  1074. Ma, Z., Haddadi, A., Molavi, O., Lavasanifar, A., Lai, R., and Samuel, J. Micelles of poly(ethylene oxide)-b-poly(epsilon-caprolactone) as vehicles for the solubilization, stabilization, and controlled delivery of curcumin. J Biomed.Mater.Res A 2008;86:300-310. View abstract.
  1075. Rathore, P., Dohare, P., Varma, S., Ray, A., Sharma, U., Jagannathan, N. R., and Ray, M. Curcuma oil: reduces early accumulation of oxidative product and is anti-apoptogenic in transient focal ischemia in rat brain. Neurochem.Res 2008;33:1672-1682. View abstract.
  1076. Rai, D., Singh, J. K., Roy, N., and Panda, D. Curcumin inhibits FtsZ assembly: an attractive mechanism for its antibacterial activity. Biochem.J 2-15-2008;410:147-155. View abstract.
  1077. Baum, L., Cheung, S. K., Mok, V. C., Lam, L. C., Leung, V. P., Hui, E., Ng, C. C., Chow, M., Ho, P. C., Lam, S., Woo, J., Chiu, H. F., Goggins, W., Zee, B., Wong, A., Mok, H., Cheng, W. K., Fong, C., Lee, J. S., Chan, M. H., Szeto, S. S., Lui, V. W., Tsoh, J., Kwok, T. C., Chan, I. H., and Lam, C. W. Curcumin effects on blood lipid profile in a 6-month human study. Pharmacol Res 2007;56:509-514.View abstract.
  1078. El Banhawey, M. A., Ashry, M. A., El Ansary, A. K., and Aly, S. A. Effect of Curcuma longa or parziquantel on Schistosoma mansoni infected mice liver--histological and histochemical study. Indian J Exp.Biol. 2007;45:877-889. View abstract.
  1079. Wang, R., Xu, Y., Wu, H. L., Li, Y. B., Li, Y. H., Guo, J. B., and Li, X. J. The antidepressant effects of curcumin in the forced swimming test involve 5-HT1 and 5-HT2 receptors. Eur.J Pharmacol 1-6-2008;578:43-50. View abstract.
  1080. Raza, H., John, A., Brown, E. M., Benedict, S., and Kambal, A. Alterations in mitochondrial respiratory functions, redox metabolism and apoptosis by oxidant 4-hydroxynonenal and antioxidants curcumin and melatonin in PC12 cells. Toxicol Appl.Pharmacol 1-15-2008;226:161-168. View abstract.
  1081. Chen, Y., Shu, W., Chen, W., Wu, Q., Liu, H., and Cui, G. Curcumin, both histone deacetylase and p300/CBP-specific inhibitor, represses the activity of nuclear factor kappa B and Notch 1 in Raji cells. Basic Clin Pharmacol Toxicol 2007;101:427-433. View abstract.
  1082. Tomida, M., Ohtake, H., Yokota, T., Kobayashi, Y., and Kurosumi, M. Stat3 up-regulates expression of nicotinamide N-methyltransferase in human cancer cells. J Cancer Res Clin Oncol. 2008;134:551-559. View abstract.
  1083. Paramasivam, S., Thangaradjou, T., and Kannan, L. Effect of natural preservatives on the growth of histamine producing bacteria. J Environ.Biol. 2007;28:271-274. View abstract.
  1084. Mattson, M. P. Dietary factors, hormesis and health. Ageing Res Rev. 2008;7:43-48. View abstract.
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  1086. Meghana, K., Sanjeev, G., and Ramesh, B. Curcumin prevents streptozotocin-induced islet damage by scavenging free radicals: a prophylactic and protective role. Eur.J Pharmacol 12-22-2007;577(1-3):183-191. View abstract.
  1087. Gal, S., Lichtenberg, D., Bor, A., and Pinchuk, I. Copper-induced peroxidation of phosphatidylserine-containing liposomes is inhibited by nanomolar concentrations of specific antioxidants. Chem.Phys.Lipids 2007;150:186-203. View abstract.
  1088. Goel, A., Kunnumakkara, A. B., and Aggarwal, B. B. Curcumin as "Curecumin": from kitchen to clinic. Biochem Pharmacol 2-15-2008;75:787-809. View abstract.
  1089. Kumar, A., Naidu, P. S., Seghal, N., and Padi, S. S. Effect of curcumin on intracerebroventricular colchicine-induced cognitive impairment and oxidative stress in rats. J Med.Food 2007;10:486-494. View abstract.
  1090. Marin, Y. E., Wall, B. A., Wang, S., Namkoong, J., Martino, J. J., Suh, J., Lee, H. J., Rabson, A. B., Yang, C. S., Chen, S., and Ryu, J. H. Curcumin downregulates the constitutive activity of NF-kappaB and induces apoptosis in novel mouse melanoma cells. Melanoma Res 2007;17:274-283. View abstract.
  1091. Jin, C. Y., Lee, J. D., Park, C., Choi, Y. H., and Kim, G. Y. Curcumin attenuates the release of pro-inflammatory cytokines in lipopolysaccharide-stimulated BV2 microglia. Acta Pharmacol Sin. 2007;28:1645-1651. View abstract.
  1092. Thavara, U., Tawatsin, A., Bhakdeenuan, P., Wongsinkongman, P., Boonruad, T., Bansiddhi, J., Chavalittumrong, P., Komalamisra, N., Siriyasatien, P., and Mulla, M. S. Repellent activity of essential oils against cockroaches (Dictyoptera: Blattidae, Blattellidae, and Blaberidae) in Thailand. Southeast Asian J Trop.Med.Public Health 2007;38:663-673. View abstract.
  1093. Zhang, X. C., Chen, J., Su, C. H., Yang, H. Y., and Lee, M. H. Roles for CSN5 in control of p53/MDM2 activities. J Cell Biochem. 3-1-2008;103:1219-1230. View abstract.
  1094. Jagota, A. and Reddy, M. Y. The effect of curcumin on ethanol induced changes in suprachiasmatic nucleus (SCN) and pineal. Cell Mol.Neurobiol. 2007;27:997-1006. View abstract.
  1095. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on hepatic and renal functional markers and protein levels in experimental type 2 diabetic rats. Basic Clin Pharmacol Toxicol 2007;101:241-245. View abstract.
  1096. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Effects of manganese complexes of curcumin and diacetylcurcumin on kainic acid-induced neurotoxic responses in the rat hippocampus. Biol.Pharm Bull. 2007;30:1732-1739. View abstract.
  1097. Manjunatha, H. and Srinivasan, K. Hypolipidemic and antioxidant effects of curcumin and capsaicin in high-fat-fed rats. Can J Physiol Pharmacol 2007;85:588-596. View abstract.
  1098. Kuhad, A. and Chopra, K. Curcumin attenuates diabetic encephalopathy in rats: behavioral and biochemical evidences. Eur.J Pharmacol 12-8-2007;576(1-3):34-42. View abstract.
  1099. Shinojima, N., Yokoyama, T., Kondo, Y., and Kondo, S. Roles of the Akt/mTOR/p70S6K and ERK1/2 signaling pathways in curcumin-induced autophagy. Autophagy. 2007;3:635-637. View abstract.
  1100. Kurien, B. T., Singh, A., Matsumoto, H., and Scofield, R. H. Improving the solubility and pharmacological efficacy of curcumin by heat treatment. Assay.Drug Dev.Technol. 2007;5:567-576. View abstract.
  1101. Hsu, Y. C., Weng, H. C., Lin, S., and Chien, Y. W. Curcuminoids-cellular uptake by human primary colon cancer cells as quantitated by a sensitive HPLC assay and its relation with the inhibition of proliferation and apoptosis. J Agric.Food Chem. 10-3-2007;55:8213-8222. View abstract.
  1102. Takahashi, M., Ishiko, T., Kamohara, H., Hidaka, H., Ikeda, O., Ogawa, M., and Baba, H. Curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) blocks the chemotaxis of neutrophils by inhibiting signal transduction through IL-8 receptors. Mediators.Inflamm. 2007;2007:10767. View abstract.
  1103. Liu, B., Bai, Q. X., Chen, X. Q., Gao, G. X., and Gu, H. T. [Effect of curcumin on expression of survivin, Bcl-2 and Bax in human multiple myeloma cell line]. Zhongguo Shi Yan.Xue.Ye.Xue.Za Zhi. 2007;15:762-766. View abstract.
  1104. Franck, T., Kohnen, S., Grulke, S., Neven, P., Goutman, Y., Peters, F., Pirotte, B., Deby-Dupont, G., and Serteyn, D. Inhibitory effect of curcuminoids and tetrahydrocurcuminoids on equine activated neutrophils and myeloperoxidase activity. Physiol Res 2008;57:577-587. View abstract.
  1105. Ingolfsson, H. I., Koeppe, R. E., and Andersen, O. S. Curcumin is a modulator of bilayer material properties. Biochemistry 9-11-2007;46:10384-10391. View abstract.
  1106. Khajavi, M., Shiga, K., Wiszniewski, W., He, F., Shaw, C. A., Yan, J., Wensel, T. G., Snipes, G. J., and Lupski, J. R. Oral curcumin mitigates the clinical and neuropathologic phenotype of the Trembler-J mouse: a potential therapy for inherited neuropathy. Am.J Hum.Genet. 2007;81:438-453. View abstract.
  1107. Takahashi, M., Inafuku, K., Miyagi, T., Oku, H., Wada, K., Imura, T., and Kitamoto, D. Efficient preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method. J Oleo.Sci. 2006;56:35-42. View abstract.
  1108. Murugan, P. and Pari, L. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats. J Ethnopharmacol. 9-25-2007;113:479-486. View abstract.
  1109. Park, C., Moon, D. O., Choi, I. W., Choi, B. T., Nam, T. J., Rhu, C. H., Kwon, T. K., Lee, W. H., Kim, G. Y., and Choi, Y. H. Curcumin induces apoptosis and inhibits prostaglandin E production in synovial fibroblasts of patients with rheumatoid arthritis. Int.J Mol.Med. 2007;20:365-372. View abstract.
  1110. Poma, P., Notarbartolo, M., Labbozzetta, M., Maurici, A., Carina, V., Alaimo, A., Rizzi, M., Simoni, D., and D'Alessandro, N. The antitumor activities of curcumin and of its isoxazole analogue are not affected by multiple gene expression changes in an MDR model of the MCF-7 breast cancer cell line: analysis of the possible molecular basis. Int.J Mol.Med. 2007;20:329-335. View abstract.
  1111. Kim, Y. S., Ahn, Y., Hong, M. H., Joo, S. Y., Kim, K. H., Sohn, I. S., Park, H. W., Hong, Y. J., Kim, J. H., Kim, W., Jeong, M. H., Cho, J. G., Park, J. C., and Kang, J. C. Curcumin attenuates inflammatory responses of TNF-alpha-stimulated human endothelial cells. J Cardiovasc.Pharmacol 2007;50:41-49. View abstract.
  1112. Mathuria, N. and Verma, R. J. Aflatoxin induced hemolysis and its amelioration by turmeric extracts and curcumin in vitro. Acta Pol.Pharm 2007;64:165-168. View abstract.
  1113. Wen, C. C., Kuo, Y. H., Jan, J. T., Liang, P. H., Wang, S. Y., Liu, H. G., Lee, C. K., Chang, S. T., Kuo, C. J., Lee, S. S., Hou, C. C., Hsiao, P. W., Chien, S. C., Shyur, L. F., and Yang, N. S. Specific plant terpenoids and lignoids possess potent antiviral activities against severe acute respiratory syndrome coronavirus. J Med.Chem. 8-23-2007;50:4087-4095. View abstract.
  1114. Mrudula, T., Suryanarayana, P., Srinivas, P. N., and Reddy, G. B. Effect of curcumin on hyperglycemia-induced vascular endothelial growth factor expression in streptozotocin-induced diabetic rat retina. Biochem.Biophys.Res Commun. 9-21-2007;361:528-532.View abstract.
  1115. Mandel, S., Amit, T., Bar-Am, O., and Youdim, M. B. Iron dysregulation in Alzheimer's disease: multimodal brain permeable iron chelating drugs, possessing neuroprotective-neurorescue and amyloid precursor protein-processing regulatory activities as therapeutic agents. Prog.Neurobiol. 2007;82:348-360. View abstract.
  1116. Han, G., Liu, Z. M., Wang, X. Y., and Wang, Y. N. [Study on effect of different extracts in curcuma long on stability of curcumin]. Zhongguo Zhong.Yao Za Zhi. 2007;32:915-917. View abstract.
  1117. Fiala, M., Liu, P. T., Espinosa-Jeffrey, A., Rosenthal, M. J., Bernard, G., Ringman, J. M., Sayre, J., Zhang, L., Zaghi, J., Dejbakhsh, S., Chiang, B., Hui, J., Mahanian, M., Baghaee, A., Hong, P., and Cashman, J. Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. Proc.Natl.Acad.Sci.U.S A 7-31-2007;104:12849-12854. View abstract.
  1118. Hammamieh, R., Sumaida, D., Zhang, X., Das, R., and Jett, M. Control of the growth of human breast cancer cells in culture by manipulation of arachidonate metabolism. BMC.Cancer 2007;7:138. View abstract.
  1119. Pari, L. and Murugan, P. Tetrahydrocurcumin prevents brain lipid peroxidation in streptozotocin-induced diabetic rats. J Med.Food 2007;10:323-329. View abstract.
  1120. Cheng, Y., Ping, J., and Liu, C. [Effect of curcumin on activity of matrix metalloproteinase 2, 9 and nuclear expression of RelA in rat hepatic stellate cells by activating peroxisome proliferator-activated receptor gamma signal]. Zhongguo Zhong.Xi.Yi.Jie.He.Za Zhi. 2007;27:439-443. View abstract.
  1121. Sandur, S. K., Ichikawa, H., Pandey, M. K., Kunnumakkara, A. B., Sung, B., Sethi, G., and Aggarwal, B. B. Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane). Free Radic.Biol.Med. 8-15-2007;43:568-580. View abstract.
  1122. Kang, E. S., Woo, I. S., Kim, H. J., Eun, S. Y., Paek, K. S., Kim, H. J., Chang, K. C., Lee, J. H., Lee, H. T., Kim, J. H., Nishinaka, T., Yabe-Nishimura, C., and Seo, H. G. Up-regulation of aldose reductase expression mediated by phosphatidylinositol 3-kinase/Akt and Nrf2 is involved in the protective effect of curcumin against oxidative damage. Free Radic.Biol.Med. 8-15-2007;43:535-545.View abstract.
  1123. Martelli, L., Ragazzi, E., di Mario, F., Martelli, M., Castagliuolo, I., Dal Maschio, M., Palu, G., Maschietto, M., Scorzeto, M., Vassanelli, S., and Brun, P. A potential role for the vanilloid receptor TRPV1 in the therapeutic effect of curcumin in dinitrobenzene sulphonic acid-induced colitis in mice. Neurogastroenterol.Motil. 2007;19:668-674. View abstract.
  1124. Walle, T. and Walle, U. K. Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells. J Pharm Pharmacol 2007;59:857-862. View abstract.
  1125. Ye, S. F., Hou, Z. Q., Zhong, L. M., and Zhang, Q. Q. Effect of curcumin on the induction of glutathione S-transferases and NADP(H):quinone oxidoreductase and its possible mechanism of action. Yao Xue.Xue.Bao. 2007;42:376-380. View abstract.
  1126. Hoehle, S. I., Pfeiffer, E., and Metzler, M. Glucuronidation of curcuminoids by human microsomal and recombinant UDP-glucuronosyltransferases. Mol.Nutr.Food Res 2007;51:932-938. View abstract.
  1127. Xu, Y., Ku, B., Cui, L., Li, X., Barish, P. A., Foster, T. C., and Ogle, W. O. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 8-8-2007;1162:9-18. View abstract.
  1128. Salmaso, S., Bersani, S., Semenzato, A., and Caliceti, P. New cyclodextrin bioconjugates for active tumour targeting. J Drug Target 2007;15:379-390. View abstract.
  1129. Ragunathan, I. and Panneerselvam, N. Antimutagenic potential of curcumin on chromosomal aberrations in Allium cepa. J Zhejiang.Univ Sci.B 2007;8:470-475. View abstract.
  1130. Huang, X. R., Qi, M. X., Wu, Z. Z., Yan, J., and Hu, Y. H. [Effect of Rhizoma Curcumae and arsenite trioxide on proliferation and signal transduction molecule of lens epithelial cell]. Zhongguo Zhong.Yao Za Zhi. 2007;32:725-728. View abstract.
  1131. Pae, H. O., Jeong, G. S., Jeong, S. O., Kim, H. S., Kim, S. A., Kim, Y. C., Yoo, S. J., Kim, H. D., and Chung, H. T. Roles of heme oxygenase-1 in curcumin-induced growth inhibition in rat smooth muscle cells. Exp.Mol.Med. 6-30-2007;39:267-277. View abstract.
  1132. Zheng, S., Yumei, F., and Chen, A. De novo synthesis of glutathione is a prerequisite for curcumin to inhibit hepatic stellate cell (HSC) activation. Free Radic.Biol.Med. 8-1-2007;43:444-453. View abstract.
  1133. Dhandapani, K. M., Mahesh, V. B., and Brann, D. W. Curcumin suppresses growth and chemoresistance of human glioblastoma cells via AP-1 and NFkappaB transcription factors. J Neurochem. 2007;102:522-538. View abstract.
  1134. Liu, E., Wu, J., Cao, W., Zhang, J., Liu, W., Jiang, X., and Zhang, X. Curcumin induces G2/M cell cycle arrest in a p53-dependent manner and upregulates ING4 expression in human glioma. J Neurooncol. 2007;85:263-270. View abstract.
  1135. Jain, V., Prasad, V., Pal, R., and Singh, S. Standardization and stability studies of neuroprotective lipid soluble fraction obtained from Curcuma longa. J Pharm Biomed.Anal. 9-3-2007;44:1079-1086. View abstract.
  1136. Yu, Z. and Shah, D. M. Curcumin down-regulates Ets-1 and Bcl-2 expression in human endometrial carcinoma HEC-1-A cells. Gynecol.Oncol. 2007;106:541-548. View abstract.
  1137. Adhvaryu, M. R., Reddy, N., and Parabia, M. H. Effects of four Indian medicinal herbs on Isoniazid-, Rifampicin- and Pyrazinamide-induced hepatic injury and immunosuppression in guinea pigs. World J Gastroenterol. 6-21-2007;13:3199-3205. View abstract.
  1138. Cheng, Y., Kozubek, A., Ohlsson, L., Sternby, B., and Duan, R. D. Curcumin decreases acid sphingomyelinase activity in colon cancer Caco-2 cells. Planta Med. 2007;73:725-730. View abstract.
  1139. Kim, S. J. and Hellerstein, M. K. Pharmacological doses of dietary curcumin increase colon epithelial cell proliferation in vivo in rats. Phytother.Res 2007;21:995-998. View abstract.
  1140. Zhang, D. P., Qiu, H., Zhuang, Y., and Meng, F. Q. [The effect of curcumin on bleomycin-induced pulmonary fibrosis in rats]. Zhonghua Jie.He.He.Hu Xi.Za Zhi. 2007;30:197-201. View abstract.
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  1143. Bright, J. J. Curcumin and autoimmune disease. Adv.Exp.Med.Biol. 2007;595:425-451. View abstract.
  1144. Venkatesan, N., Punithavathi, D., and Babu, M. Protection from acute and chronic lung diseases by curcumin. Adv.Exp.Med.Biol. 2007;595:379-405. View abstract.
  1145. Miriyala, S., Panchatcharam, M., and Rengarajulu, P. Cardioprotective effects of curcumin. Adv.Exp.Med.Biol. 2007;595:359-377.View abstract.
  1146. Thangapazham, R. L., Sharma, A., and Maheshwari, R. K. Beneficial role of curcumin in skin diseases. Adv.Exp.Med.Biol. 2007;595:343-357. View abstract.
  1147. Gautam, S. C., Gao, X., and Dulchavsky, S. Immunomodulation by curcumin. Adv.Exp.Med.Biol. 2007;595:321-341. View abstract.
  1148. Jagetia, G. C. Radioprotection and radiosensitization by curcumin. Adv.Exp.Med.Biol. 2007;595:301-320. View abstract.
  1149. Rao, C. V. Regulation of COX and LOX by curcumin. Adv.Exp.Med.Biol. 2007;595:213-226. View abstract.
  1150. Cole, G. M., Teter, B., and Frautschy, S. A. Neuroprotective effects of curcumin. Adv.Exp.Med.Biol. 2007;595:197-212. View abstract.
  1151. Bhandarkar, S. S. and Arbiser, J. L. Curcumin as an inhibitor of angiogenesis. Adv.Exp.Med.Biol. 2007;595:185-195. View abstract.
  1152. Kuttan, G., Kumar, K. B., Guruvayoorappan, C., and Kuttan, R. Antitumor, anti-invasion, and antimetastatic effects of curcumin. Adv.Exp.Med.Biol. 2007;595:173-184. View abstract.
  1153. Shishodia, S., Singh, T., and Chaturvedi, M. M. Modulation of transcription factors by curcumin. Adv.Exp.Med.Biol. 2007;595:127-148. View abstract.
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  1173. Moss, A. C. Curcumin for maintenance therapy in ulcerative colitis. Clin Gastroenterol.Hepatol. 2007;5:642. View abstract.
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  1175. Juan, H., Terhaag, B., Cong, Z., Bi-Kui, Z., Rong-Hua, Z., Feng, W., Fen-Li, S., Juan, S., Jing, T., and Wen-Xing, P. Unexpected effect of concomitantly administered curcumin on the pharmacokinetics of talinolol in healthy Chinese volunteers. Eur.J Clin Pharmacol 2007;63:663-668. View abstract.
  1176. Hauser, P. J., Han, Z., Sindhwani, P., and Hurst, R. E. Sensitivity of bladder cancer cells to curcumin and its derivatives depends on the extracellular matrix. Anticancer Res 2007;27:737-740. View abstract.
  1177. Abuarqoub, H., Green, C. J., Foresti, R., and Motterlini, R. Curcumin reduces cold storage-induced damage in human cardiac myoblasts. Exp.Mol.Med. 4-30-2007;39:139-148. View abstract.
  1178. Shen, S. Q., Zhang, Y., Xiang, J. J., and Xiong, C. L. Protective effect of curcumin against liver warm ischemia/reperfusion injury in rat model is associated with regulation of heat shock protein and antioxidant enzymes. World J Gastroenterol. 4-7-2007;13:1953-1961. View abstract.
  1179. Xu, P. H., Long, Y., Dai, F., and Liu, Z. L. The relaxant effect of curcumin on porcine coronary arterial ring segments. Vascul.Pharmacol 2007;47:25-30. View abstract.
  1180. Bisht, S., Feldmann, G., Soni, S., Ravi, R., Karikar, C., Maitra, A., and Maitra, A. Polymeric nanoparticle-encapsulated curcumin ("nanocurcumin"): a novel strategy for human cancer therapy. J Nanobiotechnology. 2007;5:3. View abstract.
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  1182. Kowluru, R. A. and Kanwar, M. Effects of curcumin on retinal oxidative stress and inflammation in diabetes. Nutr.Metab (Lond) 2007;4:8. View abstract.
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  1184. Smith, D. G., Cappai, R., and Barnham, K. J. The redox chemistry of the Alzheimer's disease amyloid beta peptide. Biochim.Biophys.Acta 2007;1768:1976-1990. View abstract.
  1185. Deguchi, Y., Andoh, A., Inatomi, O., Yagi, Y., Bamba, S., Araki, Y., Hata, K., Tsujikawa, T., and Fujiyama, Y. Curcumin prevents the development of dextran sulfate Sodium (DSS)-induced experimental colitis. Dig.Dis.Sci. 2007;52:2993-2998. View abstract.
  1186. Neuss, H., Huang, X., Hetfeld, B. K., Deva, R., Henklein, P., Nigam, S., Mall, J. W., Schwenk, W., and Dubiel, W. The ubiquitin- and proteasome-dependent degradation of COX-2 is regulated by the COP9 signalosome and differentially influenced by coxibs. J Mol.Med. 2007;85:961-970. View abstract.
  1187. Eguchi, A., Kaneko, Y., Murakami, A., and Ohigashi, H. Zerumbone suppresses phorbol ester-induced expression of multiple scavenger receptor genes in THP-1 human monocytic cells. Biosci.Biotechnol.Biochem. 2007;71:935-945. View abstract.
  1188. Kiso, Y., Suzuki, Y., Watanabe, N., Oshima, Y., and Hikino, H. Antihepatotoxic Principles of Curcuma longa Rhizomes1. Planta Med. 1983;49:185-187. View abstract.
  1189. Yang, K. Y., Lin, L. C., Tseng, T. Y., Wang, S. C., and Tsai, T. H. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 6-15-2007;853(1-2):183-189. View abstract.
  1190. Bhattacharyya, S., Mandal, D., Saha, B., Sen, G. S., Das, T., and Sa, G. Curcumin prevents tumor-induced T cell apoptosis through Stat-5a-mediated Bcl-2 induction. J Biol.Chem. 6-1-2007;282:15954-15964. View abstract.
  1191. Reyes-Gordillo, K., Segovia, J., Shibayama, M., Vergara, P., Moreno, M. G., and Muriel, P. Curcumin protects against acute liver damage in the rat by inhibiting NF-kappaB, proinflammatory cytokines production and oxidative stress. Biochim.Biophys.Acta 2007;1770:989-996. View abstract.
  1192. Best, L., Elliott, A. C., and Brown, P. D. Curcumin induces electrical activity in rat pancreatic beta-cells by activating the volume-regulated anion channel. Biochem.Pharmacol 6-1-2007;73:1768-1775. View abstract.
  1193. Shih, P. C., Lee, H. H., Lai, S. C., Chen, K. M., Jiang, S. T., Chen, Y. F., and Shiow, S. J. Efficacy of curcumin therapy against Angiostrongylus cantonensis-induced eosinophilic meningitis. J Helminthol. 2007;81:1-5. View abstract.
  1194. Venkataranganna, M. V., Rafiq, M., Gopumadhavan, S., Peer, G., Babu, U. V., and Mitra, S. K. NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene- induced colitis through down-regulation of NFkappa-B and iNOS. World J Gastroenterol. 2-21-2007;13:1103-1107. View abstract.
  1195. Zhou, Y., Zheng, S., Lin, J., Zhang, Q. J., and Chen, A. The interruption of the PDGF and EGF signaling pathways by curcumin stimulates gene expression of PPARgamma in rat activated hepatic stellate cell in vitro. Lab Invest 2007;87:488-498. View abstract.
  1196. Lian, Q., Li, X., Shang, Y., Yao, S., Ma, L., and Jin, S. Protective effect of curcumin on endotoxin-induced acute lung injury in rats. J Huazhong.Univ Sci.Technolog.Med.Sci. 2006;26:678-681. View abstract.
  1197. Bruck, R., Ashkenazi, M., Weiss, S., Goldiner, I., Shapiro, H., Aeed, H., Genina, O., Helpern, Z., and Pines, M. Prevention of liver cirrhosis in rats by curcumin. Liver Int. 2007;27:373-383. View abstract.
  1198. Atsumi, T., Tonosaki, K., and Fujisawa, S. Comparative cytotoxicity and ROS generation by curcumin and tetrahydrocurcumin following visible-light irradiation or treatment with horseradish peroxidase. Anticancer Res 2007;27(1A):363-371. View abstract.
  1199. Sivalingam, N., Hanumantharaya, R., Faith, M., Basivireddy, J., Balasubramanian, K. A., and Jacob, M. Curcumin reduces indomethacin-induced damage in the rat small intestine. J Appl.Toxicol 2007;27:551-560. View abstract.
  1200. Wagner, H., Wierer, M., and Bauer, R. [In vitro Inhibition of Prostaglandin Biosynthesis by Essential Oils and Phenolic Compounds1.]. Planta Med. 1986;52:184-187. View abstract.
  1201. Kumar, P., Padi, S. S., Naidu, P. S., and Kumar, A. Possible neuroprotective mechanisms of curcumin in attenuating 3-nitropropionic acid-induced neurotoxicity. Methods Find.Exp.Clin Pharmacol 2007;29:19-25. View abstract.
  1202. Mitra, A., Chakrabarti, J., Banerji, A., Chatterjee, A., and Das, B. R. Curcumin, a potential inhibitor of MMP-2 in human laryngeal squamous carcinoma cells HEp2. J Environ.Pathol.Toxicol Oncol. 2006;25:679-690. View abstract.
  1203. Ma, Z., Shayeganpour, A., Brocks, D. R., Lavasanifar, A., and Samuel, J. High-performance liquid chromatography analysis of curcumin in rat plasma: application to pharmacokinetics of polymeric micellar formulation of curcumin. Biomed.Chromatogr. 2007;21:546-552. View abstract.
  1204. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on plasma antioxidants in streptozotocin-nicotinamide experimental diabetes. J Basic Clin Physiol Pharmacol 2006;17:231-244. View abstract.
  1205. Davis, J. M., Murphy, E. A., Carmichael, M. D., Zielinski, M. R., Groschwitz, C. M., Brown, A. S., Gangemi, J. D., Ghaffar, A., and Mayer, E. P. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am.J Physiol Regul.Integr.Comp Physiol 2007;292:R2168-R2173. View abstract.
  1206. Pan, C. J., Shao, Z. Y., Tang, J. J., Wang, J., and Huang, N. In vitro studies of platelet adhesion, activation, and protein adsorption on curcumin-eluting biodegradable stent materials. J Biomed.Mater.Res A 9-1-2007;82:740-746. View abstract.
  1207. Srinivas, L., Shalini, V. K., and Shylaja, M. Turmerin: a water soluble antioxidant peptide from turmeric [Curcuma longa]. Arch.Biochem.Biophys. 2-1-1992;292:617-623. View abstract.
  1208. Bentzen, P. J., Lang, E., and Lang, F. Curcumin induced suicidal erythrocyte death. Cell Physiol Biochem. 2007;19(1-4):153-164.View abstract.
  1209. Deng, J., Grande, F., and Neamati, N. Small molecule inhibitors of Stat3 signaling pathway. Curr.Cancer Drug Targets. 2007;7:91-107. View abstract.
  1210. Kalpana, C., Sudheer, A. R., Rajasekharan, K. N., and Menon, V. P. Comparative effects of curcumin and its synthetic analogue on tissue lipid peroxidation and antioxidant status during nicotine-induced toxicity. Singapore Med.J 2007;48:124-130. View abstract.
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  1212. Zhang, H. N., Yu, C. X., Zhang, P. J., Chen, W. W., Jiang, A. L., Kong, F., Deng, J. T., Zhang, J. Y., and Young, C. Y. Curcumin downregulates homeobox gene NKX3.1 in prostate cancer cell LNCaP. Acta Pharmacol Sin. 2007;28:423-430. View abstract.
  1213. Shin, H. J., Lee, J. Y., Son, E., Lee, D. H., Kim, H. J., Kang, S. S., Cho, G. J., Choi, W. S., and Roh, G. S. Curcumin attenuates the kainic acid-induced hippocampal cell death in the mice. Neurosci.Lett. 4-6-2007;416:49-54. View abstract.
  1214. Lin, C. C., Lee, C. W., Chu, T. H., Cheng, C. Y., Luo, S. F., Hsiao, L. D., and Yang, C. M. Transactivation of Src, PDGF receptor, and Akt is involved in IL-1beta-induced ICAM-1 expression in A549 cells. J Cell Physiol 2007;211:771-780. View abstract.
  1215. Tomren, M. A., Masson, M., Loftsson, T., and Tonnesen, H. H. Studies on curcumin and curcuminoids XXXI. Symmetric and asymmetric curcuminoids: stability, activity and complexation with cyclodextrin. Int.J Pharm 6-29-2007;338(1-2):27-34. View abstract.
  1216. Shakibaei, M., John, T., Schulze-Tanzil, G., Lehmann, I., and Mobasheri, A. Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment of osteoarthritis. Biochem.Pharmacol 5-1-2007;73:1434-1445. View abstract.
  1217. Shi, P., Chen, W. W., Hu, X. Y., Yu, C. X., Zhang, P. J., Jiang, A. L., and Zhang, J. Y. [Up-regulates the expression of maspin gene in prostate cancer cell line LNCaP]. Yao Xue.Xue.Bao. 2006;41:1152-1156. View abstract.
  1218. Camacho-Barquero, L., Villegas, I., Sanchez-Calvo, J. M., Talero, E., Sanchez-Fidalgo, S., Motilva, V., and Alarcon, de la Lastra. Curcumin, a Curcuma longa constituent, acts on MAPK p38 pathway modulating COX-2 and iNOS expression in chronic experimental colitis. Int.Immunopharmacol. 2007;7:333-342. View abstract.
  1219. Calabrese, V., Guagliano, E., Sapienza, M., Mancuso, C., Butterfield, D. A., and Stella, A. M. Redox regulation of cellular stress response in neurodegenerative disorders. Ital.J Biochem. 2006;55(3-4):263-282. View abstract.
  1220. Cho, J. W., Lee, K. S., and Kim, C. W. Curcumin attenuates the expression of IL-1beta, IL-6, and TNF-alpha as well as cyclin E in TNF-alpha-treated HaCaT cells; NF-kappaB and MAPKs as potential upstream targets. Int.J Mol.Med. 2007;19:469-474. View abstract.
  1221. Byeon, S. R., Lee, J. H., Sohn, J. H., Kim, D. C., Shin, K. J., Yoo, K. H., Mook-Jung, I., Lee, W. K., and Kim, D. J. Bis-styrylpyridine and bis-styrylbenzene derivatives as inhibitors for Abeta fibril formation. Bioorg.Med.Chem.Lett. 3-1-2007;17:1466-1470. View abstract.
  1222. Dairam, A., Limson, J. L., Watkins, G. M., Antunes, E., and Daya, S. Curcuminoids, curcumin, and demethoxycurcumin reduce lead-induced memory deficits in male Wistar rats. J Agric.Food Chem. 2-7-2007;55:1039-1044. View abstract.
  1223. Kurup, V. P., Barrios, C. S., Raju, R., Johnson, B. D., Levy, M. B., and Fink, J. N. Immune response modulation by curcumin in a latex allergy model. Clin Mol.Allergy 2007;5:1. View abstract.
  1224. Jung, Y., Xu, W., Kim, H., Ha, N., and Neckers, L. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochim.Biophys.Acta 2007;1773:383-390. View abstract.
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  1226. Pari, L. and Murugan, P. Changes in glycoprotein components in streptozotocin--nicotinamide induced type 2 diabetes: influence of tetrahydrocurcumin from Curcuma longa. Plant Foods Hum.Nutr. 2007;62:25-29. View abstract.
  1227. Chen, C. C., Taniguchi, T., and D'Andrea, A. The Fanconi anemia (FA) pathway confers glioma resistance to DNA alkylating agents. J Mol.Med. 2007;85:497-509. View abstract.
  1228. Farombi, E. O., Abarikwu, S. O., Adedara, I. A., and Oyeyemi, M. O. Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats. Basic Clin Pharmacol Toxicol 2007;100:43-48. View abstract.
  1229. Jagetia, G. C. and Aggarwal, B. B. "Spicing up" of the immune system by curcumin. J Clin Immunol. 2007;27:19-35. View abstract.
  1230. Somparn, P., Phisalaphong, C., Nakornchai, S., Unchern, S., and Morales, N. P. Comparative antioxidant activities of curcumin and its demethoxy and hydrogenated derivatives. Biol.Pharm Bull. 2007;30:74-78. View abstract.
  1231. Calabrese, V., Guagliano, E., Sapienza, M., Panebianco, M., Calafato, S., Puleo, E., Pennisi, G., Mancuso, C., Butterfield, D. A., and Stella, A. G. Redox regulation of cellular stress response in aging and neurodegenerative disorders: role of vitagenes. Neurochem.Res 2007;32(4-5):757-773. View abstract.
  1232. Kwon, Y. and Magnuson, B. A. Effect of azoxymethane and curcumin on transcriptional levels of cyclooxygenase-1 and -2 during initiation of colon carcinogenesis. Scand.J Gastroenterol. 2007;42:72-80. View abstract.
  1233. Zhang, K. Z., Xu, J. H., Huang, X. W., Wu, L. X., Su, Y., and Chen, Y. Z. Curcumin synergistically augments bcr/abl phosphorothioate antisense oligonucleotides to inhibit growth of chronic myelogenous leukemia cells. Acta Pharmacol Sin. 2007;28:105-110. View abstract.
  1234. Mythri, R. B., Jagatha, B., Pradhan, N., Andersen, J., and Bharath, M. M. Mitochondrial complex I inhibition in Parkinson's disease: how can curcumin protect mitochondria? Antioxid.Redox.Signal. 2007;9:399-408. View abstract.
  1235. Gururajan, M., Dasu, T., Shahidain, S., Jennings, C. D., Robertson, D. A., Rangnekar, V. M., and Bondada, S. Spleen tyrosine kinase (Syk), a novel target of curcumin, is required for B lymphoma growth. J Immunol. 1-1-2007;178:111-121. View abstract.
  1236. Pinilla, F. G. The impact of diet and exercise on brain plasticity and disease. Nutr.Health 2006;18:277-284. View abstract.
  1237. Sharma, S., Chopra, K., Kulkarni, S. K., and Agrewala, J. N. Resveratrol and curcumin suppress immune response through CD28/CTLA-4 and CD80 co-stimulatory pathway. Clin Exp.Immunol. 2007;147:155-163. View abstract.
  1238. Mishra, S., Mishra, J. P., and Kumar, A. Activation of JNK-dependent pathway is required for HIV viral protein R-induced apoptosis in human monocytic cells: involvement of antiapoptotic BCL2 and c-IAP1 genes. J Biol.Chem. 2-16-2007;282:4288-4300. View abstract.
  1239. Lee, C. W., Lin, C. C., Lin, W. N., Liang, K. C., Luo, S. F., Wu, C. B., Wang, S. W., and Yang, C. M. TNF-alpha induces MMP-9 expression via activation of Src/EGFR, PDGFR/PI3K/Akt cascade and promotion of NF-kappaB/p300 binding in human tracheal smooth muscle cells. Am.J Physiol Lung Cell Mol.Physiol 2007;292:L799-L812. View abstract.
  1240. Liddle, M., Hull, C., Liu, C., and Powell, D. Contact urticaria from curcumin. Dermatitis 2006;17:196-197. View abstract.
  1241. Patumraj, S., Wongeakin, N., Sridulyakul, P., Jariyapongskul, A., Futrakul, N., and Bunnag, S. Combined effects of curcumin and vitamin C to protect endothelial dysfunction in the iris tissue of STZ-induced diabetic rats. Clin Hemorheol.Microcirc. 2006;35:481-489. View abstract.
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  1244. Cui, L., Miao, J., and Cui, L. Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species. Antimicrob.Agents Chemother. 2007;51:488-494. View abstract.
  1245. McNally, S. J., Harrison, E. M., Ross, J. A., Garden, O. J., and Wigmore, S. J. Curcumin induces heme oxygenase 1 through generation of reactive oxygen species, p38 activation and phosphatase inhibition. Int.J Mol.Med. 2007;19:165-172. View abstract.
  1246. Furusu, A., Nakayama, K., Xu, Q., Konta, T., and Kitamura, M. MAP kinase-dependent, NF-kappaB-independent regulation of inhibitor of apoptosis protein genes by TNF-alpha. J Cell Physiol 2007;210:703-710. View abstract.
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  1248. Salimei, P. S., Marfe, G., Di Renzo, L., Di Stefano, C., Giganti, M. G., Filomeni, G., and Ciriolo, M. R. The interference of rosmarinic acid in the DNA fragmentation induced by osmotic shock. Front Biosci. 2007;12:1308-1317. View abstract.
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  1250. Anuchapreeda, S., Thanarattanakorn, P., Sittipreechacharn, S., Tima, S., Chanarat, P., and Limtrakul, P. Inhibitory effect of curcumin on MDR1 gene expression in patient leukemic cells. Arch.Pharm Res 2006;29:866-873. View abstract.
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  1255. Ono, K., Naiki, H., and Yamada, M. The development of preventives and therapeutics for Alzheimer's disease that inhibit the formation of beta-amyloid fibrils (fAbeta), as well as destabilize preformed fAbeta. Curr.Pharm Des 2006;12:4357-4375. View abstract.
  1256. Hanai, H., Iida, T., Takeuchi, K., Watanabe, F., Maruyama, Y., Andoh, A., Tsujikawa, T., Fujiyama, Y., Mitsuyama, K., Sata, M., Yamada, M., Iwaoka, Y., Kanke, K., Hiraishi, H., Hirayama, K., Arai, H., Yoshii, S., Uchijima, M., Nagata, T., and Koide, Y. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol.Hepatol. 2006;4:1502-1506. View abstract.
  1257. Mukherjee Nee, Chakraborty S., Ghosh, U., Bhattacharyya, N. P., Bhattacharya, R. K., Dey, S., and Roy, M. Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity. Mol.Cell Biochem. 2007;297(1-2):31-39. View abstract.
  1258. Huang, X. R., Qi, M. X., and Kang, K. R. [Apoptosis of lens epithelial cell induced by curcumin and its mechanism]. Zhonghua Yan.Ke.Za Zhi. 2006;42:649-653. View abstract.
  1259. Ebert, B., Seidel, A., and Lampen, A. Phytochemicals induce breast cancer resistance protein in Caco-2 cells and enhance the transport of benzo[a]pyrene-3-sulfate. Toxicol Sci. 2007;96:227-236. View abstract.
  1260. Pari, L. and Murugan, P. Tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney. Basic Clin Pharmacol Toxicol 2006;99:329-334. View abstract.
  1261. Funk, J. L., Frye, J. B., Oyarzo, J. N., Kuscuoglu, N., Wilson, J., McCaffrey, G., Stafford, G., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., Kiela, P. R., and Timmermann, B. N. Efficacy and mechanism of action of turmeric supplements in the treatment of experimental arthritis. Arthritis Rheum. 2006;54:3452-3464. View abstract.
  1262. Gupta, K. K., Bharne, S. S., Rathinasamy, K., Naik, N. R., and Panda, D. Dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding. FEBS J 2006;273:5320-5332. View abstract.
  1263. Marczylo, T. H., Verschoyle, R. D., Cooke, D. N., Morazzoni, P., Steward, W. P., and Gescher, A. J. Comparison of systemic availability of curcumin with that of curcumin formulated with phosphatidylcholine. Cancer Chemother.Pharmacol 2007;60:171-177. View abstract.
  1264. Pan, ChJ, Tang, J. J., Weng, Y. J., Wang, J., and Huang, N. Preparation, characterization and anticoagulation of curcumin-eluting controlled biodegradable coating stents. J Control Release 2006;116:42-49. View abstract.
  1265. Tayyem, R. F., Heath, D. D., Al Delaimy, W. K., and Rock, C. L. Curcumin content of turmeric and curry powders. Nutr.Cancer 2006;55:126-131. View abstract.
  1266. Chen, C., Johnston, T. D., Wu, G., and Ranjan, D. Curcumin has potent liver preservation properties in an isolated perfusion model. Transplantation 10-15-2006;82:931-937. View abstract.
  1267. Khopde, M., Priyadarsini, K. I., Venkatesan, P., and Rao, M. N. Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue. Biophys.Chem. 8-9-1999;80:85-91. View abstract.
  1268. Khan, A., Bryden, N. A., Polansky, M. M., and Anderson, R. A. Insulin potentiating factor and chromium content of selected foods and spices. Biol Trace Elem.Res 1990;24:183-188. View abstract.
  1269. Xu, Y., Ku, B., Tie, L., Yao, H., Jiang, W., Ma, X., and Li, X. Curcumin reverses the effects of chronic stress on behavior, the HPA axis, BDNF expression and phosphorylation of CREB. Brain Res 11-29-2006;1122:56-64. View abstract.
  1270. Cheng, Y., Ping, J., Liu, C., Tan, Y. Z., and Chen, G. F. Study on effects of extracts from Salvia Miltiorrhiza and Curcuma Longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells. Chin J Integr.Med. 2006;12:207-211. View abstract.
  1271. Sharma, S., Kulkarni, S. K., and Chopra, K. Curcumin, the active principle of turmeric (Curcuma longa), ameliorates diabetic nephropathy in rats. Clin Exp.Pharmacol Physiol 2006;33:940-945. View abstract.
  1272. Mattson, M. P. and Cheng, A. Neurohormetic phytochemicals: Low-dose toxins that induce adaptive neuronal stress responses. Trends Neurosci. 2006;29:632-639. View abstract.
  1273. Raju, T. N., Kumar, C. S., Kanth, V. R., Ramana, B. V., Reddy, P. U., Suryanarayana, P., and Reddy, G. B. Cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in Wistar rats. Indian J Exp.Biol. 2006;44:733-739.View abstract.
  1274. Zhang, L., Fiala, M., Cashman, J., Sayre, J., Espinosa, A., Mahanian, M., Zaghi, J., Badmaev, V., Graves, M. C., Bernard, G., and Rosenthal, M. Curcuminoids enhance amyloid-beta uptake by macrophages of Alzheimer's disease patients. J Alzheimers.Dis. 2006;10:1-7. View abstract.
  1275. Ganiger, S., Malleshappa, H. N., Krishnappa, H., Rajashekhar, G., Ramakrishna, Rao, V, and Sullivan, F. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats. Food Chem.Toxicol 2007;45:64-69. View abstract.
  1276. Ruiz-Torres, M. P., Perez-Rivero, G., Diez-Marques, M. L., Griera, M., Ortega, R., Rodriguez-Puyol, M., and Rodriguez-Puyol, D. Role of activator protein-1 on the effect of arginine-glycine-aspartic acid containing peptides on transforming growth factor-beta1 promoter activity. Int.J Biochem.Cell Biol. 2007;39:133-145. View abstract.
  1277. Tonnesen, H. H. Solubility and stability of curcumin in solutions containing alginate and other viscosity modifying macromolecules. Studies of curcumin and curcuminoids. XXX. Pharmazie 2006;61:696-700. View abstract.
  1278. Fan, C., Wo, X., Dou, X., Xu, L., Qian, Y., Luo, Y., and Yan, J. Regulation of LDL receptor expression by the effect of curcumin on sterol regulatory element pathway. Pharmacol Rep. 2006;58:577-581. View abstract.
  1279. Zheng, S. and Chen, A. Disruption of transforming growth factor-beta signaling by curcumin induces gene expression of peroxisome proliferator-activated receptor-gamma in rat hepatic stellate cells. Am.J Physiol Gastrointest.Liver Physiol 2007;292:G113-G123. View abstract.
  1280. Blasius, R., Reuter, S., Henry, E., Dicato, M., and Diederich, M. Curcumin regulates signal transducer and activator of transcription (STAT) expression in K562 cells. Biochem.Pharmacol 11-30-2006;72:1547-1554. View abstract.
  1281. Thompson, D. A. and Tan, B. B. Tetrahydracurcumin-related allergic contact dermatitis. Contact Dermatitis 2006;55:254-255.View abstract.
  1282. Niture, S. K., Velu, C. S., Smith, Q. R., Bhat, G. J., and Srivenugopal, K. S. Increased expression of the MGMT repair protein mediated by cysteine prodrugs and chemopreventative natural products in human lymphocytes and tumor cell lines. Carcinogenesis 2007;28:378-389. View abstract.
  1283. Weber, W. M., Hunsaker, L. A., Gonzales, A. M., Heynekamp, J. J., Orlando, R. A., Deck, L. M., and Vander Jagt, D. L. TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin. Biochem.Pharmacol 10-16-2006;72:928-940. View abstract.
  1284. Ganguly, K., Kundu, P., Banerjee, A., Reiter, R. J., and Swarnakar, S. Hydrogen peroxide-mediated downregulation of matrix metalloprotease-2 in indomethacin-induced acute gastric ulceration is blocked by melatonin and other antioxidants. Free Radic.Biol.Med. 9-15-2006;41:911-925. View abstract.
  1285. Jung, K. K., Lee, H. S., Cho, J. Y., Shin, W. C., Rhee, M. H., Kim, T. G., Kang, J. H., Kim, S. H., Hong, S., and Kang, S. Y. Inhibitory effect of curcumin on nitric oxide production from lipopolysaccharide-activated primary microglia. Life Sci. 10-19-2006;79:2022-2031. View abstract.
  1286. Krejsgaard, T., Vetter-Kauczok, C. S., Woetmann, A., Lovato, P., Labuda, T., Eriksen, K. W., Zhang, Q., Becker, J. C., and Odum, N. Jak3- and JNK-dependent vascular endothelial growth factor expression in cutaneous T-cell lymphoma. Leukemia 2006;20:1759-1766. View abstract.
  1287. Qin, N. Y., Yang, F. Q., Wang, Y. T., and Li, S. P. Quantitative determination of eight components in rhizome (Jianghuang) and tuberous root (Yujin) of Curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry. J Pharm Biomed.Anal. 1-17-2007;43:486-492. View abstract.
  1288. Chan, W. H. and Wu, H. J. Protective effects of curcumin on methylglyoxal-induced oxidative DNA damage and cell injury in human mononuclear cells. Acta Pharmacol Sin. 2006;27:1192-1198. View abstract.
  1289. Rahman, I., Biswas, S. K., and Kirkham, P. A. Regulation of inflammation and redox signaling by dietary polyphenols. Biochem.Pharmacol 11-30-2006;72:1439-1452. View abstract.
  1290. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on lipid peroxidation and lipids in streptozotocin-nicotinamide-induced diabetic rats. Basic Clin Pharmacol Toxicol 2006;99:122-127. View abstract.
  1291. Rajeswari, A. Curcumin protects mouse brain from oxidative stress caused by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Eur.Rev.Med.Pharmacol Sci. 2006;10:157-161. View abstract.
  1292. Ramassamy, C. Emerging role of polyphenolic compounds in the treatment of neurodegenerative diseases: a review of their intracellular targets. Eur.J Pharmacol 9-1-2006;545:51-64. View abstract.
  1293. Uno, J. K., Kolek, O. I., Hines, E. R., Xu, H., Timmermann, B. N., Kiela, P. R., and Ghishan, F. K. The role of tumor necrosis factor alpha in down-regulation of osteoblast Phex gene expression in experimental murine colitis. Gastroenterology 2006;131:497-509. View abstract.
  1294. Choi, H., Chun, Y. S., Kim, S. W., Kim, M. S., and Park, J. W. Curcumin inhibits hypoxia-inducible factor-1 by degrading aryl hydrocarbon receptor nuclear translocator: a mechanism of tumor growth inhibition. Mol.Pharmacol 2006;70:1664-1671. View abstract.
  1295. Chowdhury, P., Sacks, S. H., and Sheerin, N. S. Toll-like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products. Clin Exp.Immunol. 2006;145:346-356. View abstract.
  1296. Kaur, G., Tirkey, N., Bharrhan, S., Chanana, V., Rishi, P., and Chopra, K. Inhibition of oxidative stress and cytokine activity by curcumin in amelioration of endotoxin-induced experimental hepatoxicity in rodents. Clin Exp.Immunol. 2006;145:313-321. View abstract.
  1297. Ng, T. P., Chiam, P. C., Lee, T., Chua, H. C., Lim, L., and Kua, E. H. Curry consumption and cognitive function in the elderly. Am.J Epidemiol. 11-1-2006;164:898-906. View abstract.
  1298. Zhang, M., Deng, C. S., Zheng, J. J., and Xia, J. Curcumin regulated shift from Th1 to Th2 in trinitrobenzene sulphonic acid-induced chronic colitis. Acta Pharmacol Sin. 2006;27:1071-1077. View abstract.
  1299. Wolanin, K., Magalska, A., Mosieniak, G., Klinger, R., McKenna, S., Vejda, S., Sikora, E., and Piwocka, K. Curcumin affects components of the chromosomal passenger complex and induces mitotic catastrophe in apoptosis-resistant Bcr-Abl-expressing cells. Mol.Cancer Res 2006;4:457-469. View abstract.
  1300. Farhangkhoee, H., Khan, Z. A., Chen, S., and Chakrabarti, S. Differential effects of curcumin on vasoactive factors in the diabetic rat heart. Nutr.Metab (Lond) 2006;3:27. View abstract.
  1301. Zhou, G., Niu, J. Z., Wang, J. F., Chen, W. T., Liu, T. X., Li, Y. S., and Li, Z. H. [Experimental study on effect of curcumin on inhibiting injury of free radical in pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31:669-672. View abstract.
  1302. Wu, R., Cui, X., Dong, W., Zhou, M., Simms, H. H., and Wang, P. Suppression of hepatocyte CYP1A2 expression by Kupffer cells via AhR pathway: the central role of proinflammatory cytokines. Int.J Mol.Med. 2006;18:339-346. View abstract.
  1303. Cui, S. X., Qu, X. J., Xie, Y. Y., Zhou, L., Nakata, M., Makuuchi, M., and Tang, W. Curcumin inhibits telomerase activity in human cancer cell lines. Int.J Mol.Med. 2006;18:227-231. View abstract.
  1304. Vemula, P. K., Li, J., and John, G. Enzyme catalysis: tool to make and break amygdalin hydrogelators from renewable resources: a delivery model for hydrophobic drugs. J Am.Chem.Soc. 7-12-2006;128:8932-8938. View abstract.
  1305. Naganuma, M., Saruwatari, A., Okamura, S., and Tamura, H. Turmeric and curcumin modulate the conjugation of 1-naphthol in Caco-2 cells. Biol.Pharm Bull. 2006;29:1476-1479. View abstract.
  1306. Moon, D. O., Jin, C. Y., Lee, J. D., Choi, Y. H., Ahn, S. C., Lee, C. M., Jeong, S. C., Park, Y. M., and Kim, G. Y. Curcumin decreases binding of Shiga-like toxin-1B on human intestinal epithelial cell line HT29 stimulated with TNF-alpha and IL-1beta: suppression of p38, JNK and NF-kappaB p65 as potential targets. Biol.Pharm Bull. 2006;29:1470-1475. View abstract.
  1307. Farombi, E. O. and Ekor, M. Curcumin attenuates gentamicin-induced renal oxidative damage in rats. Food Chem.Toxicol 2006;44:1443-1448. View abstract.
  1308. Jackson, J. K., Higo, T., Hunter, W. L., and Burt, H. M. The antioxidants curcumin and quercetin inhibit inflammatory processes associated with arthritis. Inflamm.Res 2006;55:168-175. View abstract.
  1309. Eybl, V., Kotyzova, D., and Koutensky, J. Comparative study of natural antioxidants - curcumin, resveratrol and melatonin - in cadmium-induced oxidative damage in mice. Toxicology 8-15-2006;225(2-3):150-156. View abstract.
  1310. Murugan, P. and Pari, L. Antioxidant effect of tetrahydrocurcumin in streptozotocin-nicotinamide induced diabetic rats. Life Sci. 9-27-2006;79:1720-1728. View abstract.
  1311. Mori, Y., Tatematsu, K., Koide, A., Sugie, S., Tanaka, T., and Mori, H. Modification by curcumin of mutagenic activation of carcinogenic N-nitrosamines by extrahepatic cytochromes P-450 2B1 and 2E1 in rats. Cancer Sci. 2006;97:896-904. View abstract.
  1312. Jiang, H., Deng, C. S., Zhang, M., and Xia, J. Curcumin-attenuated trinitrobenzene sulphonic acid induces chronic colitis by inhibiting expression of cyclooxygenase-2. World J Gastroenterol. 6-28-2006;12:3848-3853. View abstract.
  1313. Ali, R. E. and Rattan, S. I. Curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes. Ann.N.Y Acad.Sci. 2006;1067:394-399. View abstract.
  1314. Bala, K., Tripathy, B. C., and Sharma, D. Neuroprotective and anti-ageing effects of curcumin in aged rat brain regions. Biogerontology. 2006;7:81-89. View abstract.
  1315. Marcu, M. G., Jung, Y. J., Lee, S., Chung, E. J., Lee, M. J., Trepel, J., and Neckers, L. Curcumin is an inhibitor of p300 histone acetylatransferase. Med.Chem. 2006;2:169-174. View abstract.
  1316. Tohda, C., Nakayama, N., Hatanaka, F., and Komatsu, K. Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract. Evid.Based.Complement Alternat.Med. 2006;3:255-260. View abstract.
  1317. Zhang, M., Deng, C., Zheng, J., Xia, J., and Sheng, D. Curcumin inhibits trinitrobenzene sulphonic acid-induced colitis in rats by activation of peroxisome proliferator-activated receptor gamma. Int.Immunopharmacol. 2006;6:1233-1242. View abstract.
  1318. Jain, S. K., Rains, J., and Jones, K. Effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels. Free Radic.Biol.Med. 7-1-2006;41:92-96. View abstract.
  1319. Zhou, G., Wang, J. F., Niu, J. Z., Lu, Y. S., Chen, W. T., Li, Z. H., and Lin, T. X. [Experimental study on protective effects of curcumin on exaggerated extracellular matrix accumulation of pulmonary fibrosis rats]. Zhongguo Zhong.Yao Za Zhi. 2006;31:570-573.View abstract.
  1320. Parodi, F. E., Mao, D., Ennis, T. L., Pagano, M. B., and Thompson, R. W. Oral administration of diferuloylmethane (curcumin) suppresses proinflammatory cytokines and destructive connective tissue remodeling in experimental abdominal aortic aneurysms. Ann.Vasc.Surg. 2006;20:360-368. View abstract.
  1321. Belkaid, A., Copland, I. B., Massillon, D., and Annabi, B. Silencing of the human microsomal glucose-6-phosphate translocase induces glioma cell death: potential new anticancer target for curcumin. FEBS Lett. 6-26-2006;580:3746-3752. View abstract.
  1322. Ndamukong, K. J., Ntonifor, N. N., Mbuh, J., Atemnkeng, A. F., and Akam, M. T. Molluscicidal activity of some Cameroonian plants on Bulinus species. East Afr.Med.J 2006;83:102-109. View abstract.
  1323. Al Omar, F. A., Nagi, M. N., Abdulgadir, M. M., Al Joni, K. S., and Al Majed, A. A. Immediate and delayed treatments with curcumin prevents forebrain ischemia-induced neuronal damage and oxidative insult in the rat hippocampus. Neurochem.Res 2006;31:611-618. View abstract.
  1324. Panchatcharam, M., Miriyala, S., Gayathri, V. S., and Suguna, L. Curcumin improves wound healing by modulating collagen and decreasing reactive oxygen species. Mol.Cell Biochem. 2006;290(1-2):87-96. View abstract.
  1325. Nieman, D. C. and Bishop, N. C. Nutritional strategies to counter stress to the immune system in athletes, with special reference to football. J Sports Sci. 2006;24:763-772. View abstract.
  1326. Okunieff, P., Xu, J., Hu, D., Liu, W., Zhang, L., Morrow, G., Pentland, A., Ryan, J. L., and Ding, I. Curcumin protects against radiation-induced acute and chronic cutaneous toxicity in mice and decreases mRNA expression of inflammatory and fibrogenic cytokines. Int.J Radiat.Oncol.Biol.Phys. 7-1-2006;65:890-898. View abstract.
  1327. He, Y. J., Shu, J. C., Lu, X., Fang, L., and Sheng, Y. [Prophylactic effect of curcumin on hepatic fibrosis and its relationship with activated hepatic stellate cells]. Zhonghua Gan Zang.Bing.Za Zhi. 2006;14:337-340. View abstract.
  1328. Wu, L. X., Xu, J. H., Huang, X. W., Zhang, K. Z., Wen, C. X., and Chen, Y. Z. Down-regulation of p210(bcr/abl) by curcumin involves disrupting molecular chaperone functions of Hsp90. Acta Pharmacol Sin. 2006;27:694-699. View abstract.
  1329. Liu, Y. and Hong, X. Q. [Effect of three different curcumin pigmens on the prdiferation of vascular smooth muscle cells by ox-LDL and the expression of LDL-R]. Zhongguo Zhong.Yao Za Zhi. 2006;31:500-503. View abstract.
  1330. Durham, W. J., Arbogast, S., Gerken, E., Li, Y. P., and Reid, M. B. Progressive nuclear factor-kappaB activation resistant to inhibition by contraction and curcumin in mdx mice. Muscle Nerve 2006;34:298-303. View abstract.
  1331. Siddiqui, A. M., Cui, X., Wu, R., Dong, W., Zhou, M., Hu, M., Simms, H. H., and Wang, P. The anti-inflammatory effect of curcumin in an experimental model of sepsis is mediated by up-regulation of peroxisome proliferator-activated receptor-gamma. Crit Care Med. 2006;34:1874-1882. View abstract.
  1332. Peschel, D., Koerting, R., and Nass, N. Curcumin induces changes in expression of genes involved in cholesterol homeostasis. J Nutr.Biochem. 2007;18:113-119. View abstract.
  1333. Lu, P., Tong, Q., Jiang, F., Zheng, L., Chen, F., Zeng, F., Dong, J., and Du, Y. Preparation of curcumin prodrugs and their in vitro anti-tumor activities. J Huazhong.Univ Sci.Technolog.Med.Sci. 2005;25:668-70, 678. View abstract.
  1334. Vanisree, A. J. and Sudha, N. Curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver. Mol.Cell Biochem. 2006;288(1-2):115-123. View abstract.
  1335. Youn, H. S., Saitoh, S. I., Miyake, K., and Hwang, D. H. Inhibition of homodimerization of Toll-like receptor 4 by curcumin. Biochem.Pharmacol 6-28-2006;72:62-69. View abstract.
  1336. Perez-Arriaga, L., Mendoza-Magana, M. L., Cortes-Zarate, R., Corona-Rivera, A., Bobadilla-Morales, L., Troyo-Sanroman, R., and Ramirez-Herrera, M. A. Cytotoxic effect of curcumin on Giardia lamblia trophozoites. Acta Trop. 2006;98:152-161. View abstract.
  1337. Scapagnini, G., Colombrita, C., Amadio, M., D'Agata, V., Arcelli, E., Sapienza, M., Quattrone, A., and Calabrese, V. Curcumin activates defensive genes and protects neurons against oxidative stress. Antioxid.Redox.Signal. 2006;8(3-4):395-403. View abstract.
  1338. Yuan, G., Wahlqvist, M. L., He, G., Yang, M., and Li, D. Natural products and anti-inflammatory activity. Asia Pac.J Clin Nutr. 2006;15:143-152. View abstract.
  1339. Xia, X., Pan, Y., Zhang, W. Y., Cheng, G., and Kong, L. D. Ethanolic extracts from Curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model. Biol.Pharm Bull. 2006;29:938-944. View abstract.
  1340. Sikora, E., Bielak-Zmijewska, A., Magalska, A., Piwocka, K., Mosieniak, G., Kalinowska, M., Widlak, P., Cymerman, I. A., and Bujnicki, J. M. Curcumin induces caspase-3-dependent apoptotic pathway but inhibits DNA fragmentation factor 40/caspase-activated DNase endonuclease in human Jurkat cells. Mol.Cancer Ther. 2006;5:927-934. View abstract.
  1341. Liu, H., Danthi, S. J., and Enyeart, J. J. Curcumin potently blocks Kv1.4 potassium channels. Biochem.Biophys.Res Commun. 6-16-2006;344:1161-1165. View abstract.
  1342. Kang, S. K., Cha, S. H., and Jeon, H. G. Curcumin-induced histone hypoacetylation enhances caspase-3-dependent glioma cell death and neurogenesis of neural progenitor cells. Stem Cells Dev. 2006;15:165-174. View abstract.
  1343. Norez, C., Antigny, F., Becq, F., and Vandebrouck, C. Maintaining low Ca2+ level in the endoplasmic reticulum restores abnormal endogenous F508del-CFTR trafficking in airway epithelial cells. Traffic. 2006;7:562-573. View abstract.
  1344. Premanand, C., Rema, M., Sameer, M. Z., Sujatha, M., and Balasubramanyam, M. Effect of curcumin on proliferation of human retinal endothelial cells under in vitro conditions. Invest Ophthalmol.Vis.Sci. 2006;47:2179-2184. View abstract.
  1345. Cleary, K. and McFeeters, R. F. Effects of oxygen and turmeric on the formation of oxidative aldehydes in fresh-pack dill pickles. J Agric.Food Chem. 5-3-2006;54:3421-3427. View abstract.
  1346. Chattopadhyay, I., Bandyopadhyay, U., Biswas, K., Maity, P., and Banerjee, R. K. Indomethacin inactivates gastric peroxidase to induce reactive-oxygen-mediated gastric mucosal injury and curcumin protects it by preventing peroxidase inactivation and scavenging reactive oxygen. Free Radic.Biol.Med. 4-15-2006;40:1397-1408. View abstract.
  1347. Chan, W. H., Wu, H. Y., and Chang, W. H. Dosage effects of curcumin on cell death types in a human osteoblast cell line. Food Chem.Toxicol 2006;44:1362-1371. View abstract.
  1348. Nhujak, T., Saisuwan, W., Srisa-art, M., and Petsom, A. Microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples. J Sep.Sci. 2006;29:666-676. View abstract.
  1349. Taniura, H., Sng, J. C., and Yoneda, Y. Histone modifications in status epilepticus induced by kainate. Histol.Histopathol. 2006;21:785-791. View abstract.
  1350. Sharma, S., Kulkarni, S. K., Agrewala, J. N., and Chopra, K. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur.J Pharmacol 5-1-2006;536:256-261. View abstract.
  1351. Wang, Y. D., Hu, Y., and Sun, C. Y. [Inhibitory effect of curcumin on angiogenesis induced by brain derived neurotrophic factor from multiple myeloma cells]. Zhongguo Shi Yan.Xue.Ye.Xue.Za Zhi. 2006;14:70-74. View abstract.
  1352. Funk, J. L., Oyarzo, J. N., Frye, J. B., Chen, G., Lantz, R. C., Jolad, S. D., Solyom, A. M., and Timmermann, B. N. Turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis. J Nat.Prod. 2006;69:351-355. View abstract.
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  1357. Lao, C. D., Ruffin, M. T., Normolle, D., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J., Rock, C. L., and Brenner, D. E. Dose escalation of a curcuminoid formulation. BMC.Complement Altern.Med. 2006;6:10. View abstract.
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  1368. Atamna, H. and Boyle, K. Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease. Proc.Natl.Acad.Sci.U.S A 2-28-2006;103:3381-3386. View abstract.
  1369. Jiang, H., Timmermann, B. N., and Gang, D. R. Use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (Curcuma longa L.) rhizome. J Chromatogr.A 4-7-2006;1111:21-31. View abstract.
  1370. Schallreuter, K. U. and Rokos, H. Turmeric (curcumin): a widely used curry ingredient, can contribute to oxidative stress in Asian patients with acute vitiligo. Indian J Dermatol.Venereol.Leprol. 2006;72:57-59. View abstract.
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  1372. Sreepriya, M. and Bali, G. Effects of administration of Embelin and Curcumin on lipid peroxidation, hepatic glutathione antioxidant defense and hematopoietic system during N-nitrosodiethylamine/Phenobarbital-induced hepatocarcinogenesis in Wistar rats. Mol.Cell Biochem. 2006;284(1-2):49-55. View abstract.
  1373. Notoya, M., Nishimura, H., Woo, J. T., Nagai, K., Ishihara, Y., and Hagiwara, H. Curcumin inhibits the proliferation and mineralization of cultured osteoblasts. Eur.J Pharmacol 3-18-2006;534(1-3):55-62. View abstract.
  1374. Lu, M., Leng, Q., Egan, M. E., Caplan, M. J., Boulpaep, E. L., Giebisch, G. H., and Hebert, S. C. CFTR is required for PKA-regulated ATP sensitivity of Kir1.1 potassium channels in mouse kidney. J Clin Invest 2006;116:797-807. View abstract.
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  1376. Zhou, H., Wong, Y. F., Cai, X., Liu, Z. Q., Jiang, Z. H., Bian, Z. X., Xu, H. X., and Liu, L. Suppressive effects of JCICM-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents. Biol.Pharm Bull. 2006;29:253-260. View abstract.
  1377. Kuwabara, N., Tamada, S., Iwai, T., Teramoto, K., Kaneda, N., Yukimura, T., Nakatani, T., and Miura, K. Attenuation of renal fibrosis by curcumin in rat obstructive nephropathy. Urology 2006;67:440-446. View abstract.
  1378. Patel, H. J., Su, S. H., Patterson, C., and Nguyen, K. T. A combined strategy to reduce restenosis for vascular tissue engineering applications. Biotechnol.Prog. 2006;22:38-44. View abstract.
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  1380. Chen, W. H., Chen, Y., and Cui, G. H. Effects of TNF-alpha and curcumin on the expression of VEGF in Raji and U937 cells and on angiogenesis in ECV304 cells. Chin Med.J (Engl) 12-20-2005;118:2052-2057. View abstract.
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  1382. El Ashmawy, I. M., Ashry, K. M., El Nahas, A. F., and Salama, O. M. Protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice. Basic Clin Pharmacol Toxicol 2006;98:32-37. View abstract.
  1383. Lipecka, J., Norez, C., Bensalem, N., Baudouin-Legros, M., Planelles, G., Becq, F., Edelman, A., and Davezac, N. Rescue of DeltaF508-CFTR (cystic fibrosis transmembrane conductance regulator) by curcumin: involvement of the keratin 18 network. J Pharmacol Exp.Ther. 2006;317:500-505. View abstract.
  1384. Gulcubuk, A., Altunatmaz, K., Sonmez, K., Haktanir-Yatkin, D., Uzun, H., Gurel, A., and Aydin, S. Effects of curcumin on tumour necrosis factor-alpha and interleukin-6 in the late phase of experimental acute pancreatitis. J Vet.Med.A Physiol Pathol.Clin Med. 2006;53:49-54. View abstract.
  1385. Wootton, L. L. and Michelangeli, F. The effects of the phenylalanine 256 to valine mutation on the sensitivity of sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA) Ca2+ pump isoforms 1, 2, and 3 to thapsigargin and other inhibitors. J Biol.Chem. 3-17-2006;281:6970-6976. View abstract.
  1386. Hu, Y. H., Qi, M. X., Huang, X. R., Ma, L., Yan, J., and Wu, Z. Z. [Signal transduction mechanism of curcumin in inhibiting the proliferation of bovine lens epithelial cell induced by recombinant human epidermal growth factor]. Zhong.Xi.Yi.Jie.He.Xue.Bao. 2006;4:39-42. View abstract.
  1387. Fan, C., Wo, X., Qian, Y., Yin, J., and Gao, L. Effect of curcumin on the expression of LDL receptor in mouse macrophages. J Ethnopharmacol. 4-21-2006;105(1-2):251-254. View abstract.
  1388. Frank, B. and Gupta, S. A review of antioxidants and Alzheimer's disease. Ann.Clin Psychiatry 2005;17:269-286. View abstract.
  1389. Olszanecki, R., Jawien, J., Gajda, M., Mateuszuk, L., Gebska, A., Korabiowska, M., Chlopicki, S., and Korbut, R. Effect of curcumin on atherosclerosis in apoE/LDLR-double knockout mice. J Physiol Pharmacol 2005;56:627-635. View abstract.
  1390. Bengmark, S. Curcumin, an atoxic antioxidant and natural NFkappaB, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases. JPEN J Parenter.Enteral Nutr. 2006;30:45-51. View abstract.
  1391. Kulkarni, A. P., Ghebremariam, Y. T., and Kotwal, G. J. Curcumin inhibits the classical and the alternate pathways of complement activation. Ann.N.Y Acad.Sci. 2005;1056:100-112. View abstract.
  1392. Du, Z. Y., Liu, R. R., Shao, W. Y., Mao, X. P., Ma, L., Gu, L. Q., Huang, Z. S., and Chan, A. S. Alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs. Eur.J Med.Chem. 2006;41:213-218. View abstract.
  1393. Bernt, C., Vennegeerts, T., Beuers, U., and Rust, C. The human transcription factor AP-1 is a mediator of bile acid-induced liver cell apoptosis. Biochem.Biophys.Res Commun. 2-17-2006;340:800-806. View abstract.
  1394. Cho, M. L., Jung, Y. O., Moon, Y. M., Min, S. Y., Yoon, C. H., Lee, S. H., Park, S. H., Cho, C. S., Jue, D. M., and Kim, H. Y. Interleukin-18 induces the production of vascular endothelial growth factor (VEGF) in rheumatoid arthritis synovial fibroblasts via AP-1-dependent pathways. Immunol.Lett. 3-15-2006;103:159-166. View abstract.
  1395. Gupta, S. and Ravishankar, S. A comparison of the antimicrobial activity of garlic, ginger, carrot, and turmeric pastes against Escherichia coli O157:H7 in laboratory buffer and ground beef. Foodborne.Pathog.Dis. 2005;2:330-340. View abstract.
  1396. Wu, A., Ying, Z., and Gomez-Pinilla, F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp.Neurol. 2006;197:309-317. View abstract.
  1397. Shun, C. T., Lin, S. K., Hong, C. Y., Kok, S. H., Juan, Y. H., Wang, C. C., Hsu, M. C., and Liu, C. M. C-C chemokine ligand 2 gene expression in nasal polyp fibroblasts: possible implication in the pathogenesis of nasal polyposis. Ann.Otol.Rhinol.Laryngol. 2005;114:879-885. View abstract.
  1398. Kawanishi, S., Oikawa, S., and Murata, M. Evaluation for safety of antioxidant chemopreventive agents. Antioxid.Redox.Signal. 2005;7(11-12):1728-1739. View abstract.
  1399. Eybl, V., Kotyzova, D., Leseticky, L., Bludovska, M., and Koutensky, J. The influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice. J Appl.Toxicol 2006;26:207-212.View abstract.
  1400. Yang, L., Zhang, L. Y., Chen, W. W., Kong, F., Zhang, P. J., Hu, X. Y., Zhang, J. Y., and Cui, F. A. [Inhibition of the expression of prostate specific antigen by curcumin]. Yao Xue.Xue.Bao. 2005;40:800-803. View abstract.
  1401. Weber-Mzell, D., Zaupa, P., Petnehazy, T., Kobayashi, H., Schimpl, G., Feierl, G., Kotanko, P., and Hollwarth, M. The role of nuclear factor-kappa B in bacterial translocation in cholestatic rats. Pediatr.Surg.Int. 2006;22:43-49. View abstract.
  1402. Kim, D. C., Kim, S. H., Choi, B. H., Baek, N. I., Kim, D., Kim, M. J., and Kim, K. T. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol.Pharm Bull. 2005;28:2220-2224. View abstract.
  1403. Cai, Y. Z., Mei, Sun, Jie, Xing, Luo, Q., and Corke, H. Structure-radical scavenging activity relationships of phenolic compounds from traditional Chinese medicinal plants. Life Sci. 5-15-2006;78:2872-2888. View abstract.
  1404. Shakibaei, M., Schulze-Tanzil, G., John, T., and Mobasheri, A. Curcumin protects human chondrocytes from IL-l1beta-induced inhibition of collagen type II and beta1-integrin expression and activation of caspase-3: an immunomorphological study. Ann.Anat. 2005;187(5-6):487-497. View abstract.
  1405. Liu, A., Lou, H., Zhao, L., and Fan, P. Validated LC/MS/MS assay for curcumin and tetrahydrocurcumin in rat plasma and application to pharmacokinetic study of phospholipid complex of curcumin. J Pharm Biomed.Anal. 2-24-2006;40:720-727. View abstract.
  1406. Yang, C., Wang, Z. G., Chen, L. Y., Zhou, J., Zhu, P. F., and Jiang, J. X. Silencing effect of recombinant plasmids PPARgamma-pSUPER-EGFP on the expression of peroxisome proliferator-activated receptor gamma. Chin J Traumatol. 2005;8:352-357. View abstract.
  1407. Kumar, P. A., Haseeb, A., Suryanarayana, P., Ehtesham, N. Z., and Reddy, G. B. Elevated expression of alphaA- and alphaB-crystallins in streptozotocin-induced diabetic rat. Arch.Biochem.Biophys. 12-15-2005;444:77-83. View abstract.
  1408. Zheng, S. and Chen, A. Curcumin suppresses the expression of extracellular matrix genes in activated hepatic stellate cells by inhibiting gene expression of connective tissue growth factor. Am.J Physiol Gastrointest.Liver Physiol 2006;290:G883-G893. View abstract.
  1409. Thomas, R. K., Sos, M. L., Zander, T., Mani, O., Popov, A., Berenbrinker, D., Smola-Hess, S., Schultze, J. L., and Wolf, J. Inhibition of nuclear translocation of nuclear factor-kappaB despite lack of functional IkappaBalpha protein overcomes multiple defects in apoptosis signaling in human B-cell malignancies. Clin Cancer Res 11-15-2005;11:8186-8194. View abstract.
  1410. Zbarsky, V., Datla, K. P., Parkar, S., Rai, D. K., Aruoma, O. I., and Dexter, D. T. Neuroprotective properties of the natural phenolic antioxidants curcumin and naringenin but not quercetin and fisetin in a 6-OHDA model of Parkinson's disease. Free Radic.Res 2005;39:1119-1125. View abstract.
  1411. Masamune, A., Suzuki, N., Kikuta, K., Satoh, M., Satoh, K., and Shimosegawa, T. Curcumin blocks activation of pancreatic stellate cells. J Cell Biochem. 4-1-2006;97:1080-1093. View abstract.
  1412. Lee, C. W., Lin, W. N., Lin, C. C., Luo, S. F., Wang, J. S., Pouyssegur, J., and Yang, C. M. Transcriptional regulation of VCAM-1 expression by tumor necrosis factor-alpha in human tracheal smooth muscle cells: involvement of MAPKs, NF-kappaB, p300, and histone acetylation. J Cell Physiol 2006;207:174-186. View abstract.
  1413. Grubb, B. R., Gabriel, S. E., Mengos, A., Gentzsch, M., Randell, S. H., Van Heeckeren, A. M., Knowles, M. R., Drumm, M. L., Riordan, J. R., and Boucher, R. C. SERCA pump inhibitors do not correct biosynthetic arrest of deltaF508 CFTR in cystic fibrosis. Am.J Respir.Cell Mol.Biol. 2006;34:355-363. View abstract.
  1414. Park, B. S., Kim, J. G., Kim, M. R., Lee, S. E., Takeoka, G. R., Oh, K. B., and Kim, J. H. Curcuma longa L. constituents inhibit sortase A and Staphylococcus aureus cell adhesion to fibronectin. J Agric.Food Chem. 11-16-2005;53:9005-9009. View abstract.
  1415. Hu, M., Du, Q., Vancurova, I., Lin, X., Miller, E. J., Simms, H. H., and Wang, P. Proapoptotic effect of curcumin on human neutrophils: activation of the p38 mitogen-activated protein kinase pathway. Crit Care Med. 2005;33:2571-2578. View abstract.
  1416. Misonou, Y., Asahi, M., Yokoe, S., Miyoshi, E., and Taniguchi, N. Acrolein produces nitric oxide through the elevation of intracellular calcium levels to induce apoptosis in human umbilical vein endothelial cells: implications for smoke angiopathy. Nitric.Oxide. 2006;14:180-187. View abstract.
  1417. Robben, J. H., Sze, M., Knoers, N. V., and Deen, P. M. Rescue of vasopressin V2 receptor mutants by chemical chaperones: specificity and mechanism. Mol.Biol.Cell 2006;17:379-386. View abstract.
  1418. Sumanont, Y., Murakami, Y., Tohda, M., Vajragupta, O., Watanabe, H., and Matsumoto, K. Prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin. Life Sci. 3-13-2006;78:1884-1891. View abstract.
  1419. Kempaiah, R. K. and Srinivasan, K. Beneficial influence of dietary curcumin, capsaicin and garlic on erythrocyte integrity in high-fat fed rats. J Nutr.Biochem. 2006;17:471-478. View abstract.
  1420. D'Incalci, M., Steward, W. P., and Gescher, A. J. Use of cancer chemopreventive phytochemicals as antineoplastic agents. Lancet Oncol. 2005;6:899-904. View abstract.
  1421. Khajavi, M., Inoue, K., Wiszniewski, W., Ohyama, T., Snipes, G. J., and Lupski, J. R. Curcumin treatment abrogates endoplasmic reticulum retention and aggregation-induced apoptosis associated with neuropathy-causing myelin protein zero-truncating mutants. Am.J Hum.Genet. 2005;77:841-850. View abstract.
  1422. Kim, H., Park, B. S., Lee, K. G., Choi, C. Y., Jang, S. S., Kim, Y. H., and Lee, S. E. Effects of naturally occurring compounds on fibril formation and oxidative stress of beta-amyloid. J Agric.Food Chem. 11-2-2005;53:8537-8541. View abstract.
  1423. Wung, B. S., Hsu, M. C., Wu, C. C., and Hsieh, C. W. Piceatannol upregulates endothelial heme oxygenase-1 expression via novel protein kinase C and tyrosine kinase pathways. Pharmacol Res 2006;53:113-122. View abstract.
  1424. Holt, P. R., Katz, S., and Kirshoff, R. Curcumin therapy in inflammatory bowel disease: a pilot study. Dig.Dis.Sci. 2005;50:2191-2193. View abstract.
  1425. Yang, X., Thomas, D. P., Zhang, X., Culver, B. W., Alexander, B. M., Murdoch, W. J., Rao, M. N., Tulis, D. A., Ren, J., and Sreejayan, N. Curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation. Arterioscler.Thromb.Vasc.Biol. 2006;26:85-90. View abstract.
  1426. Yadav, V. S., Mishra, K. P., Singh, D. P., Mehrotra, S., and Singh, V. K. Immunomodulatory effects of curcumin. Immunopharmacol.Immunotoxicol. 2005;27:485-497. View abstract.
  1427. Tirkey, N., Kaur, G., Vij, G., and Chopra, K. Curcumin, a diferuloylmethane, attenuates cyclosporine-induced renal dysfunction and oxidative stress in rat kidneys. BMC.Pharmacol 2005;5:15. View abstract.
  1428. Gaedeke, J., Noble, N. A., and Border, W. A. Curcumin blocks fibrosis in anti-Thy 1 glomerulonephritis through up-regulation of heme oxygenase 1. Kidney Int. 2005;68:2042-2049. View abstract.
  1429. Majithiya, J. B. and Balaraman, R. Time-dependent changes in antioxidant enzymes and vascular reactivity of aorta in streptozotocin-induced diabetic rats treated with curcumin. J Cardiovasc.Pharmacol 2005;46:697-705. View abstract.
  1430. Ignjacev-Lazich, I., Kintsurashvili, E., Johns, C., Vitseva, O., Duka, A., Shenouda, S., Gavras, I., and Gavras, H. Angiotensin-converting enzyme regulates bradykinin receptor gene expression. Am.J Physiol Heart Circ.Physiol 2005;289:H1814-H1820. View abstract.
  1431. Cao, W. G., Morin, M., Sengers, V., Metz, C., Roger, T., Maheux, R., and Akoum, A. Tumour necrosis factor-alpha up-regulates macrophage migration inhibitory factor expression in endometrial stromal cells via the nuclear transcription factor NF-kappaB. Hum.Reprod. 2006;21:421-428. View abstract.
  1432. Polytarchou, C., Hatziapostolou, M., and Papadimitriou, E. Hydrogen peroxide stimulates proliferation and migration of human prostate cancer cells through activation of activator protein-1 and up-regulation of the heparin affin regulatory peptide gene. J Biol.Chem. 12-9-2005;280:40428-40435. View abstract.
  1433. Murugan, P. and Pari, L. Effect of tetrahydrocurcumin on erythromycin estolate-induced lipid peroxidation in rats. J Basic Clin Physiol Pharmacol 2005;16:1-15. View abstract.
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  1435. Xu, Y., Ku, B. S., Yao, H. Y., Lin, Y. H., Ma, X., Zhang, Y. H., and Li, X. J. Antidepressant effects of curcumin in the forced swim test and olfactory bulbectomy models of depression in rats. Pharmacol Biochem.Behav. 2005;82:200-206. View abstract.
  1436. Kim, K. J., Yu, H. H., Cha, J. D., Seo, S. J., Choi, N. Y., and You, Y. O. Antibacterial activity of Curcuma longa L. against methicillin-resistant Staphylococcus aureus. Phytother.Res 2005;19:599-604. View abstract.
  1437. Liu, X. G., Dai, L., Yang, C., Zhao, Z. H., Zhang, X. R., Zhang, Z. G., and Guo, M. Y. Study on the signalling pathway of inhibitory effect of adreno-medullin on the growth of cultured glomerular mesangial cells. Chin Med.J (Engl) 8-20-2005;118:1374-1379.View abstract.
  1438. Ono, K., Hirohata, M., and Yamada, M. Ferulic acid destabilizes preformed beta-amyloid fibrils in vitro. Biochem.Biophys.Res Commun. 10-21-2005;336:444-449. View abstract.
  1439. Nan, B., Yang, H., Yan, S., Lin, P. H., Lumsden, A. B., Yao, Q., and Chen, C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery 2005;138:212-222. View abstract.
  1440. Yoysungnoen, P., Wirachwong, P., Bhattarakosol, P., Niimi, H., and Patumraj, S. Antiangiogenic activity of curcumin in hepatocellular carcinoma cells implanted nude mice. Clin Hemorheol.Microcirc. 2005;33:127-135. View abstract.
  1441. Narang, H. and Krishna, M. Inhibition of radiation induced nitration by curcumin and nicotinamide in mouse macrophages. Mol.Cell Biochem. 2005;276(1-2):7-13. View abstract.
  1442. Shen, F., Fan, X., Liu, B., Jia, X., Du, H., You, B., Ye, M., Huang, C., and Shi, X. Overexpression of cyclin D1-CDK4 in silica-induced transformed cells is due to activation of ERKs, JNKs/AP-1 pathway. Toxicol Lett. 1-25-2006;160:185-195. View abstract.
  1443. Farid, M., Reid, M. B., Li, Y. P., Gerken, E., and Durham, W. J. Effects of dietary curcumin or N-acetylcysteine on NF-kappaB activity and contractile performance in ambulatory and unloaded murine soleus. Nutr.Metab (Lond) 8-26-2005;2:20. View abstract.
  1444. Romero, M. R., Efferth, T., Serrano, M. A., Castano, B., Macias, R. I., Briz, O., and Marin, J. J. Effect of artemisinin/artesunate as inhibitors of hepatitis B virus production in an "in vitro" replicative system. Antiviral Res 2005;68:75-83. View abstract.
  1445. Rukkumani, R., Aruna, K., Varma, P. S., Rajasekaran, K. N., and Menon, V. P. Comparative effects of curcumin and its analog on alcohol- and polyunsaturated fatty acid-induced alterations in circulatory lipid profiles. J Med.Food 2005;8:256-260. View abstract.
  1446. Mahesh, T., Balasubashini, M. S., and Menon, V. P. Effect of photo-irradiated curcumin treatment against oxidative stress in streptozotocin-induced diabetic rats. J Med.Food 2005;8:251-255. View abstract.
  1447. Kalpana, C., Rajasekharan, K. N., and Menon, V. P. Modulatory effects of curcumin and curcumin analog on circulatory lipid profiles during nicotine-induced toxicity in Wistar rats. J Med.Food 2005;8:246-250. View abstract.
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  1449. Huang, M. T., Deschner, E. E., Newmark, H. L., Wang, Z. Y., Ferraro, T. A., and Conney, A. H. Effect of dietary curcumin and ascorbyl palmitate on azoxymethanol- induced colonic epithelial cell proliferation and focal areas of dysplasia. Cancer Lett. 6-15-1992;64:117-121. View abstract.
  1450. Lee, H. S. Antiplatelet property of Curcuma longa L. rhizome-derived ar-turmerone. Bioresour.Technol. 2006;97:1372-1376. View abstract.
  1451. Mutalik, S., Chetana, M., Sulochana, B., Devi, P. U., and Udupa, N. Effect of Dianex, a herbal formulation on experimentally induced diabetes mellitus. Phytother.Res 2005;19:409-415. View abstract.
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  1453. Kumar, P. A., Suryanarayana, P., Reddy, P. Y., and Reddy, G. B. Modulation of alpha-crystallin chaperone activity in diabetic rat lens by curcumin. Mol.Vis. 2005;11:561-568. View abstract.
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  1456. Suzuki, M., Nakamura, T., Iyoki, S., Fujiwara, A., Watanabe, Y., Mohri, K., Isobe, K., Ono, K., and Yano, S. Elucidation of anti-allergic activities of curcumin-related compounds with a special reference to their anti-oxidative activities. Biol.Pharm Bull. 2005;28:1438-1443. View abstract.
  1457. Matteucci, A., Frank, C., Domenici, M. R., Balduzzi, M., Paradisi, S., Carnovale-Scalzo, G., Scorcia, G., and Malchiodi-Albedi, F. Curcumin treatment protects rat retinal neurons against excitotoxicity: effect on N-methyl-D: -aspartate-induced intracellular Ca increase. Exp.Brain Res 2005;167:641-648. View abstract.
  1458. Wang, Q., Sun, A. Y., Simonyi, A., Jensen, M. D., Shelat, P. B., Rottinghaus, G. E., MacDonald, R. S., Miller, D. K., Lubahn, D. E., Weisman, G. A., and Sun, G. Y. Neuroprotective mechanisms of curcumin against cerebral ischemia-induced neuronal apoptosis and behavioral deficits. J Neurosci.Res 10-1-2005;82:138-148. View abstract.
  1459. Heath, D. D., Pruitt, M. A., Brenner, D. E., Begum, A. N., Frautschy, S. A., and Rock, C. L. Tetrahydrocurcumin in plasma and urine: quantitation by high performance liquid chromatography. J Chromatogr.B Analyt.Technol.Biomed.Life Sci. 9-25-2005;824(1-2):206-212. View abstract.
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  1465. Chearwae, W., Wu, C. P., Chu, H. Y., Lee, T. R., Ambudkar, S. V., and Limtrakul, P. Curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (ABCC1). Cancer Chemother.Pharmacol 2006;57:376-388. View abstract.
  1466. Ali, B. H., Al Wabel, N., Mahmoud, O., Mousa, H. M., and Hashad, M. Curcumin has a palliative action on gentamicin-induced nephrotoxicity in rats. Fundam.Clin Pharmacol 2005;19:473-477. View abstract.
  1467. Lantz, R. C., Chen, G. J., Solyom, A. M., Jolad, S. D., and Timmermann, B. N. The effect of turmeric extracts on inflammatory mediator production. Phytomedicine. 2005;12(6-7):445-452. View abstract.
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  1469. Cho, J. W., Park, K., Kweon, G. R., Jang, B. C., Baek, W. K., Suh, M. H., Kim, C. W., Lee, K. S., and Suh, S. I. Curcumin inhibits the expression of COX-2 in UVB-irradiated human keratinocytes (HaCaT) by inhibiting activation of AP-1: p38 MAP kinase and JNK as potential upstream targets. Exp.Mol.Med. 6-30-2005;37:186-192. View abstract.
  1470. Depeille, P., Cuq, P., Passagne, I., Evrard, A., and Vian, L. Combined effects of GSTP1 and MRP1 in melanoma drug resistance. Br.J Cancer 7-25-2005;93:216-223. View abstract.
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  1474. Bruzell, E. M., Morisbak, E., and Tonnesen, H. H. Studies on curcumin and curcuminoids. XXIX. Photoinduced cytotoxicity of curcumin in selected aqueous preparations. Photochem.Photobiol.Sci. 2005;4:523-530. View abstract.
  1475. Wuyts, W. A., Vanaudenaerde, B. M., Dupont, L. J., Van Raemdonck, D. E., Demedts, M. G., and Verleden, G. M. Interleukin-17--induced interleukin-8 release in human airway smooth muscle cells: role for mitogen-activated kinases and nuclear factor-kappaB. J Heart Lung Transplant. 2005;24:875-881. View abstract.
  1476. Gulcubuk, A., Sonmez, K., Gurel, A., Altunatmaz, K., Gurler, N., Aydin, S., Oksuz, L., Uzun, H., and Guzel, O. Pathologic alterations detected in acute pancreatitis induced by sodium taurocholate in rats and therapeutic effects of curcumin, ciprofloxacin and metronidazole combination. Pancreatology. 2005;5(4-5):345-353. View abstract.
  1477. Ringman, J. M., Frautschy, S. A., Cole, G. M., Masterman, D. L., and Cummings, J. L. A potential role of the curry spice curcumin in Alzheimer's disease. Curr.Alzheimer Res 2005;2:131-136. View abstract.
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  1482. Okazaki, Y., Iqbal, M., and Okada, S. Suppressive effects of dietary curcumin on the increased activity of renal ornithine decarboxylase in mice treated with a renal carcinogen, ferric nitrilotriacetate. Biochim.Biophys.Acta 6-10-2005;1740:357-366.View abstract.
  1483. Pari, L. and Amali, D. R. Protective role of tetrahydrocurcumin (THC) an active principle of turmeric on chloroquine induced hepatotoxicity in rats. J Pharm Pharm Sci. 2005;8:115-123. View abstract.
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  1485. Kamalakkannan, N., Rukkumani, R., Varma, P. S., Viswanathan, P., Rajasekharan, K. N., and Menon, V. P. Comparative effects of curcumin and an analogue of curcumin in carbon tetrachloride-induced hepatotoxicity in rats. Basic Clin Pharmacol Toxicol 2005;97:15-21. View abstract.
  1486. Ryu, H., Smith, K., Camelo, S. I., Carreras, I., Lee, J., Iglesias, A. H., Dangond, F., Cormier, K. A., Cudkowicz, M. E., Brown, R. H., Jr., and Ferrante, R. J. Sodium phenylbutyrate prolongs survival and regulates expression of anti-apoptotic genes in transgenic amyotrophic lateral sclerosis mice. J Neurochem. 2005;93:1087-1098. View abstract.
  1487. Wessler, S., Muenzner, P., Meyer, T. F., and Naumann, M. The anti-inflammatory compound curcumin inhibits Neisseria gonorrhoeae-induced NF-kappaB signaling, release of pro-inflammatory cytokines/chemokines and attenuates adhesion in late infection. Biol.Chem. 2005;386:481-490. View abstract.
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  1490. Collado, B., Sanchez, M. G., Diaz-Laviada, I., Prieto, J. C., and Carmena, M. J. Vasoactive intestinal peptide (VIP) induces c-fos expression in LNCaP prostate cancer cells through a mechanism that involves Ca2+ signalling. Implications in angiogenesis and neuroendocrine differentiation. Biochim.Biophys.Acta 6-30-2005;1744:224-233. View abstract.
  1491. Suryanarayana, P., Saraswat, M., Mrudula, T., Krishna, T. P., Krishnaswamy, K., and Reddy, G. B. Curcumin and turmeric delay streptozotocin-induced diabetic cataract in rats. Invest Ophthalmol.Vis.Sci. 2005;46:2092-2099. View abstract.
  1492. Daduang, S., Sattayasai, N., Sattayasai, J., Tophrom, P., Thammathaworn, A., Chaveerach, A., and Konkchaiyaphum, M. Screening of plants containing Naja naja siamensis cobra venom inhibitory activity using modified ELISA technique. Anal.Biochem. 6-15-2005;341:316-325. View abstract.
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  1494. Cao, W. G., Morin, M., Metz, C., Maheux, R., and Akoum, A. Stimulation of macrophage migration inhibitory factor expression in endometrial stromal cells by interleukin 1, beta involving the nuclear transcription factor NFkappaB. Biol.Reprod. 2005;73:565-570. View abstract.
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  1501. Padmaja, S. and Raju, T. N. Protective effect of curcumin during selenium induced toxicity on dehydrogenases in hepatic tissue. Indian J Physiol Pharmacol 2005;49:111-114. View abstract.
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  1504. Kwon, Y. K., Jun, J. M., Shin, S. W., Cho, J. W., and Suh, S. I. Curcumin decreases cell proliferation rates through BTG2-mediated cyclin D1 down-regulation in U937 cells. Int.J Oncol. 2005;26:1597-1603. View abstract.
  1505. Hayes, K. C., Pronczuk, A., Wijendran, V., and Beer, M. Free phytosterols facilitate excretion of endogenous cholesterol in gerbils. J Nutr.Biochem. 2005;16:305-311. View abstract.
  1506. Kuroda, M., Mimaki, Y., Nishiyama, T., Mae, T., Kishida, H., Tsukagawa, M., Takahashi, K., Kawada, T., Nakagawa, K., and Kitahara, M. Hypoglycemic effects of turmeric (Curcuma longa L. rhizomes) on genetically diabetic KK-Ay mice. Biol.Pharm Bull. 2005;28:937-939. View abstract.
  1507. Weber, W. M., Hunsaker, L. A., Abcouwer, S. F., Deck, L. M., and Vander Jagt, D. L. Anti-oxidant activities of curcumin and related enones. Bioorg.Med.Chem. 6-1-2005;13:3811-3820. View abstract.
  1508. Wang, W., Li, G., Clancy, J. P., and Kirk, K. L. Activating cystic fibrosis transmembrane conductance regulator channels with pore blocker analogs. J Biol.Chem. 6-24-2005;280:23622-23630. View abstract.
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  1510. Su, S. H., Nguyen, K. T., Satasiya, P., Greilich, P. E., Tang, L., and Eberhart, R. C. Curcumin impregnation improves the mechanical properties and reduces the inflammatory response associated with poly(L-lactic acid) fiber. J Biomater.Sci.Polym.Ed 2005;16:353-370. View abstract.
  1511. Basu, N. K., Kovarova, M., Garza, A., Kubota, S., Saha, T., Mitra, P. S., Banerjee, R., Rivera, J., and Owens, I. S. Phosphorylation of a UDP-glucuronosyltransferase regulates substrate specificity. Proc.Natl.Acad.Sci.U.S A 5-3-2005;102:6285-6290. View abstract.
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